Open Access

Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke

  • Authors:
    • Enzhuo Chen
    • Dong Zhou
    • Ruoyu Deng
  • View Affiliations

  • Published online on: November 23, 2023     https://doi.org/10.3892/br.2023.1698
  • Article Number: 10
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Resolvin D1 (RvD1) represses inflammation, oxidative damage and neural injury related to acute ischemic stroke (AIS) progression. The present study aimed to explore the association of serum RvD1 with disease features, neurological recovery and prognosis in patients with AIS. A total of 212 patients with newly diagnosed AIS, whose serum RvD1 was quantified at admission and at discharge using an ELISA were enrolled in the current study. The modified Rankin scale (mRS) score was noted at 3 months after patient enrolment (M3), and patients were followed up for a median duration of 11.4 (range, 1.1‑21.0) months. The median RvD1 in patients with AIS at admission was 1.07 (range, 0.11‑9.29) ng/ml and it was negatively correlated with the neutrophil/lymphocyte ratio (r=‑0.160; P=0.009) and C‑reactive protein level (r=‑0.272; P<0.001), but it was not correlated with comorbidities or other biochemical indexes. RvD1 at admission was lower in patients with mRS >2 at M3 (P=0.001), recurrence (P=0.001) or death (P=0.032) compared with that in patients without the aforementioned characteristics, which had a general ability to estimate mRS >2 at M3 [area under curve (AUC), 0.633], as well as lower risk of recurrence (AUC, 0.745) and death (AUC, 0.757) according to receiver operator characteristic (ROC) curve analyses. The median RvD1 was raised to 1.70 (range, 0.30‑16.62) ng/ml at discharge. RvD1 at discharge was able to forecast mRS >2 at M3 (AUC, 0.678) and was able to predict the risk of recurrence (AUC, 0.796) and death (AUC, 0.826) in the ROC curve analyses. Increased serum RvD1 was associated with an attenuated inflammation status, and predicted improved neurological recovery, and lower risk of recurrence and death in patients with AIS. More specifically, its level at discharge exhibits a better prognostic utility than that at admission.
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Spandidos Publications style
Chen E, Zhou D and Deng R: Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomed Rep 20: 10, 2024
APA
Chen, E., Zhou, D., & Deng, R. (2024). Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke. Biomedical Reports, 20, 10. https://doi.org/10.3892/br.2023.1698
MLA
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20.1 (2024): 10.
Chicago
Chen, E., Zhou, D., Deng, R."Serum resolvin D1 potentially predicts neurofunctional recovery, the risk of recurrence and death in patients with acute ischemic stroke". Biomedical Reports 20, no. 1 (2024): 10. https://doi.org/10.3892/br.2023.1698