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Article Open Access

Active fraction of ground cherry (Physalis angulata L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice

  • Authors:
    • Yanet Ocampo
    • Daneiva Caro
    • David Rivera
    • Jenny Castro
    • Indira Pájaro
    • Rubén Salas
    • Luis Franco
  • View Affiliations / Copyright

    Affiliations: Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, Universidad de Cartagena, Cartagena 130014, Colombia
    Copyright: © Ocampo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 188
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    Published online on: October 10, 2024
       https://doi.org/10.3892/br.2024.1876
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Abstract

Physalis angulata L., commonly known as wild tomato or ground cherry, is widely used in tropical and subtropical areas to treat health disorders including inflammation, hepatitis, dermatitis, cancer and diabetes. In Colombia, anti‑cancer and anti‑inflammatory activity are the most common ethnopharmacological applications of P. angulata calyces. P. angulata dichloromethane fraction (PADF) has significant anti‑inflammatory activity. The present study assessed the pharmacological effect of PADF on colorectal cancer (CRC) using cancer and normal human cells and an azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model. MTT and clonogenic assay, cell cycle and apoptosis analysis and mitochondrial membrane potential measurement were employed to evaluate in vitro activity of PADF. PADF selectively induced a cytotoxic effect against CRC cells via apoptosis and G2/M arrest. In the AOM/DSS model, treatment with PADF diminished tumor number and size, affected area and expression of proliferating cell nuclear antigen and promoted colon tissue repair. These effects might be related to the increased expression of p38 pro‑apoptotic protein in addition to anti‑inflammatory activity of PADF demonstrated by decreased levels of TNF‑α, IL‑6, and IL‑1β. PADF may serve as a potential treatment for CRC. Further investigation is warranted to identify the bioactive components in PADF.
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1 

Physalis-The Plant List. Version 1, 2010 [cited 2020 Feb 5]. Available from: http://www.theplantlist.org/browse/A/Solanaceae/Physalis/.

2 

Mazova N, Popova V and Stoyanova A: Phytochemical composition and biological activity of Physalis spp.: A mini-review. Food Sci Appl Biotechnol. 3:56–70. 2020.

3 

Zhang WN and Tong WY: Chemical constituents and biological activities of plants from the genus Physalis. Chem Biodivers. 13:48–65. 2016.PubMed/NCBI View Article : Google Scholar

4 

Rengifo-Salgado E and Vargas-Arana G: Physalis angulata L. (Bolsa Mullaca): A review of its traditional uses, chemistry and pharmacology. Bol Latinoam Caribe Plant Med Aromat. 12:431–445. 2013.

5 

Cobaleda-Velasco M, Alanis-Bañuelos RE, Almaraz-Abarca N, Rojas-López M, González-Valdez LS, Ávila-Reyes JA and Rodrigo S: Phenolic profiles and antioxidant properties of Physalis angulata L. as quality indicators. J Pharm Pharmacogn Res. 5:114–128. 2017.

6 

Rivera D, Ocampo Y and Franco LA: Physalis angulata calyces modulate macrophage polarization and alleviate chemically induced intestinal inflammation in mice. Biomedicines. 8(24)2020.PubMed/NCBI View Article : Google Scholar

7 

Iwansyah AC, Luthfiyanti R, Ardiansyah RCE, Rahman N, Andriana Y and Hamid HA: Antidiabetic activity of Physalis angulata L. fruit juice on streptozotocin-induced diabetic rats. S Afr J Bot. 145:313–319. 2022.

8 

Rivera DE, Ocampo YC, Castro JP, Caro D and Franco LA: Antibacterial activity of Physalis angulata L., Merremia umbellata L., and Cryptostegia grandiflora Roxb. Ex R.Br. -medicinal plants of the Colombian Northern Coast. Orient Pharm Exp Med. 15:95–102. 2015.

9 

Rivera DE, Ocampo YC, Castro JP, Barrios L, Diaz F and Franco LA: A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces. Saudi J Biol Sci. 26:1758–1766. 2019.PubMed/NCBI View Article : Google Scholar

10 

Chouhan S and Guleria S: Anti-inflammatory activity of medicinal plants: Present status and future perspectives. In: Singh B (ed) Botanical Leads for Drug Discovery. Springer Singapore, pp67-92, 2020.

11 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

12 

Nebbia M, Yassin NA and Spinelli A: Colorectal cancer in inflammatory bowel disease. Clin Colon Rectal Surg. 33:305–317. 2020.PubMed/NCBI View Article : Google Scholar

13 

Makin G: Principles of chemotherapy. Paediatr Child Heal. 28:183–188. 2018.

14 

Safarzadeh E, Shotorbani SS and Baradaran B: Herbal medicine as inducers of apoptosis in cancer treatment. Adv Pharm Bull. 4 (Suppl 1):S421–S427. 2014.PubMed/NCBI View Article : Google Scholar

15 

Franken NAP, Rodermond HM, Stap J, Haveman J and van Bree C: Clonogenic assay of cells in vitro. Nat Protoc. 1:2315–2319. 2006.PubMed/NCBI View Article : Google Scholar

16 

Yang X: Clonogenic assay to test cancer therapies. Bio Protocol. 2:1–3. 2012.

