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Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke

  • Authors:
    • Enzhuo Chen
    • Dong Zhou
    • Ruoyu Deng
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China, Department of Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P.R. China, Health Management, University of Montpellier, Montpellier 34090, France
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: November 23, 2023
       https://doi.org/10.3892/br.2023.1698
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Abstract

Resolvin D1 (RvD1) represses inflammation, oxidative damage and neural injury related to acute ischemic stroke (AIS) progression. The present study aimed to explore the association of serum RvD1 with disease features, neurological recovery and prognosis in patients with AIS. A total of 212 patients with newly diagnosed AIS, whose serum RvD1 was quantified at admission and at discharge using an ELISA were enrolled in the current study. The modified Rankin scale (mRS) score was noted at 3 months after patient enrolment (M3), and patients were followed up for a median duration of 11.4 (range, 1.1‑21.0) months. The median RvD1 in patients with AIS at admission was 1.07 (range, 0.11‑9.29) ng/ml and it was negatively correlated with the neutrophil/lymphocyte ratio (r=‑0.160; P=0.009) and C‑reactive protein level (r=‑0.272; P<0.001), but it was not correlated with comorbidities or other biochemical indexes. RvD1 at admission was lower in patients with mRS >2 at M3 (P=0.001), recurrence (P=0.001) or death (P=0.032) compared with that in patients without the aforementioned characteristics, which had a general ability to estimate mRS >2 at M3 [area under curve (AUC), 0.633], as well as lower risk of recurrence (AUC, 0.745) and death (AUC, 0.757) according to receiver operator characteristic (ROC) curve analyses. The median RvD1 was raised to 1.70 (range, 0.30‑16.62) ng/ml at discharge. RvD1 at discharge was able to forecast mRS >2 at M3 (AUC, 0.678) and was able to predict the risk of recurrence (AUC, 0.796) and death (AUC, 0.826) in the ROC curve analyses. Increased serum RvD1 was associated with an attenuated inflammation status, and predicted improved neurological recovery, and lower risk of recurrence and death in patients with AIS. More specifically, its level at discharge exhibits a better prognostic utility than that at admission.
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1 

Bathla G, Ajmera P, Mehta PM, Benson JC, Derdeyn CP, Lanzino G, Agarwal A and Brinjikji W: Advances in acute ischemic stroke treatment: Current status and future directions. AJNR Am J Neuroradiol. 44:750–758. 2023.PubMed/NCBI View Article : Google Scholar

2 

Tu WJ, Zhao Z, Yin P, Cao L, Zeng J, Chen H, Fan D, Fang Q, Gao P, Gu Y, et al: Estimated Burden of stroke in China in 2020. JAMA Netw Open. 6(e231455)2023.PubMed/NCBI View Article : Google Scholar

3 

Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, et al: Stroke in China: Advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 18:394–405. 2019.PubMed/NCBI View Article : Google Scholar

4 

Posul E, Yilmaz B, Aktas G and Kurt M: Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis? Wien Klin Wochenschr. 127:262–265. 2015.PubMed/NCBI View Article : Google Scholar

5 

Duman TT, Aktas G, Atak BM, Kocak MZ, Erkus E and Savli H: Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus. Afr Health Sci. 19:1602–1606. 2019.PubMed/NCBI View Article : Google Scholar

6 

Sahin S, Sarikaya S, Alcelik A, Erdem A and Karaman KJAMM: Neutrophil to lymphocyte ratio is a useful predictor of atrial fibrillation in patients with diabetes mellitus. Acta Medica Mediterranea. 29:847–851. 2013.

7 

Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E and Savli H: Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis. Rev Assoc Med Bras (1992). 63:1065–1068. 2017.PubMed/NCBI View Article : Google Scholar

8 

Khalid A, Ali Jaffar M, Khan T, Abbas Lail R, Ali S, Aktas G, Waris A, Javaid A, Ijaz N and Muhammad N: Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: A retrospective comparative analysis. Hematology. 26:529–542. 2021.PubMed/NCBI View Article : Google Scholar

9 

Bilgin S, Kurtkulagi O, Atak BM, Duman TT, Kahveci G, Khalid A and Aktas G: Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? The CARE TIME study. Prim Care Diabetes. 15:1071–1074. 2021.PubMed/NCBI View Article : Google Scholar

10 

Demirkol ME and Aktas G: C-reactive protein to LymphocytE count ratio could be a reliable mArkeR of thyroiditis; the CLEAR-T study. Precision Med Sci. 11:31–34. 2022.

