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Parkinson's disease and cardiovascular involvement: Edifying insights (Review)

  • Authors:
    • Laura Grosu
    • Alin Ionut Grosu
    • Dana Crisan
    • Alexandru Zlibut
    • Lacramioara Perju-Dumbrava
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, Department of Internal Medicine, 5th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, 400139 Cluj-Napoca, Romania
    Copyright: © Grosu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
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    Published online on: February 14, 2023
       https://doi.org/10.3892/br.2023.1607
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Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative illnesses, and is a major healthcare burden with prodigious consequences on life‑quality, morbidity, and survival. Cardiovascular diseases are the leading cause of mortality worldwide and growing evidence frequently reports their co‑existence with PD. Cardiac dysautonomia due to autonomic nervous system malfunction is the most prevalent type of cardiovascular manifestation in these patients, comprising orthostatic and postprandial hypotension, along with supine and postural hypertension. Moreover, many studies have endorsed the risk of patients with PD to develop ischemic heart disease, heart failure and even arrhythmias, but the underlying mechanisms are not entirely clear. As importantly, the medication used in treating PD, such as levodopa, dopamine agonists or anticholinergic agents, is also responsible for cardiovascular adverse reactions, but further studies are required to elucidate the underlying mechanisms. The purpose of this review was to provide a comprehensive overview of current available data regarding the overlapping cardiovascular disease in patients with PD.
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Copy and paste a formatted citation
Spandidos Publications style
Grosu L, Grosu AI, Crisan D, Zlibut A and Perju-Dumbrava L: Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomed Rep 18: 25, 2023.
APA
Grosu, L., Grosu, A.I., Crisan, D., Zlibut, A., & Perju-Dumbrava, L. (2023). Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomedical Reports, 18, 25. https://doi.org/10.3892/br.2023.1607
MLA
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18.3 (2023): 25.
Chicago
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18, no. 3 (2023): 25. https://doi.org/10.3892/br.2023.1607
Copy and paste a formatted citation
x
Spandidos Publications style
Grosu L, Grosu AI, Crisan D, Zlibut A and Perju-Dumbrava L: Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomed Rep 18: 25, 2023.
APA
Grosu, L., Grosu, A.I., Crisan, D., Zlibut, A., & Perju-Dumbrava, L. (2023). Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomedical Reports, 18, 25. https://doi.org/10.3892/br.2023.1607
MLA
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18.3 (2023): 25.
Chicago
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18, no. 3 (2023): 25. https://doi.org/10.3892/br.2023.1607
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