17 

HT-29 | ATCC. Atcc.org, 2020. Available from: https://www.atcc.org/products/htb-38#detailed-product-information.

18 

Weisser H, Göbel T, Melissa Krishnathas G, Kreiß M, Angioni C, Sürün D, Thomas D, Schmid T, Häfner AK and Kahnt AS: Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function. Cancer Gene Ther. 30:108–123. 2023.PubMed/NCBI View Article : Google Scholar

19 

Neufert C, Becker C and Neurath MF: An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc. 2:1998–2004. 2007.PubMed/NCBI View Article : Google Scholar

20 

Deng J, Zhao L, Yuan X, Li Y, Shi J, Zhang H, Zhao Y, Han L, Wang H, Yan Y, et al: Pre-administration of berberine exerts chemopreventive effects in AOM/DSS-induced colitis-associated carcinogenesis mice via modulating inflammation and intestinal microbiota. Nutrients. 14(726)2022.PubMed/NCBI View Article : Google Scholar

21 

Obermeier F, Kojouharoff G, Hans W, Schölmerich J, Gross V and Falk W: Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice. Clin Exp Immunol. 116:238–245. 1999.PubMed/NCBI View Article : Google Scholar

22 

Kimlin LC, Casagrande G and Virador VM: In vitro three-dimensional (3D) models in cancer research: An update. Mol Carcinog. 52:167–182. 2013.PubMed/NCBI View Article : Google Scholar

23 

Atat O El, Farzaneh Z, Pourhamzeh M, Taki F, Abi-Habib R, Vosough M and El-Sibai M: 3D modeling in cancer studies. Hum Cell. 35:23–36. 2022.PubMed/NCBI View Article : Google Scholar

24 

Zibaei Z, Babaei E, Rezaie Nezhad Zamani A, Rahbarghazi R and Azeez HJ: Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro. Cancer Nanotechnol. 12(3)2021.

25 

Ballesteros-Vivas D, Alvarez-Rivera G, León C, Morantes SJ, Ibánez E, Parada-Alfonso F and Valdés A: Anti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by foodomics. J Funct Foods. 63(103567)2019.

26 

Ocampo YC, Caro DC, Rivera DE and Franco LA: Safety of sucrose esters from Physalis peruviana L. in a 28-day repeated-dose study in mice. Biomed Pharmacother. 90:850–862. 2017.PubMed/NCBI View Article : Google Scholar

27 

Zhang CR, Khan W, Bakht J and Nair MG: New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chem. 196:726–732. 2016.PubMed/NCBI View Article : Google Scholar

28 

Mora Vargas JA, Orduña Ortega J, Metzker G, Larrahondo JE and Boscolo M: Natural sucrose esters: Perspectives on the chemical and physiological use of an under investigated chemical class of compounds. Phytochemistry. 177(112433)2020.PubMed/NCBI View Article : Google Scholar

29 

Wang Y, Wang Z, Sun Y, Zhu M, Jiang Y, Bai H, Yang B and Kuang H: Isovaleryl sucrose esters from Atractylodes japonica and their cytotoxic activity. Molecules. 29(3069)2024.PubMed/NCBI View Article : Google Scholar

30 

Teng Y, Lan P, White LV and Banwell MG: The useful biological properties of sucrose esters: Opportunities for the development of new functional foods. Crit Rev Food Sci Nutr. 64:8018–8035. 2024.PubMed/NCBI View Article : Google Scholar

31 

Hatta MNA, Mohamad Hanif EAM, Chin SF, Low TY and Neoh HM: Parvimonas micra infection enhances proliferation, wound healing, and inflammation of a colorectal cancer cell line. Biosci Rep. 43(BSR20230609)2023.PubMed/NCBI View Article : Google Scholar

32 

Silva Nunes JP and Martins Dias AA: ImageJ macros for the user-friendly analysis of soft-agar and wound-healing assays. Biotechniques. 62:175–179. 2017.PubMed/NCBI View Article : Google Scholar

33 

Stark GR and Taylor WR: Analyzing the G2/M checkpoint. In: Checkpoint Controls and Cancer; Methods in Molecular Biology™. Vol. 280. Humana Press: Totowa, NJ, USA, pp51-82, 2004.

34 

Chinnasamy S, Zameer F and Muthuchelian K: Molecular and biological mechanisms of apoptosis and its detection techniques. J Oncol Sci. 6:49–64. 2020.

35 

Thaker AI, Shaker A, Suprada Rao M and Ciorba MA: Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp. 4100:2012.PubMed/NCBI View Article : Google Scholar

36 

De Robertis M and Signori E: Azoxymethane/dextran sodium sulfate (AOM/DSS) model of colorectal cancer. In: Čemažar M, Jesenko T and Lampreht Tratar U (eds) Mouse Models of Cancer. Methods in Molecular Biology. Vol. 2773. Humana, New York, NY, pp51-58, 2024.

