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Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging

  • Authors:
    • Daiki Abe
    • Tsutomu Takeda
    • Daisuke Asaoka
    • Tomoyo Iwano
    • Ryota Uchida
    • Hisanori Utsunomiya
    • Shotaro Oki
    • Nobuyuki Suzuki
    • Atsushi Ikeda
    • Noboru Yatagai
    • Yoichi Akazawa
    • Kohei Matsumoto
    • Kumiko Ueda
    • Hiroya Ueyama
    • Mariko Hojo
    • Yuko Kojima
    • Shinji Nakamura
    • Shuko Nojiri
    • Akihito Nagahara
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Juntendo University School of Medicine, Tokyo 113‑8421, Japan, Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136‑0075, Japan, Laboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University School of Medicine, Tokyo 113‑8421, Japan, Department of Medical Technology Innovation Center, Juntendo University School of Medicine, Tokyo 113‑8421, Japan
    Copyright: © Abe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 83
    |
    Published online on: August 25, 2022
       https://doi.org/10.3892/br.2022.1566
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Abstract

Bile acids are strongly associated with the pathogenesis of functional gastrointestinal diseases. In recent years, blue laser imaging (BLI) endoscopy has emerged as a novel image‑enhanced endoscopic method, which illustrates bile as a reddish hue. The present study investigated the factors that affect the area of bile in duodenal bulbs using BLI. For this purpose, patients (356 cases) who underwent upper endoscopy with BLI between April, 2017 and December, 2019, and completed patient background and symptom questionnaires [Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) and Frequency Scale for Symptoms of gastroesophageal reflux disease (FSSG)], were retrospectively investigated. Each BLI bile score was calculated as a percentage of bile area in a field of view in the duodenal bulb using a KS400 image analysis system, and the association with abdominal symptoms was examined using multiple regression analysis. The patient characteristics included the following: Age (in years), 69.9±11.3; male/female ratio, 146/210; body mass index, 23.0±3.8; reflux esophagitis (M/A/B/C), 143/19/3/3; atrophic gastritis (C‑0/C1‑3/O1‑3), 132/100/124; proton pump inhibitor potassium competitive acid blocker/aspirin/ursodeoxycholic acid/gall bladder stones/cholecystectomy, 105/27/18/43/18; BLI bile score, 7.10 (±14.34); CSS score, 3.55 (±3.80); BSFS score, 3.91 (±1.02); and FSSG score, 4.80 (±5.76). Correlation coefficients (P<0.05) for the BLI bile score were found for cholecystectomy (Rho=0.137) and aspirin use (Rho=0.118). In multiple regression analysis, independent predictors of the BLI bile score were cholecystectomy [standardized partial regression coefficient (β)=0.169, P=0.001] and the BSFS score (β=0.107, P=0.042). On the whole, the present study demonstrates that the duodenal bile area in BLI upper endoscopy is associated with cholecystectomy and fecal characteristics.
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1 

Sperber AD, Bangdiwala SI, Drossman DA, Ghoshal UC, Simren M, Tack J, Whitehead WE, Dumitrascu DL, Fang X, Fukudo S, et al: Worldwide prevalence and burden of functional gastrointestinal disorders, results of rome foundation global study. Gastroenterology. 160:99–114.e3. 2021.PubMed/NCBI View Article : Google Scholar

2 

Higgins PD and Johanson JF: Epidemiology of constipation in North America: A systematic review. Am J Gastroenterol. 99:750–759. 2004.PubMed/NCBI View Article : Google Scholar

3 

Tamura A, Tomita T, Oshima T, Toyoshima F, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ikehara H, et al: Prevalence and self-recognition of chronic constipation: Results of an internet survey. J Neurogastroenterol Motil. 22:677–685. 2016.PubMed/NCBI View Article : Google Scholar

