Relationship between protein arginine methyltransferase and cardiovascular disease (Review)

  • Authors:
    • Sisi Zheng
    • Congcong Zeng
    • Ailing Huang
    • Fuqi Huang
    • Anna Meng
    • Zhuan Wu
    • Shouhong Zhou
  • View Affiliations

  • Published online on: September 16, 2022     https://doi.org/10.3892/br.2022.1572
  • Article Number: 90
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Abstract

Protein arginine methyltransferases (PRMTs) are widely found in eukaryotes and regulate gene expression and post‑translational modifications. PRMT1‑PRMT6 have important roles in the pathology of cardiovascular diseases (CVDs), including atherosclerosis, heart failure and myocardial hypertrophy. Although these enzymes are also closely associated with various CVDs, the mechanisms of the involvement of PRMTs in the regulation of CVD have remained largely elusive. PRMTs methylate arginine residues and other factors. The present review describes the roles of PRMT1‑PRMT6 in CVD. Furthermore, the biological characteristics of PRMTs and mechanisms by which PRMTs regulate cholesterol metabolism are being introduced. This review aims to provide inspiration for cardiovascular drug research and offer clues for research on the pathogenesis of CVD.
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November-2022
Volume 17 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng S, Zeng C, Huang A, Huang F, Meng A, Wu Z and Zhou S: Relationship between protein arginine methyltransferase and cardiovascular disease (Review). Biomed Rep 17: 90, 2022
APA
Zheng, S., Zeng, C., Huang, A., Huang, F., Meng, A., Wu, Z., & Zhou, S. (2022). Relationship between protein arginine methyltransferase and cardiovascular disease (Review). Biomedical Reports, 17, 90. https://doi.org/10.3892/br.2022.1572
MLA
Zheng, S., Zeng, C., Huang, A., Huang, F., Meng, A., Wu, Z., Zhou, S."Relationship between protein arginine methyltransferase and cardiovascular disease (Review)". Biomedical Reports 17.5 (2022): 90.
Chicago
Zheng, S., Zeng, C., Huang, A., Huang, F., Meng, A., Wu, Z., Zhou, S."Relationship between protein arginine methyltransferase and cardiovascular disease (Review)". Biomedical Reports 17, no. 5 (2022): 90. https://doi.org/10.3892/br.2022.1572