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Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses

  • Authors:
    • Fuhui Li
    • Jie Tao
    • Mingmin Zhou
    • Xingzhi Yu
    • Tian Xiao
    • Chaoliang Wang
    • Xiaohua Duan
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    Affiliations: College of Notoginseng Medicine, Wenshan University, Wenshan, Yunnan 663099, P.R. China, Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China
  • Published online on: October 9, 2024     https://doi.org/10.3892/br.2024.1875
  • Article Number: 187
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In order to study the mechanisms of ginsenoside Rb3 (G‑Rb3) against oxygen‑glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells based on metabolomics and PCR array, HT22 cells were randomly divided into control group, model group, G‑Rb3 high‑dose group (10 µmol/l) and G‑Rb3 low‑dose group (5 µmol/l). Except for the control group, which was left untreated, the remaining groups were incubated with 10 mmol/l Na2S2O4 in sugar‑free DMEM medium for 2 h and then replaced with serum‑free high‑sugar DMEM medium for 2 h in order to replicate in vitro OGD/R model. Trypan blue staining was used to detect the cell viability; flow cytometry was used to detect apoptosis; western blotting was used to detect the protein expression levels of Bax, Bcl‑2 and caspase‑3. The metabolomics were used to analyze the differential metabolites of G‑Rb3 affecting OGD/R in order to find the relevant metabolic pathways. PCR array assay was performed to identify the expression of the differential genes. G‑Rb3 could inhibit HT22 apoptosis according to the result of cell morphology, trypan blue staining and flow cytometry. The levels of Bax and caspase‑3 protein expression were decreased, whereas the level of Bcl‑2 protein expression was increased after the treatment of G‑Rb3. Metabolomics results showed that a total of 31 differential metabolites between OGD/R group and G‑Rb3 group, such as guanosine level, was downregulated, the levels of enalaprilat and sorbitol were upregulated, affecting ABC transporters, galactose metabolism, citrate cycle and other related metabolic pathways; according to the result of PCR array, it was observed that G‑Rb3 significantly downregulated Trp63, Trp73, Dapk1, Casp14 and Cd70 pro‑apoptotic genes. In conclusion, G‑Rb3 has a significant protective effect on the OGD/R model simulated in vitro, and the mechanism may be related to the inhibition of apoptosis by affecting metabolites.
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1 

Markus HS: Stroke genetics. Hum Mol Genet. 20:R124–R131. 2011.PubMed/NCBI View Article : Google Scholar

2 

Abbas M, Malicke DT and Schramski JT: Stroke anticoagulation. In: StatPearls. StatPearls Publishing, Treasure Island, FL, 2024.

3 

Campbell BCV and Khatri P: Stroke. Lancet. 396:129–142. 2020.PubMed/NCBI View Article : Google Scholar

4 

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM and Donnan GA: Ischaemic stroke. Nat Rev Dis Primers. 5(70)2019.PubMed/NCBI View Article : Google Scholar

5 

Xu C, Wang W, Wang B, Zhang T, Cui X, Pu Y and Li N: Analytical methods and biological activities of Panax notoginseng saponins: Recent trends. J Ethnopharmacol. 236:443–465. 2019.PubMed/NCBI View Article : Google Scholar

6 

Liang Z, Liu K, Li R, Ma B, Zheng W, Yang S, Zhang G, Zhao Y, Chen J and Zhao M: An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng. Front Nutr. 9(1058639)2022.PubMed/NCBI View Article : Google Scholar

7 

Chen XM, Chen HS, Xu MJ and Shen JG: Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta pharmacologica Sin. 34:67–77. 2013.PubMed/NCBI View Article : Google Scholar

8 

Thorén M, Dixit A, Escudero-Martínez I, Gdovinová Z, Klecka L, Rand VM, Toni D, Vilionskis A, Wahlgren N and Ahmed N: Effect of recanalization on cerebral edema in ischemic stroke treated with thrombolysis and/or endovascular therapy. Stroke. 51:216–223. 2020.PubMed/NCBI View Article : Google Scholar

9 

Takahashi H, Yamamoto T and Tsuboi A: Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain. Neurosci Res. 186:3–9. 2023.PubMed/NCBI View Article : Google Scholar

10 

Zheng MM, Zhang F and Zhang Q: Research progress in biological activity of ginsenoside Rb3. Central South Pharm. 9:1249–1252. 2017.(In Chinese).

