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Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility

  • Authors:
    • Patrik Palacka
    • Elena Marusakova
    • Katarina Rejlekova
    • Alena Svobodova
    • Lucia Skokanova
    • Martina Vulganova
    • Jana Obertova
  • View Affiliations / Copyright

    Affiliations: 2nd Department of Oncology, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovakia, Department of Research and Development, Central‑European Biotech Institute, 040 11 Kosice, Slovakia, Department of Outpatient Chemotherapy, National Cancer Institute, 833 10 Bratislava, Slovakia
    Copyright: © Palacka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 120
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    Published online on: May 20, 2025
       https://doi.org/10.3892/br.2025.1998
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Abstract

BNT162b2 is a mRNA vaccine, approved by the US Food and Drug Administration and the European Medicines Agency that was designed to target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‑CoV‑2), the causative agent of Coronavirus disease 2019 (COVID‑19). Despite its widespread use, predictors of humoral immune responses after BNT162b2 administration remain uncertain. Consequently, a case‑control study was conducted involving 273 employees at the National Cancer Institute (Bratislava, Slovakia) for the present study. Specifically, the present study aimed to determine the incidence of symptomatic COVID‑19. In addition, the association between the safety of the third‑dose BNT162b2 and sex and body mass index (BMI) was assessed. The present study also explored the potential determinants of plasma IgG antibody levels following vaccination. In total, 294 participants were recruited and 273 met the inclusion criteria. At a median follow‑up of 4.7 months, 38 participants had symptomatic SARS‑CoV‑2 infection after vaccination. The incidence of adverse events (AEs) was found to be significantly higher in female patients compared with that in male patients. Furthermore, patients with a high BMI (≥30 kg/m²) had higher number of AEs compared with those with low BMI (P<0.05). IgG levels were observed to be significantly higher in male patients compared with those in female patients, in participants with high BMI compared with those with low BMI, in those experiencing three or more AEs compared with those with fewer AEs and in participants who had contracted COVID‑19 compared with those who had not (P<0.05 for all). Multivariate analysis identified sex, BMI, number of AEs and prior COVID‑19 infection as independent predictors of IgG plasma level (P<0.05). Therefore, the present study found the low number of COVID‑19 in the subjects vaccinated with the third dose of BNT162b2 and revealed that the safety profile of the vaccine is associated with sex and BMI. Higher IgG levels, indicating more efficient protection against SARS‑CoV‑2, were observed in male patients, in participants with high BMI, those experiencing a higher frequency of AEs and those who had previously contracted COVID‑19 despite vaccination against SARS‑CoV‑2. These findings could lead to the stratification of subjects within future clinical studies and the development of specific vaccination protocols in regard to sex, BMI and history of SARS‑CoV‑2.
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1 

World Health Organization: COVID-19: Vulnerable and high-risk groups.

2 

CDC. Underlying conditions and the higher risk for severe COVID-19.

3 

Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, et al: Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 383:2603–2615. 2020.PubMed/NCBI View Article : Google Scholar

4 

Thomas SJ, Moreira ED Jr, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Polack FP, Zerbini C, et al: Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine through 6 months. N Engl J Med. 385:1761–1773. 2021.PubMed/NCBI View Article : Google Scholar

5 

Moreira ED Jr, Kitchin N, Xu X, Dychter SS, Lockhart S, Gurtman A, Perez JL, Zerbini C, Dever ME, Jennings TW, et al: Safety and efficacy of a third dose of BNT162b2 Covid-19 vaccine. N Engl J Med. 386:1910–1921. 2022.PubMed/NCBI View Article : Google Scholar

6 

Aktaş G: A comprehensive review on rational and effective treatment strategies against an invisible enemy; SARS Cov-2 infection. Exp Biomed Res. 3:293–311. 2020.

7 

Wu Z and McGoogan JM: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 323:1239–1242. 2020.PubMed/NCBI View Article : Google Scholar

8 

Aktas G, Balci B, Yilmaz S, Bardak H, Duman TT and Civil C: Characteristics of Covid-19 infection with the original SARS-Cov-2 virus and other variants: A comparative review. J Bionic Mem. 2:96–112. 2022.

9 

Aktas G: Hematological predictors of novel coronavirus infection. Rev Assoc Med Bras (1992). 67 (Suppl 1):S1–S2. 2021.PubMed/NCBI View Article : Google Scholar

10 

Atak BM, Kahveci G, Bilgin S, Kurtkulagi O, Taslamacioglu Duman T, Demirkol ME and Aktas G: Haemoglobin and red cell distribution width levels in internal medicine patients indicate recurrent hospital admission during COVID-19. Fam Med Prim Care Rev. 24:32–36. 2022.

