Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
June-2025 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A novel link between KCNQ1 genetic variants and polycystic ovary syndrome susceptibility

  • Authors:
    • Assila Ben Salem
    • Intissar Ezzidi
    • Hassen Ben Abdennebi
    • Nabil Mtiraoui
    • Sameh Sarray
  • View Affiliations / Copyright

    Affiliations: Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, Tunisia, College of Medicine and Health Sciences, Arabian Gulf University, 0329 Manama, Kingdom of Bahrain
    Copyright: © Ben Salem et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 104
    |
    Published online on: April 22, 2025
       https://doi.org/10.3892/br.2025.1982
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Genome‑wide association studies (GWAS) have identified the potassium voltage‑gated channel subfamily Q member 1 (KCNQ1) gene, as a potential contributor to the pathogenesis of type 2 diabetes (T2D). Given the known genetic overlap between T2D and polycystic ovary syndrome (PCOS), the present study aimed to investigate the potential association between KCNQ1 gene variants and PCOS susceptibility in a population of Tunisian women. A total of 230 patients and 230 healthy controls were recruited for this case control study. The Rotterdam consensus criteria were used to diagnose patients with PCOS. Genotyping of three KCNQ1 variants (rs231361, rs151290 and rs2237895), was performed using allelic discrimination (real-time PCR). After excluding false positive associations using the false discovery rate adjustment and ensuring statistical power >80%, the present results suggested that the KCNQ1 gene may play a role in PCOS susceptibility. Specifically, the rs231361 variant showed a significant association with an increased risk of PCOS through multiple genetic inheritance models. Additionally, the A/A genotype of the rs231361 variant displayed a correlation with increased levels of triglycerides compared with those with the G/G wild‑type and the G/A heterozygous genotypes. To the best of our knowledge, this is the first study to identify the KCNQ1 rs231361 variant as a potential genetic risk factor for PCOS. These findings have important implications for risk assessment and the development of personalized treatment approaches for affected women.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Escobar-Morreale HF: Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 14:270–284. 2018.PubMed/NCBI View Article : Google Scholar

2 

Deswal R, Narwal V, Dang A and Pundir CS: The prevalence of polycystic ovary syndrome: A brief systematic review. J Hum Reprod Sci. 13:261–271. 2020.PubMed/NCBI View Article : Google Scholar

3 

Li M, Ruan X and Mueck AO: Management strategy of infertility in polycystic ovary syndrome. Glob Health J. 6:70–74. 2022.

4 

Goodarzi MO, Dumesic DA, Chazenbalk G and Azziz R: Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 7:219–231. 2011.PubMed/NCBI View Article : Google Scholar

5 

Costello M, Garad R, Hart R, Homer H, Johnson L, Jordan C, Mocanu E, Qiao J, Rombauts L, Teede HJ, et al: A review of first line infertility treatments and supporting evidence in women with polycystic ovary syndrome. Med Sci (Basel). 7(95)2019.PubMed/NCBI View Article : Google Scholar

6 

Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F and Kumar M: Polycystic ovary syndrome: Etiology, current management, and future therapeutics. J Clin Med. 12(1454)2023.PubMed/NCBI View Article : Google Scholar

7 

Bordewijk EM, Ng KYB, Rakic L, Mol BWJ, Brown J, Crawford TJ and van Wely M: Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev. 2(CD001122)2020.PubMed/NCBI View Article : Google Scholar

8 

Dong J and Rees DA: Polycystic ovary syndrome: Pathophysiology and therapeutic opportunities. BMJ Med. 2(e000548)2023.PubMed/NCBI View Article : Google Scholar

9 

Barry JA, Azizia MM and Hardiman PJ: Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: A systematic review and meta-analysis. Hum Reprod Update. 20:748–758. 2014.PubMed/NCBI View Article : Google Scholar

10 

Chen Q, Zheng B, Du S and Lin Y: Explore the potential molecular mechanism of polycystic ovarian syndrome by protein-protein interaction network analysis. Taiwan J Obstet Gynecol. 60:807–815. 2021.PubMed/NCBI View Article : Google Scholar

11 

Hong SH, Hong YS, Jeong K, Chung H, Lee H and Sung YA: Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes. Sci Rep. 10(10479)2020.PubMed/NCBI View Article : Google Scholar

12 

Dixit G, Dabney-Smith C and Lorigan GA: The membrane protein KCNQ1 potassium ion channel: Functional diversity and current structural insights. Biochim Biophys Acta Biomembr. 1862(183148)2020.PubMed/NCBI View Article : Google Scholar

13 

Kuenze G, Duran AM, Woods H, Brewer KR, McDonald EF, Vanoye CG, George AL Jr, Sanders CR and Meiler J: Upgraded molecular models of the human KCNQ1 potassium channel. PLoS One. 14(e0220415)2019.PubMed/NCBI View Article : Google Scholar