11 

Liu X, Jiang Y, Yu X, Fu W, Zhang H and Sui D: Ginsenoside-Rb3 protects the myocardium from ischemia-reperfusion injury via the inhibition of apoptosis in rats. Exp Ther Med. 8:1751–1756. 2014.PubMed/NCBI View Article : Google Scholar

12 

Kim DH, Kim DW, Jung BH, Lee JH, Lee H, Hwang GS, Kang KS and Lee JW: Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells. J Ginseng Res. 43:326–334. 2019.PubMed/NCBI View Article : Google Scholar

13 

Qian T, Cai Z, Wong RNS, Mak NK and Jiang ZH: In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3. J Chromatogr B Analyt Technol Biomed Life Sci. 816:223–232. 2005.PubMed/NCBI View Article : Google Scholar

14 

Qian T, Cai Z, Wong RNS and Jiang ZH: Liquid chromatography/mass spectrometric analysis of rat samples for in vivo metabolism and pharmacokinetic studies of ginsenoside Rh2. Rapid Commun Mass Spectrom. 19:3549–3554. 2005.PubMed/NCBI View Article : Google Scholar

15 

Zhou S, Gao X, Chen C, Zhang J, Zhang Y, Zhang L and Yan X: Porcine cardiac blood-Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K/AKT/Bcl-2/Bax signaling pathway. J Ethnopharmacol. 316(116698)2023.PubMed/NCBI View Article : Google Scholar

16 

Yuan Y, Tian Y, Jiang H, Cai LY, Song J, Peng R and Zhang XM: Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia-reperfusion injury. Front Mol Neurosci. 16(1224964)2023.PubMed/NCBI View Article : Google Scholar

17 

Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD and McLean JA: Untargeted metabolomics strategies-challenges and emerging directions. J Am Soc Mass Spectrom. 27:1897–1905. 2016.PubMed/NCBI View Article : Google Scholar

18 

Wishart DS: Metabolomics for investigating physiological and pathophysiological processes. Physiol Rev. 99:1819–1875. 2019.PubMed/NCBI View Article : Google Scholar

19 

Smith CA, Want EJ, O'Maille G, Abagyan R and Siuzdak G: XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem. 78:779–787. 2006.PubMed/NCBI View Article : Google Scholar

20 

Navarro-Reig M, Jaumot J, García-Reiriz A and Tauler R: Evaluation of changes induced in rice metabolome by Cd and Cu exposure using LC-MS with XCMS and MCR-ALS data analysis strategies. Anal Bioanal Chem. 407:8835–8847. 2015.PubMed/NCBI View Article : Google Scholar

21 

Cheng J, Li G, Yang L, Chen P and Duan X: Alcohol extract of Rubia yunnanensis: Metabolic alterations and preventive effects against OGD/R-induced oxidative damage in HT22 cells. Biomed Rep. 20(75)2024.PubMed/NCBI View Article : Google Scholar

22 

Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, et al: HMDB: The human metabolome database. Nucleic Acids Res. 35 (Database Issue):D521–D526. 2007.PubMed/NCBI View Article : Google Scholar

23 

Horai H, Arita M, Kanaya S, Nihei Y, Ikeda T, Suwa K, Ojima Y, Tanaka K, Tanaka S, Aoshima K, et al: MassBank: A public repository for sharing mass spectral data for life sciences. J Mass Spectrom. 45:703–714. 2010.PubMed/NCBI View Article : Google Scholar

24 

Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH Jr, Murphy RC, Raetz CR, Russell DW and Subramaniam S: LMSD: LIPID MAPS structure database. Nucleic Acids Res. 35 (Database Issue):D527–D532. 2007.PubMed/NCBI View Article : Google Scholar

25 

Abdelrazig S, Safo L, Rance GA, Fay MW, Theodosiou E, Topham PD, Kim DH and Fernández-Castané A: Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling. RSC Adv. 10:32548–32560. 2020.PubMed/NCBI View Article : Google Scholar

