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Article Open Access

Ethanol extract of Rubia yunnanensis inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway

  • Authors:
    • Gaoyizhou Li
    • Jianghao Cheng
    • Liping Yang
    • Pu Chen
    • Xiaohua Duan
  • View Affiliations / Copyright

    Affiliations: Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 19
    |
    Published online on: December 8, 2023
       https://doi.org/10.3892/br.2023.1707
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Abstract

Atherosclerosis is a multifactorial vascular disease caused by endothelial dysfunction. Because of adverse reactions to drugs used to treat atherosclerosis. For example, statins, which significantly reduce the burden of atherosclerotic disease, have been associated with muscle toxicity. There is a need to identify novel drugs for the prevention and treatment of atherosclerosis Rubia yunnanensis is a herbs commonly used in Asian countries for its protective effects against cardiovascular diseases. However, the mechanism of action of R. yunnanensis extract in carotid artery atherosclerosis has not been found. The carotid artery is usually used as a site for clinical evaluation of atherosclerosis. The present study aimed to determine the mechanism of action of R. yunnanensis extract in the inhibition of carotid atherosclerosis in apolipoprotein E gene knockout (ApoE‑/‑) mice. The mechanism of atherosclerosis inhibition was elucidated by detecting the blood lipid level, carotid artery pathology, and the protein expression of PI3K and AKT. The present study demonstrated that ethanol extract of R. yunnanensis reduced lipid levels, intima damage and carotid lipid accumulation and increased p‑PI3K/PI3K and p‑AKT/AKT protein levels in ApoE‑/‑ mice fed high‑fat diet for 12 weeks. It was hypothesized that the effects of R. yunnanensis extract may be achieved by regulation of the phosphatidylinositol‑3‑kinase/protein kinase B signaling pathway. Ethanol extract of R. yunnanensis decreased carotid atherosclerosis in ApoE‑/‑ mice fed a high‑fat diet via the phosphatidylinositol‑3‑kinase/protein kinase B signaling pathway. Therefore, R. yunnanensis may be a promising option for treating atherosclerosis in the future.
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1 

Chen J, Zhang X, Millican R, Sherwood J, Martin S, Jo H, Yoon YS, Brott BC and Jun HW: Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis. Adv Drug Deliv Rev. 170:142–199. 2021.PubMed/NCBI View Article : Google Scholar

2 

Legein B, Temmerman L, Biessen EA and Lutgens E: Inflammation and immune system interactions in atherosclerosis. Cell Mol Life Sci. 70:3847–3869. 2013.PubMed/NCBI View Article : Google Scholar

3 

Geovanini GR and Libby P: Atherosclerosis and inflammation: Overview and updates. Clin Sci (Lond). 132:1243–1252. 2018.PubMed/NCBI View Article : Google Scholar

4 

Usai MV, Bosiers MJ, Bisdas T, Torsello G, Beropoulis E, Kasprzak B, Stachmann A and Stavroulakis K: Surgical versus endovascular revascularization of subclavian artery arteriosclerotic disease. J Cardiovasc Surg (Torino). 61:53–59. 2020.PubMed/NCBI View Article : Google Scholar

5 

Sun Y, Gao Y, Zhou L, Lu Y, Zong Y, Zhu H, Tang Y, Zheng F, Sun Y and Li Y: A multi-target protective effect of Danggui-Shaoyao-San on the vascular endothelium of atherosclerotic mice. BMC Complement Med Ther. 23(60)2023.PubMed/NCBI View Article : Google Scholar

6 

Lusis AJ: Atherosclerosis. Nature. 407:233–241. 2000.PubMed/NCBI View Article : Google Scholar

7 

Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352:1685–1695. 2005.PubMed/NCBI View Article : Google Scholar

8 

Williams IL, Wheatcroft SB, Shah AM and Kearney MT: Obesity, atherosclerosis and the vascular endothelium: Mechanisms of reduced nitric oxide bioavailability in obese humans. Int J Obes Relat Metab Disord. 26:754–764. 2002.PubMed/NCBI View Article : Google Scholar

9 

Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, et al: Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway. Vascul Pharmacol. 72:141–152. 2015.PubMed/NCBI View Article : Google Scholar

10 

Zhang R, Miao Y, Chen L, Yi S and Tan N: De Novo transcriptome analysis reveals putative genes involved in anthraquinone biosynthesis in Rubia yunnanensis. Genes (Basel). 13(521)2022.PubMed/NCBI View Article : Google Scholar

11 

Yi S, Lin Q, Zhang X, Wang J, Miao Y and Tan N: Selection and validation of appropriate reference genes for quantitative RT-PCR analysis in Rubia yunnanensis diels based on transcriptome data. Biomed Res Int. 2020(5824841)2020.PubMed/NCBI View Article : Google Scholar