11 

Mojahedi MJ, Bonakdaran S, Hami M, Sheikhian MR, Shakeri MT and Aiatollahi H: Elevated serum C-reactive protein level and microalbuminuria in patients with type 2 diabetes mellitus. Iran J Kidney Dis. 3:12–6. 2009.PubMed/NCBI

12 

Demirkol ME, Aktas G, Bilgin S, Kahveci G, Kurtkulagi O, Atak BM and Duman TT: C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: The clear hep-c study. Rev Assoc Med Bras (1992). 68:838–841. 2022.PubMed/NCBI View Article : Google Scholar

13 

Demirkol ME, Bilgin S, Kahveci G, Kurtkulagi O, Atak BM, Duman TT and Aktas G: C-reactive protein-to-lymphocyte ratio is a reliable marker in patients with COVID-19 infection: The CLEAR COVID study. Cir Cir. 90:596–601. 2022.PubMed/NCBI View Article : Google Scholar

14 

Afsin H and Aktas G: Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios are useful in differentiation of thyroid conditions with normal and increased uptake. Ethiop J Health Dev. 35:149–153. 2021.

15 

Erge E, Kiziltunc C, Balci SB, Atak BM, Bilgin S, Duman TT and Aktas G: A novel inflammatory marker for the diagnosis of hashimoto&rsquo;s thyroiditis: Platelet-count-to-lymphocyte-count ratio. Diseases. 11(15)2023.PubMed/NCBI View Article : Google Scholar

16 

Atak BM, Kahveci G, Bilgin S, Kurtkulagi O and Kosekli MA: Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules. Exp Biomed Res. 4:148–153. 2021.PubMed/NCBI View Article : Google Scholar

17 

Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ and Savli H: Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Rev Assoc Med Bras (1992). 5:38–42. 2019.PubMed/NCBI View Article : Google Scholar

18 

Aktas G, Duman TT, Atak BM, Kurtkulagi O, Bilgin S, Basaran E, Demirkol ME and Kosekli MA: Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters. Fam Med Prim Care Rev. 22:107–110. 2020.

19 

Aktas G: Hematological predictors of novel Coronavirus infection. Rev Assoc Med Bras (1992). 67 (Suppl 1):S1–S2. 2021.PubMed/NCBI View Article : Google Scholar

20 

Liu YL, Wu ZQ, Qu JF, Qiu DH, Luo GP, Yin HP, Fang XW, Wang F and Chen YK: High neutrophil-to-lymphocyte ratio is a predictor of poor short-term outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis. Brain Behav. 10(e01857)2020.PubMed/NCBI View Article : Google Scholar

21 

Yang Y, Xie D and Zhang Y: Increased Platelet-to-Lymphocyte Ratio is an Independent Predictor of Hemorrhagic Transformation and In-Hospital Mortality among acute ischemic stroke with large-artery atherosclerosis patients. Int J Gen Med. 14:7545–7555. 2021.PubMed/NCBI View Article : Google Scholar

22 

Wang H, Zhang S, Xie L, Zhong Z and Yan F: Neuroinflammation and peripheral immunity: Focus on ischemic stroke. Int Immunopharmacol. 120(110332)2023.PubMed/NCBI View Article : Google Scholar

23 

Cheng Y, Zhang W, Cao W, Shao M, Lin Y, Shao B, Yu H and Deng B: 2-BFI attenuates ischemic injury by modulating mTOR signaling and neuroinflammation in rats. Neurosci Lett. 750(135766)2021.PubMed/NCBI View Article : Google Scholar

24 

Zhu H, Zhang Y, Zhong Y, Ye Y, Hu X, Gu L and Xiong X: Inflammation-mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 15(652647)2021.PubMed/NCBI View Article : Google Scholar

25 

Charabati M, Zandee S, Fournier AP, Tastet O, Thai K, Zaminpeyma R, Lecuyer MA, Bourbonniere L, Larouche S, Klement W, et al: MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes. Brain. 146:1483–1495. 2023.PubMed/NCBI View Article : Google Scholar

26 

Weiner HL and Selkoe DJ: Inflammation and therapeutic vaccination in CNS diseases. Nature. 420:879–884. 2002.PubMed/NCBI View Article : Google Scholar

27 

von Schacky C: Importance of EPA and DHA Blood Levels in Brain Structure and Function. Nutrients. 13(1074)2021.PubMed/NCBI View Article : Google Scholar

