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Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma

  • Authors:
    • Hualan Hong
    • Xi Shi
    • Wenyong Ou
    • Pengju Ou
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, P.R. China, Department of Surgery 1, Longyan People Hospital, Longyan, Fujian 364000, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 63
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    Published online on: February 19, 2024
       https://doi.org/10.3892/br.2024.1751
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Abstract

The role and underlying mechanism of cytoplasmic polyadenylation element binding protein 3 (CPEB3) in clear cell renal cell carcinoma [ccRCC progression remain poorly characterized. The present study was designed to evaluate the role of CPEB3 in ccRCC and its clinical associations. The overall response rate of first-line therapies (ICIs combined with VEGFR-TKIs or ICI combination) for ccRCC] is 42.0-59.3%, so a number of patients with ccRCC do not benefit from these therapies. To avoid immunosurveillance and immune killing, tumor cells decrease immunogenicity and recruit immunosuppressive cells such as regulatory T cells (Tregs). Tregs inhibit the development of anti-tumor immunity, thereby hindering immune surveillance of cancer and preventing effective anti-tumor immune response in tumor-bearing hosts. The present study analyzed clinical specimens from patients ccRCC and then examined the role of CPEB3 in ccRCC via bioinformatics analysis. CPEB3 expression was significantly reduced in ccRCC compared with normal tissue and low CPEB3 expression was associated with poor overall survival. Moreover, CPEB3 expression was an independent predictor of survival. CPEB3 expression was positively associated with immune biomarkers [CD274, programmed cell death 1 ligand 2, Hepatitis a virus cellular receptor 2, Chemokine (C-X-C motif) ligand (CXCL)9, CXCL10, Inducible T cell costimulatory, CD40, CD80 and CD38] that improve the outcome of anti-tumor immune responses. CPEB3 expression in ccRCC also affected the status of 24 types of infiltrating immune cell, of which Tregs were the most significantly negatively correlated cell type. CPEB3 may serve as a prognostic biomarker in ccRCC and its mechanism may be related to the regulation of Tregs.
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Copy and paste a formatted citation
Spandidos Publications style
Hong H, Shi X, Ou W and Ou P: Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma. Biomed Rep 20: 63, 2024.
APA
Hong, H., Shi, X., Ou, W., & Ou, P. (2024). Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma. Biomedical Reports, 20, 63. https://doi.org/10.3892/br.2024.1751
MLA
Hong, H., Shi, X., Ou, W., Ou, P."Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma". Biomedical Reports 20.4 (2024): 63.
Chicago
Hong, H., Shi, X., Ou, W., Ou, P."Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma". Biomedical Reports 20, no. 4 (2024): 63. https://doi.org/10.3892/br.2024.1751
Copy and paste a formatted citation
x
Spandidos Publications style
Hong H, Shi X, Ou W and Ou P: Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma. Biomed Rep 20: 63, 2024.
APA
Hong, H., Shi, X., Ou, W., & Ou, P. (2024). Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma. Biomedical Reports, 20, 63. https://doi.org/10.3892/br.2024.1751
MLA
Hong, H., Shi, X., Ou, W., Ou, P."Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma". Biomedical Reports 20.4 (2024): 63.
Chicago
Hong, H., Shi, X., Ou, W., Ou, P."Prognostic biomarker CPEB3 and its associations with immune infiltration in clear cell renal cell carcinoma". Biomedical Reports 20, no. 4 (2024): 63. https://doi.org/10.3892/br.2024.1751
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