Open Access

CRP as a potential predictor of outcome in acute ischemic stroke

  • Authors:
    • Jing Bian
    • Siping Guo
    • Tingting Huang
    • Xiuyun Li
    • Shoucai Zhao
    • Zhaohu Chu
    • Zibao Li
  • View Affiliations

  • Published online on: January 17, 2023     https://doi.org/10.3892/br.2023.1599
  • Article Number: 17
  • Copyright: © Bian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ischemic stroke is one of the major causes of death and long‑term disability worldwide. C‑reactive protein (CRP) as a potential biomarker for functional outcome after acute ischemic stroke remains controversial. The aim of the present study was to examine the association between the level of CRP and functional outcome of stroke. A total of 218 consecutive patients with acute ischemic stroke within 24 h after onset were recruited for the study. Poor functional outcome was defined as a modified Rankin scale score of >2 at 3 months after stroke. The retrospective analysis was performed to investigate whether CRP within 24 h after stroke is associated with poor functional outcome at 3 months. Multivariate logistic regression analysis indicated that the CRP level (odds ratio=1.146, 95%CI: 1.012‑1.297, P=0.031) was an independent risk factor for poor outcome. The receiver operating characteristics curve analysis revealed that the optimal cut‑off value of CRP to distinguish favorable from poor outcome was 6.34 (area under the curve=0.829, 95%CI: 0.772‑0.887, P<0.001), with 68.2% sensitivity and 85.7% specificity. Spearman correlation analysis indicated that the CRP level was positively related to the baseline National Institutes of Health Stroke Scale (NIHSS) score (r=0.551, P<0.001), fasting glucose (r=0.301, P<0.001) and age (r=0.252, P<0.001). In conclusion, a high level of CRP within 24 h after onset was associated with a poor functional outcome after the acute ischemic event. The elevation of CRP may be correlated with the baseline NIHSS score, fasting glucose and age.
View Figures
View References

Related Articles

Journal Cover

February-2023
Volume 18 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bian J, Guo S, Huang T, Li X, Zhao S, Chu Z and Li Z: CRP as a potential predictor of outcome in acute ischemic stroke. Biomed Rep 18: 17, 2023
APA
Bian, J., Guo, S., Huang, T., Li, X., Zhao, S., Chu, Z., & Li, Z. (2023). CRP as a potential predictor of outcome in acute ischemic stroke. Biomedical Reports, 18, 17. https://doi.org/10.3892/br.2023.1599
MLA
Bian, J., Guo, S., Huang, T., Li, X., Zhao, S., Chu, Z., Li, Z."CRP as a potential predictor of outcome in acute ischemic stroke". Biomedical Reports 18.2 (2023): 17.
Chicago
Bian, J., Guo, S., Huang, T., Li, X., Zhao, S., Chu, Z., Li, Z."CRP as a potential predictor of outcome in acute ischemic stroke". Biomedical Reports 18, no. 2 (2023): 17. https://doi.org/10.3892/br.2023.1599