14 

Jespersen T, Grunnet M and Olesen SP: The KCNQ1 potassium channel: From gene to physiological function. Physiology (Bethesda). 20:408–416. 2005.PubMed/NCBI View Article : Google Scholar

15 

Gao T, Li K, Liang F, Yu J, Liu A, Ni Y and Sun P: KCNQ1 potassium channel expressed in human sperm is involved in sperm motility, acrosome reaction, protein tyrosine phosphorylation, and ion homeostasis during capacitation. Front Physiol. 12(761910)2021.PubMed/NCBI View Article : Google Scholar

16 

Grahammer F, Herling AW, Lang HJ, Schmitt-Gräff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J and Warth R: The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology. 120:1363–1371. 2001.PubMed/NCBI View Article : Google Scholar

17 

Neyroud N, Richard P, Vignier N, Donger C, Denjoy I, Demay L, Shkolnikova M, Pesce R, Chevalier P, Hainque B, et al: Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome. Circ Res. 84:290–297. 1999.PubMed/NCBI View Article : Google Scholar

18 

Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C, Barhanin J, Fauré S, Gary F, Coumel P, Petit C, et al: A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet. 15:186–189. 1997.PubMed/NCBI View Article : Google Scholar

19 

Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, et al: Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes. 61:1726–1733. 2012.PubMed/NCBI View Article : Google Scholar

20 

Tiron C, Campuzano O, Pérez-Serra A, Mademont I, Coll M, Allegue C, Iglesias A, Partemi S, Striano P, Oliva A and Brugada R: Further evidence of the association between LQT syndrome and epilepsy in a family with KCNQ1 pathogenic variant. Seizure. 25:65–67. 2015.PubMed/NCBI View Article : Google Scholar

21 

Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL and Noebels JL: Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 1(2ra6)2009.PubMed/NCBI View Article : Google Scholar

22 

Lieve KVV and Wilde AAM: Inherited ion channel diseases: A brief review. Europace. 17 (Suppl 2):ii1–ii6. 2015.PubMed/NCBI View Article : Google Scholar

23 

Morris AP: Fine mapping of type 2 diabetes susceptibility loci. Curr Diab Rep. 14(549)2014.PubMed/NCBI View Article : Google Scholar

24 

Ma Q, Wang L, Yao H, Wang TT, Ma Y, Su YX, Wang ZQ, Zhu J, Wang SX, Zhang ZX, et al: Association between KCNQ1 genetic variants and type 2 diabetes in the uyghur population. Genet Test Mol Biomarkers. 19:698–702. 2015.PubMed/NCBI View Article : Google Scholar

25 

Been LF, Ralhan S, Wander GS, Mehra NK, Singh J, Mulvihill JJ, Aston CE and Sanghera DK: Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC Med Genet. 12(18)2011.PubMed/NCBI View Article : Google Scholar

26 

Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jørgensen T, et al: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet. 40:1098–1102. 2008.PubMed/NCBI View Article : Google Scholar

27 

Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, et al: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet. 40:1092–1097. 2008.PubMed/NCBI View Article : Google Scholar

28 

Sun Q, Song K, Shen X and Cai Y: The association between KCNQ1 gene polymorphism and type 2 diabetes risk: A meta-analysis. PLoS One. 7(e48578)2012.PubMed/NCBI View Article : Google Scholar

29 

Thong EP, Codner E, Laven JSE and Teede H: Diabetes: A metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol. 8:134–149. 2020.PubMed/NCBI View Article : Google Scholar

30 

Glintborg D, Ollila MM, Møller JK, Pesonen P, Persson S, Elenis E, Rubin KH, Gissler M, Andersen MS, Sundström-Poromaa I and Piltonen T: Prospective risk of type 2 diabetes in 99 892 Nordic women with polycystic ovary syndrome and 446 055 controls: National cohort study from Denmark, Finland, and Sweden. Hum Reprod. 39:1823–1834. 2024.PubMed/NCBI View Article : Google Scholar

31 

Hossain MA, Al Ashik SA, Mahin MR, Al Amin M, Rahman MH, Khan MA and Emran AA: Systems biology and in silico-based analysis of PCOS revealed the risk of metabolic disorders. Heliyon. 8(e12480)2022.PubMed/NCBI View Article : Google Scholar

32 

Márquez JL, Pacheco A, Valdés P and Salazar LA: Association between CAPN10 UCSNP-43 gene polymorphism and polycystic ovary syndrome in Chilean women. Clin Chim Acta. 398:5–9. 2008.PubMed/NCBI View Article : Google Scholar

33 

Gonzalez A, Abril E, Roca A, Aragón MJ, Figueroa MJ, Velarde P, Royo JL, Real LM and Ruiz A: Comment: CAPN10 alleles are associated with polycystic ovary syndrome. J Clin Endocrinol Metab. 87:3971–3976. 2002.PubMed/NCBI View Article : Google Scholar