12 

Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer JR and Theilmeier G: Hepatic overexpression of soluble urokinase receptor (uPAR) suppresses diet-induced atherosclerosis in low-density lipoprotein receptor-deficient (LDLR-/-) mice. PLoS One. 10(e0131854)2015.PubMed/NCBI View Article : Google Scholar

13 

Liu S, Liu Y, Liu Z, Hu Y and Jiang M: A review of the signaling pathways of aerobic and anaerobic exercise on atherosclerosis. J Cell Physiol. 238:866–879. 2023.PubMed/NCBI View Article : Google Scholar

14 

Zhou ZX, Ren Z, Yan BJ, Qu SL, Tang ZH, Wei DH, Liu LS, Fu MG and Jiang ZS: The role of ubiquitin E3 ligase in atherosclerosis. Curr Med Chem. 28:152–168. 2021.PubMed/NCBI View Article : Google Scholar

15 

Kolovou G, Anagnostopoulou K, Mikhailidis DP and Cokkinos DV: Apolipoprotein E knockout models. Curr Pharm Des. 14:338–351. 2008.PubMed/NCBI View Article : Google Scholar

16 

Nakashima Y, Plump AS, Raines EW, Breslow JL and Ross R: ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 14:133–140. 1994.PubMed/NCBI View Article : Google Scholar

17 

Gao Y, Su Y, Huo Y, Mi J, Wang X, Wang Z, Liu Y and Zhang H: Identification of antihyperlipidemic constituents from the roots of Rubia yunnanensis Diels. J Ethnopharmacol. 55:1315–1321. 2014.PubMed/NCBI View Article : Google Scholar

18 

Liou MJ and Wu TS: Triterpenoids from Rubia yunnanensis. J Nat Prod. 65:1283–1287. 2002.PubMed/NCBI View Article : Google Scholar

19 

Ren H, Wang X, Gao L, Niu L and Li J: Characteristic spectrum and quantitative study of the index components of the Yi medicine Rubia yunnanensis. Chin Med Mater. 45:1400–1404. 2022.PubMed/NCBI View Article : Google Scholar : (In Chinese).

20 

Yang R, Powell-Braxton L, Ogaoawara AK, Dybdal N, Bunting S, Ohneda O and Jin H: Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 19:2762–2768. 1999.PubMed/NCBI View Article : Google Scholar

21 

Nader MA, el-Agamy DS and Suddek GM: Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res. 33:637–643. 2010.PubMed/NCBI View Article : Google Scholar

22 

Calan M, Calan O, Gonen MS, Bilgir F, Kebapcilar L, Kulac E, Cinali T and Bilgir O: Examination of adhesion molecules, homocysteine and hs-CRP in patients with polygenic hypercholesterolemia and isolated hypertriglyceridemia. Intern Med. 50:1529–1535. 2011.PubMed/NCBI View Article : Google Scholar

23 

Meyer-Lindemann U, Mauersberger C, Schmidt AC, Moggio A, Hinterdobler J, Li X, Khangholi D, Hettwer J, Gräßer C, Dutsch A, et al: Colchicine Impacts leukocyte trafficking in atherosclerosis and reduces vascular inflammation. Front Immunol. 13(898690)2022.PubMed/NCBI View Article : Google Scholar

24 

Massberg S, Brand K, Gruner S, Page S, Müller E, Müller I, Bergmeier W, Richter T, Lorenz M, Konrad I, et al: A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med. 196:887–896. 2002.PubMed/NCBI View Article : Google Scholar

25 

Vega GL and Grundy SM: Hypercholesterolemia with cholesterol-enriched LDL and normal levels of LDL-apolipoprotein B. Effects of the step I diet and bile acid sequestrants on the cholesterol content of LDL. Arterioscler Thromb Vasc Biol. 16:517–522. 1996.PubMed/NCBI View Article : Google Scholar

26 

Badimon L, Vilahur G and Padro T: Lipoproteins, platelets and atherothrombosis. Rev Esp Cardiol. 62:1161–1178. 2009.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

27 

Calabresi L, Gomaraschi M, Simonelli S, Bernini F and Franceschini G: HDL and atherosclerosis: Insights from inherited HDL disorders. Biochim Biophys Acta. 1851:13–18. 2015.PubMed/NCBI View Article : Google Scholar

28 

Gimbrone MA Jr and Garcia-Cardena G: Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 118:620–636. 2016.PubMed/NCBI View Article : Google Scholar

29 

Aird WC: Endothelium as an organ system. Crit Care Med. 32 (5 Suppl):S271–S279. 2004.PubMed/NCBI View Article : Google Scholar