11 

Atak BM, Bilgin S, Kurtkulagi O, Kahveci G, Taslamacioglu Duman T, Sagdic T and Aktas G: Frailty in diabetic subjects during Covid-19 and its association with HbA1c, mean platelet volume and monocyte/lymphocyte ratio. Clin Diabetol. 11:119–126. 2022.

12 

Ostrowski SR, Søgaard OS, Tolstrup M, Stærke NB, Lundgren J, Østergaard L and Hvas AM: Inflammation and platelet activation after COVID-19 vaccines-possible mechanisms behind vaccine-induced immune thrombocytopenia and thrombosis. Front Immunol. 12(779453)2021.PubMed/NCBI View Article : Google Scholar

13 

Kumar G, Adams A, Hererra M, Rojas ER, Singh V, Sakhuja A, Meersman M, Dalton D, Kethireddy S, Nanchal R and Guddati AK: Predictors and outcomes of healthcare-associated infections in COVID-19 patients. Int J Infect Dis. 104:287–292. 2021.PubMed/NCBI View Article : Google Scholar

14 

Pilishvili T, Gierke R, Fleming-Dutra KE, Farrar JL, Mohr NM, Talan DA, Krishnadasan A, Harland KK, Smithline HA, Hou PC, et al: Effectiveness of mRNA Covid-19 vaccine among U.S. health care personnel. N Engl J Med. 385(e90)2021.PubMed/NCBI View Article : Google Scholar

15 

Benenson S, Oster Y, Cohen MJ and Nir-Paz R: BNT162b2 mRNA Covid-19 vaccine effectiveness among health care workers. N Engl J Med. 384:1775–1777. 2021.PubMed/NCBI View Article : Google Scholar

16 

Paris C, Perrin S, Hamonic S, Bourget B, Roué C, Brassard O, Tadié E, Gicquel V, Bénézit F, Thibault V, et al: Effectiveness of mRNA-BNT162b2, mRNA-1273, and ChAdOx1 nCoV-19 vaccines against COVID-19 in healthcare workers: An observational study using surveillance data. Clin Microbiol Infect. 27:1699.e5–e8. 2021.PubMed/NCBI View Article : Google Scholar

17 

Hall VJ, Foulkes S, Saei A, Andrews N, Oguti B, Charlett A, Wellington E, Stowe J, Gillson N, Atti A, et al: COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): A prospective, multicentre, cohort study. Lancet. 397:1725–1735. 2021.PubMed/NCBI View Article : Google Scholar

18 

Feikin DR, Higdon MM, Abu-Raddad LJ, Andrews N, Araos R, Goldberg Y, Groome MJ, Huppert A, O'Brien KL, Smith PG, et al: Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: Results of a systematic review and meta-regression. Lancet. 399:924–944. 2022.PubMed/NCBI View Article : Google Scholar

19 

Bobrovitz N, Ware H, Ma X, Li Z, Hosseini R, Cao C, Selemon A, Whelan M, Premji Z, Issa H, et al: Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: A systematic review and meta-regression. Lancet Infect Dis. 23:556–567. 2023.PubMed/NCBI View Article : Google Scholar

20 

Levin EG, Lustig Y, Cohen C, Fluss R, Indenbaum V, Amit S, Doolman R, Asraf K, Mendelson E, Ziv A, et al: Waning immune humoral response to BNT162b2 Covid-19 vaccine over 6 months. N Engl J Med. 385(e84)2021.PubMed/NCBI View Article : Google Scholar

21 

Palacka P, Pol'anová M, Svobodová A, Žigmond J, Zanchetta K, Gombárová V, Vulganová M, Slopovský J, Obertová J, Drgoňa Ľ, et al: Effectiveness, adverse events, and immune response following double vaccination with BNT162b2 in staff at the national comprehensive cancer center (NCCC). Vaccines (Basel). 10(558)2022.PubMed/NCBI View Article : Google Scholar

22 

Siemens Healthineers: SARS-CoV-2 IgG (sCOVG) assay for the detection of IgG antibodies to SARS-CoV-2. https://www.fda.gov/media/146931/download. Accessed August 26, 2023.

23 

National Council for the Social Studies (NCSS): NCSS Statistical Software. NCSS, LLC, Kaysville, UT, 2024. https://www.ncss.com/.

