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Review Open Access

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)

  • Authors:
    • Timur Saliev
    • Prim B. Singh
  • View Affiliations / Copyright

    Affiliations: Institute of Basic and Applied Medical Research, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, Republic of Kazakhstan, School of Medicine, Nazarbayev University, Astana 010000, Republic of Kazakhstan
    Copyright: © Saliev et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
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    Published online on: April 10, 2025
       https://doi.org/10.3892/br.2025.1974
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Abstract

Age reprogramming and cellular rejuvenation therapies are revolutionizing the approach to aging and age‑related diseases. These ground‑breaking interventions target fundamental biological processes, including genomic instability, telomere attrition, and mitochondrial dysfunction, to restore cellular function and delay the onset of degenerative conditions. Emerging strategies such as epigenetic reprogramming, gene editing, stem cell therapy, and senolytic drugs show immense promise in extending health spans and potentially reversing aspects of aging. Despite marked progress in preclinical studies and early‑stage clinical trials, translating these therapies into practical healthcare solutions presents significant challenges. Key issues include ensuring safety, optimizing delivery mechanisms, overcoming regulatory barriers, and addressing high costs. Moreover, ethical and economic considerations, such as equitable access and societal impacts, must be carefully addressed to prevent widening health disparities. The present review examines the current state of cellular rejuvenation research, highlighting both scientific advancements and the complex challenges associated with these therapies. With interdisciplinary collaboration, robust ethical frameworks, and scalable technological innovations, these therapies have the potential to transform healthcare. By shifting the focus from disease management to proactive health preservation, they offer a future where aging becomes a manageable and equitable process.
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Copy and paste a formatted citation
Spandidos Publications style
Saliev T and Singh PB: Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review). Biomed Rep 22: 96, 2025.
APA
Saliev, T., & Singh, P.B. (2025). Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review). Biomedical Reports, 22, 96. https://doi.org/10.3892/br.2025.1974
MLA
Saliev, T., Singh, P. B."Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)". Biomedical Reports 22.6 (2025): 96.
Chicago
Saliev, T., Singh, P. B."Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)". Biomedical Reports 22, no. 6 (2025): 96. https://doi.org/10.3892/br.2025.1974
Copy and paste a formatted citation
x
Spandidos Publications style
Saliev T and Singh PB: Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review). Biomed Rep 22: 96, 2025.
APA
Saliev, T., & Singh, P.B. (2025). Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review). Biomedical Reports, 22, 96. https://doi.org/10.3892/br.2025.1974
MLA
Saliev, T., Singh, P. B."Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)". Biomedical Reports 22.6 (2025): 96.
Chicago
Saliev, T., Singh, P. B."Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)". Biomedical Reports 22, no. 6 (2025): 96. https://doi.org/10.3892/br.2025.1974
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