30 

Corre I, Paris F and Huot J: The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells. Oncotarget. 8:55684–55714. 2017.PubMed/NCBI View Article : Google Scholar

31 

Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A and Nasri H: Atherosclerosis: Process, indicators, risk factors and new hopes. Int J Prev Med. 5:927–946. 2014.PubMed/NCBI

32 

Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V and Orekhov AN: The diabetes mellitus-atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. Int J Mol Sci. 21(1835)2020.PubMed/NCBI View Article : Google Scholar

33 

Marchio P, Guerra-Ojeda S, Vila JM, Aldasoro M, Victor VM and Mauricio MD: targeting early atherosclerosis: A focus on oxidative stress and inflammation. Oxid Med Cell Longev. 2019(8563845)2019.PubMed/NCBI View Article : Google Scholar

34 

Li Y, Xu Q, Shi M, Gan P, Huang Q, Wang A, Tan G, Fang Y and Liao H: Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway. Microvasc Res. 129(103959)2020.PubMed/NCBI View Article : Google Scholar

35 

Chen L, Qin L, Liu X and Meng X: CTRP3 Alleviates Ox-LDL-Induced inflammatory response and endothelial dysfunction in mouse aortic endothelial cells by activating the PI3K/Akt/eNOS Pathway. Inflammation. 42:1350–1359. 2019.PubMed/NCBI View Article : Google Scholar

36 

Zhou YJ, Xu N, Zhang XC, Zhu YY, Liu SW and Chang YN: Chrysin improves glucose and lipid metabolism disorders by regulating the AMPK/PI3K/AKT signaling pathway in insulin-resistant HepG2 cells and HFD/STZ-Induced C57BL/6J mice. J Agric Food Chem. 69:5618–5627. 2021.PubMed/NCBI View Article : Google Scholar

37 

Manning BD and Toker A: AKT/PKB signaling: Navigating the network. Cell. 169:381–405. 2017.PubMed/NCBI View Article : Google Scholar

38 

Li Q, Li N, Cui HH, Tian XQ, Jin C, Chen GH and Yang YJ: Tongxinluo exerts protective effects via anti-apoptotic and pro-autophagic mechanisms by activating AMPK pathway in infarcted rat hearts. Exp Physiol. 102:422–435. 2017.PubMed/NCBI View Article : Google Scholar

39 

Jing R, Zhong QQ, Long TY, Pan W and Qian ZX: Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 23:4940–4947. 2019.PubMed/NCBI View Article : Google Scholar

40 

Liu J, Xu P, Liu D, Wang R, Cui S, Zhang Q, Li Y, Yang W and Zhang D: TCM Regulates PI3K/Akt signal pathway to intervene atherosclerotic cardiovascular disease. Evid Based Complement Alternat Med. 2021(4854755)2021.PubMed/NCBI View Article : Google Scholar

41 

Luo L, Liang H and Liu L: Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway. Pharm Biol. 60:56–64. 2022.PubMed/NCBI View Article : Google Scholar

42 

Guo J, Jie W, Shen Z, Li M, Lan Y, Kong Y, Guo S, Li T and Zheng S: SCF increases cardiac stem cell migration through PI3K/AKT and MMP-2/-9 signaling. Int J Mol Med. 34:112–118. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li G, Cheng J, Yang L, Chen P and Duan X: Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway. Biomed Rep 20: 19, 2024.
APA
Li, G., Cheng, J., Yang, L., Chen, P., & Duan, X. (2024). Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway. Biomedical Reports, 20, 19. https://doi.org/10.3892/br.2023.1707
MLA
Li, G., Cheng, J., Yang, L., Chen, P., Duan, X."Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway". Biomedical Reports 20.2 (2024): 19.
Chicago
Li, G., Cheng, J., Yang, L., Chen, P., Duan, X."Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway". Biomedical Reports 20, no. 2 (2024): 19. https://doi.org/10.3892/br.2023.1707
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Cheng J, Yang L, Chen P and Duan X: Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway. Biomed Rep 20: 19, 2024.
APA
Li, G., Cheng, J., Yang, L., Chen, P., & Duan, X. (2024). Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway. Biomedical Reports, 20, 19. https://doi.org/10.3892/br.2023.1707
MLA
Li, G., Cheng, J., Yang, L., Chen, P., Duan, X."Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway". Biomedical Reports 20.2 (2024): 19.
Chicago
Li, G., Cheng, J., Yang, L., Chen, P., Duan, X."Ethanol extract of <em>Rubia yunnanensis</em> inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway". Biomedical Reports 20, no. 2 (2024): 19. https://doi.org/10.3892/br.2023.1707
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