37 

Chen X, Ding Y, Yi Y, Chen Z, Fu J and Chang Y: Review of animal models of colorectal cancer in different carcinogenesis pathways. Dig Dis Sci. 69:1583–1592. 2024.PubMed/NCBI View Article : Google Scholar

38 

Lin R, Piao M, Song Y and Liu C: Quercetin suppresses AOM/DSS-induced colon carcinogenesis through its anti-inflammation effects in mice. J Immunol. 2020(9242601)2020.PubMed/NCBI View Article : Google Scholar

39 

Lee YP, Chiu CC, Lin TJ, Hung SW, Huang WC, Chiu CF, Huang YT, Chen YH, Chen TH and Chuang HL: The germ-free mice monocolonization with Bacteroides fragilis improves azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer. Immunopharmacol Immunotoxicol. 41:207–213. 2019.PubMed/NCBI View Article : Google Scholar

40 

De Robertis M, Massi E, Poeta M, Carotti S, Morini S, Cecchetelli L, Signori E and Fazio VM: The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog. 10(9)2011.PubMed/NCBI View Article : Google Scholar

41 

Giner E, Recio MC, Ríos JL, Cerdá-Nicolás JM and Giner RM: Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. Mol Nutr Food Res. 60:242–255. 2016.PubMed/NCBI View Article : Google Scholar

42 

Takahashi M, Mutoh M, Kawamori T, Sugimura T and Wakabayashi K: Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. Carcinogenesis. 21:1319–1327. 2000.PubMed/NCBI

43 

Tang A, Li N, Li X, Yang H, Wang W, Zhang L, Li G, Xiong W, Ma J and Shen S: Dynamic activation of the key pathways: Linking colitis to colorectal cancer in a mouse model. Carcinogenesis. 33:1375–1383. 2012.PubMed/NCBI View Article : Google Scholar

44 

Ranganathan AC, Adam AP and Aguirre-Ghiso JA: Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle. 5:1799–1807. 2006.PubMed/NCBI View Article : Google Scholar

45 

Zhang L and Gu X: 4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling. Aging (Albany NY). 16:8142–8154. 2024.PubMed/NCBI View Article : Google Scholar

46 

KRAS gene-Genetics Home Reference-NIH, 2020 [cited 2020 Mar 9]. Available from: https://ghr.nlm.nih.gov/gene/KRAS.

47 

Vivona AA, Shpitz B, Medline A, Bruce WR, Hay K, Ward MA, Stern HS and Gallinger S: K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis. 14:1777–1781. 1993.PubMed/NCBI View Article : Google Scholar

48 

Bragado P, Armesilla A, Silva A and Porras A: Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis. 12:1733–1742. 2007.PubMed/NCBI View Article : Google Scholar

49 

Cheung KL, Khor TO, Yu S and Kong ANT: PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. AAPS J. 10:277–281. 2008.PubMed/NCBI View Article : Google Scholar

50 

Gupta J and Nebreda AR: Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer. FEBS J. 282:1841–1857. 2015.PubMed/NCBI View Article : Google Scholar

51 

Li W, Li C, Zheng H, Chen G and Hua B: Therapeutic targets of Traditional Chinese Medicine for colorectal cancer. J Tradit Chinese Med. 36:243–249. 2016.PubMed/NCBI View Article : Google Scholar

52 

Hu R, Kim BR, Chen C, Hebbar V and Kong ANT: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis. 24:1361–1367. 2003.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ocampo Y, Caro D, Rivera D, Castro J, Pájaro I, Salas R and Franco L: Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice. Biomed Rep 21: 188, 2024.
APA
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., & Franco, L. (2024). Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice. Biomedical Reports, 21, 188. https://doi.org/10.3892/br.2024.1876
MLA
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., Franco, L."Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice". Biomedical Reports 21.6 (2024): 188.
Chicago
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., Franco, L."Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice". Biomedical Reports 21, no. 6 (2024): 188. https://doi.org/10.3892/br.2024.1876
Copy and paste a formatted citation
x
Spandidos Publications style
Ocampo Y, Caro D, Rivera D, Castro J, Pájaro I, Salas R and Franco L: Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice. Biomed Rep 21: 188, 2024.
APA
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., & Franco, L. (2024). Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice. Biomedical Reports, 21, 188. https://doi.org/10.3892/br.2024.1876
MLA
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., Franco, L."Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice". Biomedical Reports 21.6 (2024): 188.
Chicago
Ocampo, Y., Caro, D., Rivera, D., Castro, J., Pájaro, I., Salas, R., Franco, L."Active fraction of ground cherry (<em>Physalis angulata</em> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice". Biomedical Reports 21, no. 6 (2024): 188. https://doi.org/10.3892/br.2024.1876
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