24 

Thompson CG, Kim RS, Aloe AM and Becker BJ: Extracting the variance inflation factor and other multicollinearity diagnostics from typical regression results. Basic Appl Soc Psychol. 39:81–90. 2017.

25 

Monitorovacia správa cirkulujúcich variantov vírusu SARS-CoV-2 v Slovenskej republike zachytených v systéme NarCoS-Národné Covid-19 Sekvenovanie.

26 

Kiss Z, Wittmann I, Polivka L, Surján G, Surján O, Barcza Z, Molnár GA, Nagy D, Müller V, Bogos K, et al: Nationwide effectiveness of first and second SARS-CoV2 booster vaccines during the delta and omicron pandemic waves in Hungary (HUN-VE 2 study). Front Immunol. 13(905585)2022.PubMed/NCBI View Article : Google Scholar

27 

Szekanecz Z, Vokó Z, Surján O, Rákóczi É, Szamosi S, Szűcs G, Szekanecz É, Müller C and Kiss Z: Effectiveness and waning of protection with the BNT162b2 vaccine against the SARS-CoV-2 delta variant in immunocompromised individuals. Front Immunol. 14(1247129)2023.PubMed/NCBI View Article : Google Scholar

28 

Berec L, Šmíd M, Přibylová L, Májek O, Pavlík T, Jarkovský J, Zajíček M, Weiner J, Barusová T and Trnka J: Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. PLoS One. 17(e0270801)2022.PubMed/NCBI View Article : Google Scholar

29 

Oster Y, Benenson S, Nir-Paz R, Buda I and Cohen MJ: The effect of a third BNT162b2 vaccine on breakthrough infections in health care workers: A cohort analysis. Clin Microbiol Infect. 28:735.e1–e3. 2022.PubMed/NCBI View Article : Google Scholar

30 

Klein SL and Flanagan KL: Sex differences in immune responses. Nat Rev Immunol. 16:626–638. 2016.PubMed/NCBI View Article : Google Scholar

31 

Tadount F, Doyon-Plourde P, Rafferty E, MacDonald S, Sadarangani M and Quach C: Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females?-A systematic review. Vaccine. 38:444–459. 2020.PubMed/NCBI View Article : Google Scholar

32 

Green MS, Peer V, Magid A, Hagani N, Anis E and Nitzan D: Gender differences in adverse events following the Pfizer-BioNTech COVID-19 vaccine. Vaccines (Basel). 10(233)2022.PubMed/NCBI View Article : Google Scholar

33 

Wei J, Stoesser N, Matthews PC, Ayoubkhani D, Studley R, Bell I, Bell JI, Newton JN, Farrar J, Diamond I, et al: Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom. Nat Microbiol. 6:1140–1149. 2021.PubMed/NCBI View Article : Google Scholar

34 

Amodio E, Capra G, Casuccio A, De Grazia S, Genovese D, Pizzo S, Calamusa G, Ferraro D, Giammanco GM, Vitale F and Bonura F: Antibodies responses to SARS-CoV-2 in a large cohort of vaccinated subjects and seropositive patients. Vaccines (Basel). 9(714)2021.PubMed/NCBI View Article : Google Scholar

35 

Đaković Rode O, Bodulić K, Zember S, Cetinić Balent N, Novokmet A, Čulo M, Rašić Ž, Mikulić R and Markotić A: Decline of anti-SARS-CoV-2 IgG antibody levels 6 months after complete BNT162b2 vaccination in healthcare workers to levels observed following the first vaccine dose. Vaccines (Basel). 10(153)2022.PubMed/NCBI View Article : Google Scholar

36 

Papaioannidou P, Skoumpa K, Bostanitis C, Michailidou M, Stergiopoulou T, Bostanitis I and Tsalidou M: Age, sex and BMI relations with anti-SARS-CoV-2-Spike IgG antibodies after BNT162b2 COVID-19 vaccine in health care workers in Northern Greece. Microorganisms. 11(1279)2023.PubMed/NCBI View Article : Google Scholar

37 

Braun E, Horowitz NA, Leiba R, Weissman A, Mekel M, Shachor-Meyouhas Y, Hussein K, Halberthal M, Azzam ZS and Berger G: Association between IgG antibody levels and adverse events after first and second Bnt162b2 mRNA vaccine doses. Clin Microbiol Infect. 28:1644–1648. 2022.PubMed/NCBI View Article : Google Scholar