28 

Sun GY, Simonyi A, Fritsche KL, Chuang DY, Hannink M, Gu Z, Greenlief CM, Yao JK, Lee JC and Beversdorf DQ: Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases. Prostaglandins Leukot Essent Fatty Acids. 136:3–13. 2018.PubMed/NCBI View Article : Google Scholar

29 

Tulowiecka N, Kotlega D, Prowans P and Szczuko M: The role of resolvins: EPA and DHA derivatives can be useful in the prevention and treatment of ischemic stroke. Int J Mol Sci. 21(7628)2020.PubMed/NCBI View Article : Google Scholar

30 

Liu G, Fiala M, Mizwicki MT, Sayre J, Magpantay L, Siani A, Mahanian M, Chattopadhyay M, La Cava A and Wiedau-Pazos M: Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: Inhibition of inflammation by resolvin D1. Am J Neurodegener Dis. 1:60–74. 2012.PubMed/NCBI

31 

Liu GJ, Tao T, Wang H, Zhou Y, Gao X, Gao YY, Hang CH and Li W: Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury. J Neuroinflammation. 17(239)2020.PubMed/NCBI View Article : Google Scholar

32 

Li L, Cheng SQ, Sun YQ, Yu JB, Huang XX, Dong YF, Ji J, Zhang XY, Hu G and Sun XL: Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke. Cell Rep. 42(112617)2023.PubMed/NCBI View Article : Google Scholar

33 

Arnardottir H, Thul S, Pawelzik SC, Karadimou G, Artiach G, Gallina AL, Mysdotter V, Carracedo M, Tarnawski L, Caravaca AS, et al: The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection. J Clin Invest. 131(e142883)2021.PubMed/NCBI View Article : Google Scholar

34 

Mena HA and Spite M: Proresolving receptor tames inflammation in atherosclerosis. J Clin Invest. 131(e155240)2021.PubMed/NCBI View Article : Google Scholar

35 

Hao J, Feng Y, Xu X, Li L, Yang K, Dai G, Gao W, Zhang M, Fan Y, Yin T, et al: Plasma lipid mediators associate with clinical outcome after successful endovascular thrombectomy in patients with acute ischemic stroke. Front Immunol. 13(917974)2022.PubMed/NCBI View Article : Google Scholar

36 

Kotlega D, Peda B, Drozd A, Zembron-Lacny A, Stachowska E, Gramacki J and Szczuko M: Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment. Prostaglandins Other Lipid Mediat. 156(106576)2021.PubMed/NCBI View Article : Google Scholar

37 

Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, et al: Guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 44:870–947. 2013.PubMed/NCBI View Article : Google Scholar

38 

Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, et al: Measurements of acute cerebral infarction: A clinical examination scale. Stroke. 20:864–870. 1989.PubMed/NCBI View Article : Google Scholar

39 

van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ and van Gijn J: Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 19:604–607. 1988.PubMed/NCBI View Article : Google Scholar

40 

Suzuki K, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, Kamiya Y, Shigeta K, Okubo S, Hayakawa M, et al: Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: The SKIP Randomized clinical trial. JAMA. 325:244–253. 2021.PubMed/NCBI View Article : Google Scholar

41 

Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M and Halade GV: Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. J Mol Cell Cardiol. 84:24–35. 2015.PubMed/NCBI View Article : Google Scholar

42 

Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, et al: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. Nat Commun. 10(3945)2019.PubMed/NCBI View Article : Google Scholar

43 

Salas-Hernandez A, Espinoza-Perez C, Vivar R, Espitia-Corredor J, Lillo J, Parra-Flores P, Sanchez-Ferrer CF, Peiro C and Diaz-Araya G: Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro. Mol Biol Rep. 48:57–66. 2021.PubMed/NCBI View Article : Google Scholar

44 

Wei C, Guo S, Liu W, Jin F, Wei B, Fan H, Su H, Liu J, Zhang N, Fang D, et al: Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome. Front Pharmacol. 11(610734)2020.PubMed/NCBI View Article : Google Scholar

45 

Gemperle C, Tran S, Schmid M, Rimann N, Marti-Jaun J, Hartling I, Wawrzyniak P and Hersberger M: Resolvin D1 reduces inflammation in co-cultures of primary human macrophages and adipocytes by triggering macrophages. Prostaglandins Leukot Essent Fatty Acids. 174(102363)2021.PubMed/NCBI View Article : Google Scholar