4 

Wald A, Scarpignato C, Kamm MA, Mueller-Lissner S, Helfrich I, Schuijt C, Bubeck J, Limoni C and Petrini O: The burden of constipation on quality of life: Results of a multinational survey. Aliment Pharmacol Ther. 26:227–236. 2007.PubMed/NCBI View Article : Google Scholar

5 

Tanabe A, Adachi K, Yamaguchi Y, Izawa S, Yamamoto S, Hijikata Y, Ebi M, Funaki Y, Ogasawara N, Goto C, et al: Gut environment and dietary habits in healthy Japanese adults and their association with bowel movement. Digestion. 101:706–716. 2020.PubMed/NCBI View Article : Google Scholar

6 

Canavan C, West J and Card T: Review article: The economic impact of the irritable bowel syndrome. Aliment Pharmacol Ther. 40:1023–1034. 2014.PubMed/NCBI View Article : Google Scholar

7 

Appleby RN and Walters JR: The role of bile acids in functional GI disorders. Neurogastroenterol Motil. 26:1057–1069. 2014.PubMed/NCBI View Article : Google Scholar

8 

Nakajima A, Seki M and Taniguchi S: Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: A phase II, multicenter, double-blind, placebo-controlled randomized clinical trial. J Gastroenterol. 53:525–534. 2018.PubMed/NCBI View Article : Google Scholar

9 

Nakajima A, Seki M, Taniguchi S, Ohta A, Gillberg PG, Mattsson JP and Camilleri M: Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase-3 trial and an open-label, single-arm, phase 3 trial. Lancet Gastroenterol Hepatol. 3:537–547. 2018.PubMed/NCBI View Article : Google Scholar

10 

Beeckmans D, Farré R, Riethorst D, Keita ÅV, Augustijns P, Söderholm JD, Vanuytsel T, Vanheel H and Tack J: Relationship between bile salts, bacterial translocation, and duodenal mucosal integrity in functional dyspepsia. Neurogastroenterol Motil. 32(e13788)2022.PubMed/NCBI View Article : Google Scholar

11 

Wauters L, Ceulemans M, Lambaerts M, Accarie A, Toth J, Mols R, Augustijns P, Tack J and Vanuytsel T: Association between duodenal bile salts and gastric emptying in patients with functional dyspepsia. Gut. 70:2208–2210. 2021.PubMed/NCBI View Article : Google Scholar

12 

Choi HJ, Moon JH and Lee YN: . Advanced imaging technology in biliary tract diseases:Narrow-band imaging of the bile duct. Clin Endosc. 48:498–502. 2015.PubMed/NCBI View Article : Google Scholar

13 

Moon JH, Terheggen G, Choi HJ and Neuhaus H: Peroral cholangioscopy: Diagnostic and therapeutic applications. Gastroenterology. 144:276–282. 2013.PubMed/NCBI View Article : Google Scholar

14 

Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Ishii K, Tsuji S, Moriyasu F and Gotoda T: Peroral cholangioscopic diagnosis of biliary-tract diseases by using narrow-band imaging (with videos). Gastrointest Endosc. 66:730–736. 2007.PubMed/NCBI View Article : Google Scholar

15 

Armstrong D, Bennett JR, Blum AL, Dent J, De Dombal FT, Galmiche JP, Lundell L, Margulies M, Richter JE, Spechler SJ, et al: The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology. 111:85–92. 1996.PubMed/NCBI View Article : Google Scholar

16 

Hongo M: Minimal changes in reflux esophagitis: Red ones and white ones. J Gastroenterol. 41:95–99. 2006.PubMed/NCBI View Article : Google Scholar

17 

Sharma P, Dent J, Armstrong D, Bergman JJ, Gossner L, Hoshihara Y, Jankowski JA, Junghard O, Lundell L, Tytgat GN and Vieth M: The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria. Gastroenterology. 131:1392–1399. 2006.PubMed/NCBI View Article : Google Scholar

18 

Kimura K and Takemoto T: An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 1:87–97. 1969.

