Effect of infusion time on risk of <em>Bacillus cereus</em> bloodstream infections in patients administered with BFLUID amino acid infusions via peripheral venous catheters

Takano,Atsushi; Nakamaru,Yuta; Sako,Ken-Ichi; Takano,Asuka; Iga,Masanori; Machida,Mitsuru; Kaku,Teppei; Ishimura,Atsushi; Nakasuga,Hirotaka; Matsuda,Yoshikazu; Fujikake,Yoshio; Maeda,Tomoji

doi:10.3892/br.2024.1895

February-2025 Volume 22 Issue 2

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February-2025 Volume 22 Issue 2

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Article Special Issue Open Access

Effect of infusion time on risk of Bacillus cereus bloodstream infections in patients administered with BFLUID amino acid infusions via peripheral venous catheters

This article is part of the special Issue: Advance in detection, diagnosis and treatment of infectious diseases

Authors:
- Atsushi Takano
- Yuta Nakamaru
- Ken-Ichi Sako
- Asuka Takano
- Masanori Iga
- Mitsuru Machida
- Teppei Kaku
- Atsushi Ishimura
- Hirotaka Nakasuga
- Yoshikazu Matsuda
- Yoshio Fujikake
- Tomoji Maeda
View Affiliations / Copyright

Affiliations: Department of Pharmacy, Saitama Red Cross Hospital, Saitama 330‑8553, Japan, Department of Clinical Pharmacy, Nihon Pharmaceutical University, Saitama 362‑0806, Japan

Copyright: © Takano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 17
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Published online on: November 21, 2024

https://doi.org/10.3892/br.2024.1895
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Abstract

Comprehensive electrolyte infusions containing amino acids, including BFLUID, are a source of nosocomial infections caused by Bacillus cereus. It is recommended that clinicians finish the administration of BFLUID within 6 h; however, this recommendation currently lacks supporting empirical evidence. Accordingly, the present study aimed to investigate the risk of B. cereus infection associated with BFLUID infusion according to the administration time. In the present single‑center retrospective observational cohort study, clinical information was extracted from the medical records of patients aged ≥18 years who received BFLUID infusions via a peripheral line between April 2017 and October 2020 at Saitama Red Cross Hospital (Saitama, Japan). A total of 96 patients were enrolled during the study period, of whom 32 developed B. cereus infection. No patients with BFLUID infusions administered within 6 h developed B. cereus infection. Compared with patients who received BFLUID infusions within 8 h, those who received BFLUID infusions after 8 h had a 7‑fold higher risk of infection. The present study provided empirical evidence supporting the recommendation that amino acid infusions should be administered to patients within 6 h to minimize the risk of B. cereus infection.

