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Case Report Open Access

Acute organic solvent toxic encephalopathy: A case report and literature review

  • Authors:
    • Yinjiao Wang
    • Peng Du
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
    |
    Published online on: September 3, 2024
       https://doi.org/10.3892/br.2024.1851
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Abstract

Organic solvents are a class of volatile, lipophilic substances that can easily enter the human body through skin and mucous membrane contact as well as air inhalation, and can lead to toxic encephalopathy (TE), especially after entering the lipid‑rich nervous system. The present case reports a patient with acute organic solvent toxic encephalopathy (AOSTE), which may have been caused by occasional ink leakage from Xuzhou (Jiangsu, China). By summarizing the history the patient to exposure to organic solvents, clinical manifestations, radiology findings and relevant laboratory tests, we hypothesize that a history of ink exposure, brain magnetic resonance imaging findings and hippuric acid testing were indispensable factors in the diagnosis of AOSTE. After neurological treatment, the patient experienced notable improvement in symptoms. The present study reports on its clinical features, imaging features, treatment and follow‑up, and review relevant literature to summarize its clinical experience, hoping to improve our understanding of AOSTE.
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1 

Dobbs MR: Toxic encephalopathy. Semin Neurol. 31:184–193. 2011.PubMed/NCBI View Article : Google Scholar

2 

Agarwal A and Vancil T: Toxic encephalopathy. J Gen Intern Med. 27:876–877. 2012.PubMed/NCBI View Article : Google Scholar

3 

Li XL, Zhao HT, Han J, Yan ZR and Wang HY: Toxic encephalopathy induced by radix Sophorae tonkinensis. Acta Neurol Belg. 122:855–858. 2022.PubMed/NCBI View Article : Google Scholar

4 

Sainio MA Sr: Neurotoxicity of solvents. Handb Clin Neurol. 131:93–110. 2015.PubMed/NCBI View Article : Google Scholar

5 

Ikeda M: Public health problems of organic solvents. Toxicol Lett. 64-65:191–201. 1992.PubMed/NCBI View Article : Google Scholar

6 

Hedström AK, Hössjer O, Katsoulis M, Kockum I, Olsson T and Alfredsson L: Organic solvents and MS susceptibility: Interaction with MS risk HLA genes. Neurology. 91:e455–e462. 2018.PubMed/NCBI View Article : Google Scholar

7 

Filley CM, Halliday W and Kleinschmidt-DeMasters BK: The effects of toluene on the central nervous system. J Neuropathol Exp Neurol. 63:1–12. 2004.PubMed/NCBI View Article : Google Scholar

8 

Win-Shwe TT and Fujimaki H: Neurotoxicity of toluene. Toxicol Lett. 198:93–99. 2010.PubMed/NCBI View Article : Google Scholar

9 

Greenberg MM: The central nervous system and exposure to toluene: A risk characterization. Environ Res. 72:1–7. 1997.PubMed/NCBI View Article : Google Scholar

10 

Ridgway P, Nixon TE and Leach JP: Occupational exposure to organic solvents and long-term nervous system damage detectable by brain imaging, neurophysiology or histopathology. Food Chem Toxicol. 41:153–187. 2003.PubMed/NCBI View Article : Google Scholar

11 

Eaker EY, Shaw G and Sninsky CA: Neurofilament immunoreactivity in myenteric neurons differs from that found in the central nervous system. Gastroenterology. 99:1364–1371. 1990.PubMed/NCBI View Article : Google Scholar

12 

Heimfarth L, Passos FRS, Monteiro BS, Araújo AAS, Quintans Júnior LJ and Quintans JSS: Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease-A systematic review. Int Immunopharmacol. 107(108624)2022.PubMed/NCBI View Article : Google Scholar

13 

Shum MW and Hon JK: A modified phosphotungstic acid haematoxylin stain for formalin-fixed tissues. J Med Lab Technol. 26:38–42. 1969.PubMed/NCBI

14 

Oginawati K, Anka AAH, Susetyo SH, Febriana SA, Tanziha I and Prakoeswa CRS: Urinary hippuric acid level as a biological indicator of toluene exposure on batik workers. Heliyon. 7(e07775)2021.PubMed/NCBI View Article : Google Scholar

15 

Shan X, Zhang L, Ye H, Shao J, Shi Y, Tan S, Zhang L and Su K: Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples. Bioanalysis. 13:1569–1584. 2021.PubMed/NCBI View Article : Google Scholar