46 

Titos E, Rius B, Gonzalez-Periz A, Lopez-Vicario C, Moran-Salvador E, Martinez-Clemente M, Arroyo V and Claria J: Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. J Immunol. 187:5408–5418. 2011.PubMed/NCBI View Article : Google Scholar

47 

Stuckey SM, Ong LK, Collins-Praino LE and Turner RJ: Neuroinflammation as a key driver of secondary neurodegeneration following stroke? Int J Mol Sci. 22(13101)2021.PubMed/NCBI View Article : Google Scholar

48 

Roohbakhsh A, Etemad L and Karimi G: Resolvin D1: A key endogenous inhibitor of neuroinflammation. Biofactors. 48:1005–1026. 2022.PubMed/NCBI View Article : Google Scholar

49 

Bisicchia E, Sasso V, Catanzaro G, Leuti A, Besharat ZM, Chiacchiarini M, Molinari M, Ferretti E, Viscomi MT and Chiurchiu V: Resolvin D1 Halts Remote neuroinflammation and improves functional recovery after focal brain damage Via ALX/FPR2 Receptor-Regulated MicroRNAs. Mol Neurobiol. 55:6894–6905. 2018.PubMed/NCBI View Article : Google Scholar

50 

Ren YZ, Zhang BZ, Zhao XJ and Zhang ZY: Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria. J Neurochem. 154:530–546. 2020.PubMed/NCBI View Article : Google Scholar

51 

Jurcau A and Simion A: Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: From pathophysiology to therapeutic strategies. Int J Mol Sci. 23(14)2021.PubMed/NCBI View Article : Google Scholar

52 

Chen PY, Chen GC, Hsiao CL, Hsu PJ, Yang FY, Liu CY, Tsou A, Chang WL, Liu HH and Lin SK: Comparison of clinical features, immune-inflammatory markers, and outcomes between patients with acute in-hospital and out-of-hospital ischemic stroke. J Inflamm Res. 15:881–895. 2022.PubMed/NCBI View Article : Google Scholar

53 

DeLong JH, Ohashi SN, O'Connor KC and Sansing LH: Inflammatory responses after ischemic stroke. Semin Immunopathol. 44:625–648. 2022.PubMed/NCBI View Article : Google Scholar

54 

Recchiuti A: Resolvin D1 and its GPCRs in resolution circuits of inflammation. Prostaglandins Other Lipid Mediat. 107:64–76. 2013.PubMed/NCBI View Article : Google Scholar

55 

Phipps MS and Cronin CA: Management of acute ischemic stroke. BMJ. 368(l6983)2020.PubMed/NCBI View Article : Google Scholar

56 

Karayigit O, Nurkoc SG, Basyigit F and Kiziltunc E: The role of serum resolvin D1 levels in determining the presence and prognosis of ST-Segment elevation myocardial infarction. Med Princ Pract. 31:548–554. 2022.PubMed/NCBI View Article : Google Scholar

57 

Li W, Shan H, Ma Y, Lv X and Zhu S: Prognostic significance of serum resolvin D1 levels in patients with acute supratentorial intracerebral hemorrhage: A prospective longitudinal cohort study. Clin Chim Acta. 547(117446)2023.PubMed/NCBI View Article : Google Scholar

58 

Bazan HA, Lu Y, Jun B, Fang Z, Woods TC and Hong S: Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease. Prostaglandins Leukot Essent Fatty Acids. 125:43–47. 2017.PubMed/NCBI View Article : Google Scholar

59 

Fehlberg CR and Lee JK: Fibrosis in the central nervous system: From the meninges to the vasculature. Cell Tissue Res. 387:351–360. 2022.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Chen E, Zhou D and Deng R: Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomed Rep 20: 10, 2024.
APA
Chen, E., Zhou, D., & Deng, R. (2024). Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomedical Reports, 20, 10. https://doi.org/10.3892/br.2023.1698
MLA
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20.1 (2024): 10.
Chicago
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20, no. 1 (2024): 10. https://doi.org/10.3892/br.2023.1698
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Spandidos Publications style
Chen E, Zhou D and Deng R: Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomed Rep 20: 10, 2024.
APA
Chen, E., Zhou, D., & Deng, R. (2024). Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomedical Reports, 20, 10. https://doi.org/10.3892/br.2023.1698
MLA
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20.1 (2024): 10.
Chicago
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20, no. 1 (2024): 10. https://doi.org/10.3892/br.2023.1698
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