19 

Agachan F, Chen T, Pfeifer J, Reissman P and Wexner SD: A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 39:681–685. 1996.PubMed/NCBI View Article : Google Scholar

20 

Lewis SJ and Heaton KW: Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 32:920–924. 1997.PubMed/NCBI View Article : Google Scholar

21 

Chiang JY: Bile acid metabolism and signaling. Compr Physiol. 3:1191–1212. 2013.PubMed/NCBI View Article : Google Scholar

22 

Chiang JYL and Ferrell JM: Bile acid metabolism in liver pathobiology. Gene Expr. 18:71–87. 2018.PubMed/NCBI View Article : Google Scholar

23 

Di Ciaula A, Garruti G, Lunardi Baccetto R, Molina-Molina E, Bonfrate L, Wang DQ and Portincasa P: Bile acid physiology. Ann Hepatol. 16 (Suppl 1: S3-S105):S4–S14. 2017.PubMed/NCBI View Article : Google Scholar

24 

Bampton PA, Dinning PG, Kennedy ML, Lubowski DZ and Cook IJ: The proximal colonic motor response to rectal mechanical and chemical stimulation. Am J Physiol Gastrointest Liver Physiol. 282:G443–G449. 2002.PubMed/NCBI View Article : Google Scholar

25 

Hofmann AF: The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 159:2647–2658. 1999.PubMed/NCBI View Article : Google Scholar

26 

Edwards CA, Brown S, Baxter AJ, Bannister JJ and Read NW: Effect of bile acid on anorectal function in man. Gut. 30:383–386. 1989.PubMed/NCBI View Article : Google Scholar

27 

Shin A, Camilleri M, Vijayvargiya P, Busciglio I, Burton D, Ryks M, Rhoten D, Lueke A, Saenger A, Girtman A and Zinsmeister AR: Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 11:1270–1275.e1. 2013.PubMed/NCBI View Article : Google Scholar

28 

Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D, Carlson P, Lamsam J, Singh R and Zinsmeister AR: Gastroenterology. 139:1549–1558. 2010.

29 

Camilleri M: Bile acid diarrhea: Prevalence, pathogenesis, and therapy. Gut Liver. 9:332–339. 2015.PubMed/NCBI View Article : Google Scholar

30 

Yueh TP, Chen FY, Lin TE and Chuang MT: Diarrhea after laparoscopic cholecystectomy: Associated factors and predictors. Asian J Surg. 37:171–177. 2014.PubMed/NCBI View Article : Google Scholar

31 

Hutcheon DF, Bayless TM and Gadacz TR: Postcholecystectomy diarrhea. JAMA. 241:823–824. 1979.PubMed/NCBI

32 

Fisher M, Spilias DC and Tong LK: Diarrhoea after laparoscopic cholecystectomy: Incidence and main determinants. ANZ J Surg. 78:482–486. 2008.PubMed/NCBI View Article : Google Scholar

33 

Middelfart HV, Kristensen JU, Laursen CN, Qvist N, Højgaard L, Funch-Jensen P and Kehlet H: Pain and dyspepsia after elective and acute cholecystectomy. Scand J Gastroenterol. 33:10–14. 1998.PubMed/NCBI View Article : Google Scholar

34 

Lublin M, Crawford DL, Hiatt JR and Phillips EH: Symptoms before and after laparoscopic cholecystectomy for gallstones. Am Surg. 70:863–866. 2004.PubMed/NCBI

35 

Weinert CR, Arnett D, Jacobs D Jr and Kane RL: Relationship between persistence of abdominal symptoms and successful outcome after cholecystectomy. Arch Intern Med. 160:989–995. 2000.PubMed/NCBI View Article : Google Scholar

36 

Niranjan B, Chumber S and Kriplani AK: Symptomatic outcome after laparoscopic cholecystectomy. Trop Gastroenterol. 21:144–148. 2000.PubMed/NCBI