26 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000.PubMed/NCBI View Article : Google Scholar

27 

Xia J and Wishart DS: Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nat Protoc. 6:743–760. 2011.PubMed/NCBI View Article : Google Scholar

28 

Barman J, Kumar R, Saha G, Tiwari K and Dubey VK: Apoptosis: Mediator molecules, interplay with other cell death processes and therapeutic potentials. Curr Pharm Biotechnol. 19:644–663. 2018.PubMed/NCBI View Article : Google Scholar

29 

Flores-Romero H, Ros U and Garcia-Saez AJ: Pore formation in regulated cell death. EMBO J. 39(e105753)2020.PubMed/NCBI View Article : Google Scholar

30 

Yuan J, Zeng L, Sun Y, Wang N, Sun Q, Cheng Z and Wang Y: SH2B1 protects against OGD/R-induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway. Mol Med Rep. 18:2613–2620. 2018.PubMed/NCBI View Article : Google Scholar

31 

Peña-Blanco A and García-Sáez AJ: Bax, Bak and beyond-mitochondrial performance in apoptosis. FEBS J. 285:416–431. 2018.PubMed/NCBI View Article : Google Scholar

32 

Brady HJ and Gil-Gómez G: Bax. The pro-apoptotic Bcl-2 family member, Bax. Int J Biochem Cell Biol. 30:647–650. 1998.PubMed/NCBI View Article : Google Scholar

33 

Edlich F: BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochem Biophys Res Commun. 500:26–34. 2018.PubMed/NCBI View Article : Google Scholar

34 

Trubiani O, Guarnieri S, Paganelli R and Di Primio R: Involvement of caspace-3 in the cleavage of terminal transferase. Int J Immunopathol Pharmacol. 15:201–208. 2002.PubMed/NCBI View Article : Google Scholar

35 

Dal-Cim T, Ludka FK, Martins WC, Reginato C, Parada E, Egea J, López MG and Tasca CI: Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. J Neurochem. 126:437–450. 2013.PubMed/NCBI View Article : Google Scholar

36 

Rathbone M, Pilutti L, Caciagli F and Jiang S: Neurotrophic effects of extracellular guanosine. Nucleosides Nucleotides Nucleic Acids. 27:666–672. 2008.PubMed/NCBI View Article : Google Scholar

37 

Oliveira KA, Dal-Cim TA, Lopes FG, Nedel CB and Tasca CI: Guanosine promotes cytotoxicity via adenosine receptors and induces apoptosis in temozolomide-treated A172 glioma cells. Purinergic Signal. 13:305–318. 2017.PubMed/NCBI View Article : Google Scholar

38 

Schneider EH, Hofmeister O, Kälble S and Seifert R: Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn Schmiedebergs Arch Pharmacol. 393:1251–1267. 2020.PubMed/NCBI View Article : Google Scholar

39 

Shwe T, Pratchayasakul W, Chattipakorn N and Chattipakorn SC: Role of D-galactose-induced brain aging and its potential used for therapeutic interventions. Exp Gerontol. 101:13–36. 2018.PubMed/NCBI View Article : Google Scholar

40 

Xue A, Zhao D, Zhao C, Li X, Yang M, Zhao H, Zhao C, Lei X, Wu J and Zhang N: Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy. J Ethnopharmacol. 318(117012)2024.PubMed/NCBI View Article : Google Scholar

41 

Kwon HJ, Hahn KR, Nam SM, Yoon YS, Moon SM, Hwang IK and Kim DW: Purpurin ameliorates D-galactose-induced aging phenotypes in mouse hippocampus by reducing inflammatory responses. Neurochem Int. 167(105552)2023.PubMed/NCBI View Article : Google Scholar

42 

Jabir NR, Firoz CK, Zughaibi TA, Alsaadi MA, Abuzenadah AM, Al-Asmari AI, Alsaieedi A, Ahmed BA, Ramu AK and Tabrez S: A literature perspective on the pharmacological applications of yohimbine. Ann Med. 54:2861–2875. 2022.PubMed/NCBI View Article : Google Scholar