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1	Bottone EJ: Bacillus cereus, a volatile human pathogen. Clin Microbiol Rev. 23:382–398. 2010.PubMed/NCBI View Article : Google Scholar
2	Pearson HE: Human infections caused by organisms of the Bacillus species. Am J Clin Pathol. 53:506–515. 1970.PubMed/NCBI View Article : Google Scholar
3	Japan Nosocomial Infections Surveillance in 2022: Ministry of Health, Labour and Welfare, 2023. https://janis.mhlw.go.jp/report/open_report/2022/3/1/ken_Open_Report_202200.pdf.
4	Kusama Y, Honma I, Masuda M, Goto H and Onodera S: Bacillus cereus outbreak in normal neonates at our hospital. Kankyo kansen-shi [Environmental Infection Magazine]. 30:385–390. 2015.
5	Matsumoto S, Suenaga H, Naito K, Sawazaki M, Hiramatsu T and Agata N: Management of suspected nosocomial infection: an audit of 19 hospitalized patients with septicemia caused by Bacillus species. Jpn J Infect Dis. 53:196–202. 2000.PubMed/NCBI
6	Aso Y, Nagatomi M, Nakazawa T, Sasaki S and Ishi K: Examination of infusion fluid type and environmental factors involved in increased Bacillus cereus bloodstream infection. Jpn J Environ Infect. 27:81–90. 2012.
7	Nakamura K, Yarimizu A, Ihara T, Sawayama Y and Ishimaru T: An analysis of a case in which Bacillus cereus bacteremia developed from the use of carry-on towels which resulted in the horizontal transmission of this organism in the same ward. Kansenshogaku zasshi. 92:80–85. 2018.(In Japanese).
8	Hino C, Ozaki M, Kitahara T, Kouda K, Shikichi K, Nakamura I, Kawai S and Oie S: Peripheral parenteral nutrition solutions and bed bath towels as risk factors for nosocomial peripheral venous catheter-related bloodstream infection by bacillus cereus. Int J Med Sci. 20:566–571. 2023.PubMed/NCBI View Article : Google Scholar
9	Kutsuna S, Hayakawa K, Kita K, Katanami Y, Imakita N, Kasahara K, Seto M, Akazawa K, Shimizu M, Kano T, et al: Risk factors of catheter-related bloodstream infection caused by Bacillus cereus: Case-control study in 8 teaching hospitals in Japan. Am J Infect Control. 45:1281–1283. 2017.PubMed/NCBI View Article : Google Scholar
10	Sakihama T and Tokuda Y: Use of peripheral parenteral nutrition solutions as a risk factor for Bacillus cereus peripheral venous catheter-associated bloodstream infection at a Japanese tertiary care hospital: A case-control study. Jpn J Infect Dis. 69:531–533. 2016.PubMed/NCBI View Article : Google Scholar
11	Kuwahara T, Kaneda S, Shimono K and Inoue Y: Effects of lipid emulsion and multivitamins on the growth of microorganisms in peripheral parenteral nutrition solutions. Int J Med Sci. 10:1079–1084. 2013.PubMed/NCBI View Article : Google Scholar
12	Sasahara T, Hayashi S, Hosoda K, Inagawa H, Morisawa Y and Hirai Y: Bacterial growth in intravenous fluid products. In: Proceedings in the 11th East Asian Conference on Infection Control and Prevention (EACIC) [abstract], Tokyo, Japan. EACIC, p24 2012.
13	Kuroki R, Kawakami K, Qin L, Kaji C, Watanabe K, Kimura Y, Ishiguro C, Tanimura S, Tsuchiya Y, Hamaguchi I, et al: Nosocomial bacteremia caused by biofilm-forming Bacillus cereus and Bacillus thuringiensis. Intern Med. 48:791–796. 2009.PubMed/NCBI View Article : Google Scholar
14	Shiota A, Asai N, Koizumi Y, Watanabe H, Sakata M, Kurumiya A, Takahashi T, Muramatsu Y, Hagihara M, Suematsu H, et al: Extended drip infusion of peripheral parental nutrition containing amino acids might be associated with Bacillus cereus bloodstream infection. Am J Infect Control. 47:1154–1156. 2019.PubMed/NCBI View Article : Google Scholar
15	Sakai Y, Konishi T, Obayashi Y, Honda K, Akae S and Ishihara K: Study of growth level of Bacillus cereus in various infusion fluids. Shimane J Med Technol. 40:19–23. 2012.
16	Bonnett LJ, Snell KIE, Collins GS and Riley RD: Guide to presenting clinical prediction models for use in clinical settings. BMJ. 365(l737)2019.PubMed/NCBI View Article : Google Scholar
17	Shimoda M, Tanaka Y, Morimoto K, Yoshimori K and Ohta K: Risk factors for bloodstream infection in patients receiving peripheral parenteral nutrition. Intern Med 2024 (Epub ahead of print).
18	Minatoguchi S, Nomura A, Imaizumi T, Sasaki S, Ozeki T, Uchida D, Kawarazaki H, Sasai F, Tomita K, Shimizu H and Fujita Y: Low serum albumin as a risk factor for infection-related in-hospital death among hemodialysis patients hospitalized on suspicion of infectious disease: A Japanese multicenter retrospective cohort study. Ren Replace Ther. 4(30)2018.
19	Payne-James JJ and Khawaja HT: First choice for total parenteral nutrition: The peripheral route. JPEN J Parenter Enteral Nutr. 17:468–478. 1993.PubMed/NCBI View Article : Google Scholar