16 

Keski-Säntti P, Kovala T, Holm A, Hyvärinen HK and Sainio M: Quantitative EEG in occupational chronic solvent encephalopathy. Hum Exp Toxicol. 27:315–320. 2008.PubMed/NCBI View Article : Google Scholar

17 

Aydin K, Sencer S, Demir T, Ogel K, Tunaci A and Minareci O: Cranial MR findings in chronic toluene abuse by inhalation. AJNR Am J Neuroradiol. 23:1173–1179. 2002.PubMed/NCBI

18 

Mi T, Han C, Wang Y, Ma H, Jia J, Ding Y, Esmail F, Chen J, Peng L, Xu J and Sun YX: Acute toxic leukoencephalopathy in migrant workers exposed to organic solvents in construction materials. Occup Environ Med. 70:435–436. 2013.PubMed/NCBI View Article : Google Scholar

19 

Liu JR, Fang S, Ding MP, Chen ZC, Zhou JJ, Sun F, Jiang B and Huang J: Toxic encephalopathy caused by occupational exposure to 1, 2-Dichloroethane. J Neurol Sci. 292:111–113. 2010.PubMed/NCBI View Article : Google Scholar

20 

Dick FD: Solvent neurotoxicity. Occup Environ Med. 63:221–179. 2006.PubMed/NCBI View Article : Google Scholar

21 

Mahavar S, Chaturvedi A, Singh A, Kumar R, Dariya SS and Sharma R: Toluene poisoning presenting as bilateral basal ganglia haemorrhage. J Assoc Physicians India. 66:93–94. 2018.PubMed/NCBI

22 

Basant N, Gupta S and Singh KP: Predicting the acute neurotoxicity of diverse organic solvents using probabilistic neural networks based QSTR modeling approaches. Neurotoxicology. 53:45–52. 2016.PubMed/NCBI View Article : Google Scholar

23 

Gaosheng X, Tao J and Min M: The analysis of clinical and imaging features in 15 patients with occupational organic solvent poisoning. Stroke Nervous Dis. 28:672–675. 2021.(In Chinese).

24 

Liu J, Zhang L, He B, Zhuang JH, Xu J, Huang LY and Peng H: Roles of neuroimage in toxic encephalopathy induced by 1, 2-Dichloroethane. Clin Neurol Neurosurg. 184(105398)2019.PubMed/NCBI View Article : Google Scholar

25 

Dietemann JL, Botelho C, Nogueira T, Vargas MI, Audibert C, Abu Eid M, Bogorin A, Bernardo R, Jacques C, Kremer S and Zöllner G: Imagerie des encephalopathies toxiques aigues Imaging in acute toxic encephalopathy. J Neuroradiol. 31:313–326. 2004.PubMed/NCBI View Article : Google Scholar : (In French).

26 

Keski-Säntti P, Mäntylä R, Lamminen A, Hyvärinen HK and Sainio M: Magnetic resonance imaging in occupational chronic solvent encephalopathy. Int Arch Occup Environ Health. 82:595–602. 2009.PubMed/NCBI View Article : Google Scholar

27 

He L, Kong D and Jing H: Analysis on clinical characteristics of five cases of sub-acute organic solvent poisoning nervous system injuries. Chin J Industrial Med. 36:326–328. 2023.(In Chinese).

28 

Donoghue AM, Dryson EW and Wynn-Williams G: Contrast sensitivity in organic-solvent-induced chronic toxic encephalopathy. J Occup Environ Med. 37:1357–1363. 1995.PubMed/NCBI View Article : Google Scholar

29 

Seo S and Kim J: An aggravated return-to-work case of organic solvent induced chronic toxic encephalopathy. Ann Occup Environ Med. 30(27)2018.PubMed/NCBI View Article : Google Scholar

30 

Baker EL: Chronic toxic encephalopathy caused by occupational solvent exposure. Ann Neurol. 63:545–547. 2008.PubMed/NCBI View Article : Google Scholar

31 

Van Valen E, van Thriel C, Akila R, Nilson LN, Bast-Pettersen R, Sainio M, van Dijk F, van der Laan G, Verberk M and Wekking E: Chronic solvent-induced encephalopathy: European consensus of neuropsychological characteristics, assessment, and guidelines for diagnostics. Neurotoxicology. 33:710–726. 2012.PubMed/NCBI View Article : Google Scholar

32 

Zheng X: Imaging features of acute and subacute toxic encephalopathy induced by organic solvents. J Practical Radiology. 40:19–21. 2024.