37 

Lamberts MP, Lugtenberg M, Rovers MM, Roukema AJ, Drenth JP, Westert GP and van Laarhoven CJ: Persistent and de novo symptoms after cholecystectomy: A systematic review of cholecystectomy effectiveness. Surg Endosc. 27:709–718. 2013.PubMed/NCBI View Article : Google Scholar

38 

Sciarretta G, Furno A, Mazzoni M and Malaguti P: Post-cholecystectomy diarrhea: evidence of bile acid malabsorption assessed by SeHCAT test. Am J Gastroenterol. 87:1852–1854. 1992.PubMed/NCBI

39 

Mearin F, De Ribot X, Balboa A, Antolín M, Varas MJ and Malagelada JR: Duodenogastric bile reflux and gastrointestinal motility in pathogenesis of functional dyspepsia. Role of cholecystectomy. Dig Dis Sci. 40:1703–1709. 1995.PubMed/NCBI View Article : Google Scholar

40 

Monaco L, Brillantino A, Torelli F, Schettino M, Izzo G, Cosenza A and Di Martino N: Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors. World J Gastroenterol. 15:334–338. 2009.PubMed/NCBI View Article : Google Scholar

41 

Bollschweiler E, Wolfgarten E, Pütz B, Gutschow C and Hölscher AH: Bile reflux into the stomach and the esophagus for volunteers older than 40 years. Digestion. 71:65–71. 2005.PubMed/NCBI View Article : Google Scholar

42 

McCabe ME IV and Dilly CK: New causes for the old problem of bile reflux gastritis. Clin Gastroenterol Hepatol. 16:1389–1392. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Abe D, Takeda T, Asaoka D, Iwano T, Uchida R, Utsunomiya H, Oki S, Suzuki N, Ikeda A, Yatagai N, Yatagai N, et al: Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging. Biomed Rep 17: 83, 2022.
APA
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H. ... Nagahara, A. (2022). Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging. Biomedical Reports, 17, 83. https://doi.org/10.3892/br.2022.1566
MLA
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H., Oki, S., Suzuki, N., Ikeda, A., Yatagai, N., Akazawa, Y., Matsumoto, K., Ueda, K., Ueyama, H., Hojo, M., Kojima, Y., Nakamura, S., Nojiri, S., Nagahara, A."Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging". Biomedical Reports 17.4 (2022): 83.
Chicago
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H., Oki, S., Suzuki, N., Ikeda, A., Yatagai, N., Akazawa, Y., Matsumoto, K., Ueda, K., Ueyama, H., Hojo, M., Kojima, Y., Nakamura, S., Nojiri, S., Nagahara, A."Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging". Biomedical Reports 17, no. 4 (2022): 83. https://doi.org/10.3892/br.2022.1566
Copy and paste a formatted citation
x
Spandidos Publications style
Abe D, Takeda T, Asaoka D, Iwano T, Uchida R, Utsunomiya H, Oki S, Suzuki N, Ikeda A, Yatagai N, Yatagai N, et al: Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging. Biomed Rep 17: 83, 2022.
APA
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H. ... Nagahara, A. (2022). Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging. Biomedical Reports, 17, 83. https://doi.org/10.3892/br.2022.1566
MLA
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H., Oki, S., Suzuki, N., Ikeda, A., Yatagai, N., Akazawa, Y., Matsumoto, K., Ueda, K., Ueyama, H., Hojo, M., Kojima, Y., Nakamura, S., Nojiri, S., Nagahara, A."Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging". Biomedical Reports 17.4 (2022): 83.
Chicago
Abe, D., Takeda, T., Asaoka, D., Iwano, T., Uchida, R., Utsunomiya, H., Oki, S., Suzuki, N., Ikeda, A., Yatagai, N., Akazawa, Y., Matsumoto, K., Ueda, K., Ueyama, H., Hojo, M., Kojima, Y., Nakamura, S., Nojiri, S., Nagahara, A."Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging". Biomedical Reports 17, no. 4 (2022): 83. https://doi.org/10.3892/br.2022.1566
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