Open Access

Parkinson's disease and cardiovascular involvement: Edifying insights (Review)

  • Authors:
    • Laura Grosu
    • Alin Ionut Grosu
    • Dana Crisan
    • Alexandru Zlibut
    • Lacramioara Perju-Dumbrava
  • View Affiliations

  • Published online on: February 14, 2023     https://doi.org/10.3892/br.2023.1607
  • Article Number: 25
  • Copyright: © Grosu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative illnesses, and is a major healthcare burden with prodigious consequences on life‑quality, morbidity, and survival. Cardiovascular diseases are the leading cause of mortality worldwide and growing evidence frequently reports their co‑existence with PD. Cardiac dysautonomia due to autonomic nervous system malfunction is the most prevalent type of cardiovascular manifestation in these patients, comprising orthostatic and postprandial hypotension, along with supine and postural hypertension. Moreover, many studies have endorsed the risk of patients with PD to develop ischemic heart disease, heart failure and even arrhythmias, but the underlying mechanisms are not entirely clear. As importantly, the medication used in treating PD, such as levodopa, dopamine agonists or anticholinergic agents, is also responsible for cardiovascular adverse reactions, but further studies are required to elucidate the underlying mechanisms. The purpose of this review was to provide a comprehensive overview of current available data regarding the overlapping cardiovascular disease in patients with PD.
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March-2023
Volume 18 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Grosu L, Grosu AI, Crisan D, Zlibut A and Perju-Dumbrava L: Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomed Rep 18: 25, 2023
APA
Grosu, L., Grosu, A.I., Crisan, D., Zlibut, A., & Perju-Dumbrava, L. (2023). Parkinson's disease and cardiovascular involvement: Edifying insights (Review). Biomedical Reports, 18, 25. https://doi.org/10.3892/br.2023.1607
MLA
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18.3 (2023): 25.
Chicago
Grosu, L., Grosu, A. I., Crisan, D., Zlibut, A., Perju-Dumbrava, L."Parkinson's disease and cardiovascular involvement: Edifying insights (Review)". Biomedical Reports 18, no. 3 (2023): 25. https://doi.org/10.3892/br.2023.1607