33 

Biswas S, Pendharkar HS and Murumkar VS: MRI Spectrum of toxic encephalopathy-an institutional experience. Neurol India. 70:1525–1533. 2022.PubMed/NCBI View Article : Google Scholar

34 

Wang X, Li Z, Berglass J, He W, Zhao J, Zhang M, Gao C, Zhang C, Zhang H and Yi X: MRI and clinical manifestations of delayed encephalopathy after carbon monoxide poisoning. Pak J Pharm Sci. 29 (Suppl 6):S2317–S2320. 2016.PubMed/NCBI

35 

Sone J, Mori K, Inagaki T, Katsumata R, Takagi S, Yokoi S, Araki K, Kato T, Nakamura T, Koike H, et al: Clinicopathological features of adult-onset neuronal intranuclear inclusion disease. Brain. 139:3170–3186. 2016.PubMed/NCBI View Article : Google Scholar

36 

Mulligan C and Bronstein JM: Wilson disease: An overview and approach to management. Neurol Clin. 38:417–432. 2020.PubMed/NCBI View Article : Google Scholar

37 

Bandmann O, Weiss KH and Kaler SG: Wilson's disease and other neurological copper disorders. Lancet Neurol. 14:103–113. 2015.PubMed/NCBI View Article : Google Scholar

38 

Panda AK, Mehta VJ, Dung AA and Kushwaha S: Face of giant panda sign in Wilson's disease. J Assoc Physicians India. 62:707–708. 2014.PubMed/NCBI

39 

Haibing Z, Guilan O and Yanwei L: Clinical characteristics of occupational acute organic solvent poisoning encephalopathy. J Gannan Med Univ. 40:891–895. 2020.

40 

Chuan F and Xianwen C: Research progress on organic solvent toxic encephalopathy. Chin J Neurol. 47:55–58. 2014.

41 

Mestdagh I, van Bergen L, Kocken C, Heyvaert V, Cras P and Van Den Eede F: Diagnosing solvent-induced chronic toxic encephalopathy: The effect of underperformance in neuropsychological testing. Int J Psychiatry Clin Pract. 23:171–177. 2019.PubMed/NCBI View Article : Google Scholar

42 

Dryson EW and Ogden JA: Organic solvent induced chronic toxic encephalopathy: Extent of recovery, and associated factors, following cessation of exposure. Neurotoxicology. 21:659–665. 2000.PubMed/NCBI

43 

Van Valen E, van Hout ES, Wekking EM, Lenderink AF, van der Laan G and Hageman G: Brain damage caused by exposure to organic solvents; diagnostics and disease course of chronic solvent-induced encephalopathy. Ned Tijdschr Geneeskd. 159(A9431)2015.PubMed/NCBI

44 

Van Valen E, Wekking E, van der Laan G, Sprangers M and van Dijk F: The course of chronic solvent induced encephalopathy: A systematic review. Neurotoxicology. 30:1172–1186. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y and Du P: Acute organic solvent toxic encephalopathy: A case report and literature review. Biomed Rep 21: 163, 2024.
APA
Wang, Y., & Du, P. (2024). Acute organic solvent toxic encephalopathy: A case report and literature review. Biomedical Reports, 21, 163. https://doi.org/10.3892/br.2024.1851
MLA
Wang, Y., Du, P."Acute organic solvent toxic encephalopathy: A case report and literature review". Biomedical Reports 21.5 (2024): 163.
Chicago
Wang, Y., Du, P."Acute organic solvent toxic encephalopathy: A case report and literature review". Biomedical Reports 21, no. 5 (2024): 163. https://doi.org/10.3892/br.2024.1851
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y and Du P: Acute organic solvent toxic encephalopathy: A case report and literature review. Biomed Rep 21: 163, 2024.
APA
Wang, Y., & Du, P. (2024). Acute organic solvent toxic encephalopathy: A case report and literature review. Biomedical Reports, 21, 163. https://doi.org/10.3892/br.2024.1851
MLA
Wang, Y., Du, P."Acute organic solvent toxic encephalopathy: A case report and literature review". Biomedical Reports 21.5 (2024): 163.
Chicago
Wang, Y., Du, P."Acute organic solvent toxic encephalopathy: A case report and literature review". Biomedical Reports 21, no. 5 (2024): 163. https://doi.org/10.3892/br.2024.1851
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