34 

Tang ST, Wang CJ, Tang HQ, Peng WJ, Wang YM and Zhang Q: Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: A meta-analysis. Mol Biol Rep. 39:9649–9660. 2012.PubMed/NCBI View Article : Google Scholar

35 

Xu X, Zhao H, Shi Y, You L, Bian Y, Zhao Y and Chen ZJ: Family association study between INSR gene polymorphisms and PCOS in Han Chinese. Reprod Biol Endocrinol. 9(76)2011.PubMed/NCBI View Article : Google Scholar

36 

Christopoulos P, Mastorakos G, Gazouli M, Panidis D, Deligeoroglou E, Katsikis I, Papadias K, Diamandi-Kandarakis E and Creatsas G: Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome. Gynecol Endocrinol. 24:486–490. 2008.PubMed/NCBI View Article : Google Scholar

37 

Wojciechowski P, Lipowska A, Rys P, Ewens KG, Franks S, Tan S, Lerchbaum E, Vcelak J, Attaoua R, Straczkowski M, et al: Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: A systematic review and meta-analysis. Diabetologia. 55:2636–2645. 2012.PubMed/NCBI View Article : Google Scholar

38 

Waterworth DM, Bennett ST, Gharani N, McCarthy MI, Hague S, Batty S, Conway GS, White D, Todd JA, Franks S and Williamson R: Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet. 349:986–990. 1997.PubMed/NCBI View Article : Google Scholar

39 

Li X, Xiao H, Ma Y, Zhou Z and Chen D: Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes. Front Genet. 13(905716)2022.PubMed/NCBI View Article : Google Scholar

40 

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 19:41–47. 2004.PubMed/NCBI View Article : Google Scholar

41 

Christ JP and Cedars MI: Current guidelines for diagnosing PCOS. Diagnostics (Basel). 13(1113)2023.PubMed/NCBI View Article : Google Scholar

42 

General Assembly of the World Medical Association. World medical association declaration of Helsinki: Ethical principles for medical research involving human subjects. J Am Coll Dent. 81:14–18. 2014.PubMed/NCBI

43 

Mousa M, Al-Jefout M, Alsafar H, Kirtley S, Lindgren CM, Missmer SA, Becker CM, Zondervan KT and Rahmioglu N: Prevalence of common gynecological conditions in the middle east: Systematic review and meta-analysis. Front Reprod Health. 3(661360)2021.PubMed/NCBI View Article : Google Scholar

44 

Leem S and Park T: An empirical fuzzy multifactor dimensionality reduction method for detecting gene-gene interactions. BMC Genomics. 18 (Suppl 2)(S115)2017.PubMed/NCBI View Article : Google Scholar

45 

Turki A, Mtiraoui N, Al-Busaidi AS, Khirallah M, Mahjoub T and Almawi WY: Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs. Diabetes Res Clin Pract. 98:452–458. 2012.PubMed/NCBI View Article : Google Scholar

46 

Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen TS, Pisinger C, Borch-Johnsen K, Sandbaek A, Lauritzen T, Brunak S, et al: The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. PLoS One. 4(e5872)2009.PubMed/NCBI View Article : Google Scholar

47 

Chen Z, Yin Q, Ma G and Qian Q: KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population. Cardiovasc Diabetol. 9(35)2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ben Salem A, Ezzidi I, Ben Abdennebi H, Mtiraoui N and Sarray S: A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility. Biomed Rep 22: 104, 2025.
APA
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., & Sarray, S. (2025). A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility. Biomedical Reports, 22, 104. https://doi.org/10.3892/br.2025.1982
MLA
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., Sarray, S."A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility". Biomedical Reports 22.6 (2025): 104.
Chicago
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., Sarray, S."A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility". Biomedical Reports 22, no. 6 (2025): 104. https://doi.org/10.3892/br.2025.1982
Copy and paste a formatted citation
x
Spandidos Publications style
Ben Salem A, Ezzidi I, Ben Abdennebi H, Mtiraoui N and Sarray S: A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility. Biomed Rep 22: 104, 2025.
APA
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., & Sarray, S. (2025). A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility. Biomedical Reports, 22, 104. https://doi.org/10.3892/br.2025.1982
MLA
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., Sarray, S."A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility". Biomedical Reports 22.6 (2025): 104.
Chicago
Ben Salem, A., Ezzidi, I., Ben Abdennebi, H., Mtiraoui, N., Sarray, S."A novel link between <em>KCNQ1</em> genetic variants and polycystic ovary syndrome susceptibility". Biomedical Reports 22, no. 6 (2025): 104. https://doi.org/10.3892/br.2025.1982
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team