43 

Bremer AM, Yamada K and West CR: Ischemic cerebral edema in primates: effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. Neurosurgery. 6:149–154. 1980.PubMed/NCBI View Article : Google Scholar

44 

Mailloux A, Deslandes B, Vaubourdolle M and Baudin B: Captopril and enalaprilat decrease antioxidant defences in human endothelial cells and are unable to protect against apoptosis. Cell Biol Int. 27:825–830. 2003.PubMed/NCBI View Article : Google Scholar

45 

Gomez HJ, Cirillo VJ and Irvin JD: Enalapril: A review of human pharmacology. Drugs. 30 (Suppl 1):S13–S24. 1985.PubMed/NCBI View Article : Google Scholar

46 

Niu JJ, Bai Lf and Hou CN: Comparison of therapeutic effects of captopril, enalapril and sodium nitroprusside on hypertension, 2018.

47 

Turovsky EA, Varlamova EG, Gudkov SV and Plotnikov EY: The protective mechanism of deuterated linoleic acid involves the activation of the Ca2+ signaling system of astrocytes in ischemia in vitro. Int J Mol Sci. 22(13216)2021.PubMed/NCBI View Article : Google Scholar

48 

Kenzelmann Broz D and Attardi LD: TRP53 activates a global autophagy program to promote tumor suppression. Autophagy. 9:1440–1442. 2013.PubMed/NCBI View Article : Google Scholar

49 

Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD and Kaplan DR: p63 is an essential proapoptotic protein during neural development. Neuron. 48:743–756. 2005.PubMed/NCBI View Article : Google Scholar

50 

Wei R, Zhang L, Hu W, Wu J and Zhang W: Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1. Exp Neurol. 314:100–110. 2019.PubMed/NCBI View Article : Google Scholar

51 

Markiewicz A, Sigorski D, Markiewicz M, Owczarczyk-Saczonek A and Placek W: Caspase-14-from biomolecular basics to clinical approach. A review of available data. Int J Mol Sci. 22(5575)2021.PubMed/NCBI View Article : Google Scholar

52 

Hoefsmit EP, van Royen PT, Rao D, Stunnenberg JA, Dimitriadis P, Lieftink C, Morris B, Rozeman EA, Reijers ILM, Lacroix R, et al: Inhibitor of apoptosis proteins antagonist induces T-cell Proliferation after cross-presentation by dendritic cells. Cancer Immunol Res. 11:450–465. 2023.PubMed/NCBI View Article : Google Scholar

53 

Sasnauskiene A, Kadziauskas J, Vezelyte N, Jonusiene V and Kirveliene V: Apoptosis, autophagy and cell cycle arrest following photodamage to mitochondrial interior. Apoptosis. 14:276–286. 2009.PubMed/NCBI View Article : Google Scholar

54 

Wensveen FM, Unger PPA, Kragten NAM, Derks IA, ten Brinke A, Arens R, van Lier RA, Eldering E and van Gisbergen KP: CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load. J Immunol. 188:4256–4267. 2012.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li F, Tao J, Zhou M, Yu X, Xiao T, Wang C and Duan X: Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses. Biomed Rep 21: 187, 2024.
APA
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., & Duan, X. (2024). Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses. Biomedical Reports, 21, 187. https://doi.org/10.3892/br.2024.1875
MLA
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., Duan, X."Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses". Biomedical Reports 21.6 (2024): 187.
Chicago
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., Duan, X."Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses". Biomedical Reports 21, no. 6 (2024): 187. https://doi.org/10.3892/br.2024.1875
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Tao J, Zhou M, Yu X, Xiao T, Wang C and Duan X: Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses. Biomed Rep 21: 187, 2024.
APA
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., & Duan, X. (2024). Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses. Biomedical Reports, 21, 187. https://doi.org/10.3892/br.2024.1875
MLA
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., Duan, X."Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses". Biomedical Reports 21.6 (2024): 187.
Chicago
Li, F., Tao, J., Zhou, M., Yu, X., Xiao, T., Wang, C., Duan, X."Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses". Biomedical Reports 21, no. 6 (2024): 187. https://doi.org/10.3892/br.2024.1875
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