38 

Ailsworth SM, Keshavarz B, Richards NE, Workman LJ, Murphy DD, Nelson MR, Platts-Mills TAE and Wilson JM: Enhanced SARS-CoV-2 IgG durability following COVID-19 mRNA booster vaccination and comparison of BNT162b2 with mRNA-1273. Ann Allergy Asthma Immunol. 130:67–73. 2023.PubMed/NCBI View Article : Google Scholar

39 

Wolszczak-Biedrzycka B, Bieńkowska A and Dorf J: Assessment of post-vaccination antibody response eight months after the administration of BNT1622b2 vaccine to healthcare workers with particular emphasis on the impact of previous COVID-19 infection. Vaccines (Basel). 9(1508)2021.PubMed/NCBI View Article : Google Scholar

40 

Wolszczak-Biedrzycka B, Bieńkowska A, Zaborowska JE, Smolińska-Fijołek E, Biedrzycki G and Dorf J: Anti-SARS-CoV-2S antibody levels in healthcare workers 10 months after the administration of two BNT162b2 vaccine doses in view of demographic characteristic and previous COVID-19 infection. Vaccines (Basel). 10(741)2022.PubMed/NCBI View Article : Google Scholar

41 

Wolszczak Biedrzycka B, Bieńkowska A, Smolińska-Fijołek E, Biedrzycki G and Dorf J: The influence of two priming doses of different anti-COVID-19 vaccines on the production of anti-SARS-CoV-2 antibodies after the administration of the Pfizer/BioNTech booster. Infect Drug Resist. 15:7811–7821. 2022.PubMed/NCBI View Article : Google Scholar

42 

Wolszczak-Biedrzycka B, Bieńkowska A, Cieślikiewicz B, Smolińska-Fijołek E, Biedrzycki G and Dorf J: The effect of the third dose of the BNT162b2 vaccine on anti-SARS-CoV-2 spike antibody levels in healthcare workers with and without COVID-19 infection. Ann Med. 55:722–732. 2023.PubMed/NCBI View Article : Google Scholar

43 

Sumbalova Z, Kucharska J, Palacka P, Rausova Z, Langsjoen PH, Langsjoen AM and Gvozdjakova A: Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19. Bratisl Lek Listy. 123:9–15. 2022.PubMed/NCBI View Article : Google Scholar

44 

Gvozdjáková A, Kucharská J, Rausová Z, Lopéz-Lluch G, Navas P, Palacka P, Bartolčičová B and Sumbalová Z: Effect of vaccination on platelet mitochondrial bioenergy function of patients with post-acute COVID-19. Viruses. 15(1085)2023.PubMed/NCBI View Article : Google Scholar

45 

Notarte KI, Ver AT, Velasco JV, Pastrana A, Catahay JA, Salvagno GL, Yap EPH, Martinez-Sobrido L, B Torrelles J, Lippi G and Henry BM: Effects of age, sex, serostatus, and underlying comorbidities on humoral response post-SARS-CoV-2 Pfizer-BioNTech mRNA vaccination: A systematic review. Crit Rev Clin Lab Sci. 59:373–390. 2022.PubMed/NCBI View Article : Google Scholar

46 

Francisco V, Pino J, Campos-Cabaleiro V, Ruiz-Fernández C, Mera A, Gonzalez-Gay MA, Gómez R and Gualillo O: Obesity, fat mass and immune system: Role for leptin. Front Physiol. 9(640)2018.PubMed/NCBI View Article : Google Scholar

47 

Petrone D, Mateo-Urdiales A, Sacco C, Riccardo F, Bella A, Ambrosio L, Lo Presti A, Di Martino A, Ceccarelli E, Del Manso M, et al: Reduction of the risk of severe COVID-19 due to omicron compared to delta variant in Italy (November 2021-February 2022). Int J Infect Dis. 129:135–141. 2023.PubMed/NCBI View Article : Google Scholar

48 

Sarker R, Roknuzzaman ASM, Nazmunnahar Hossain MJ and Islam MR: Benefits and probable ill effects of WHO's declaration of end of COVID-19 pandemic: A way back to pandemic-free normal life. Ann Med Surg (Lond). 85:3199–3201. 2023.PubMed/NCBI View Article : Google Scholar

49 

Roknuzzaman A, Sarker R, Nazmunnahar Shahriar M, Mosharrafa RA and Islam MR: The WHO has declared COVID-19 is no longer a pandemic-level threat: A perspective evaluating potential public health impacts. Clin Pathol. 17(2632010X241228053)2024.PubMed/NCBI View Article : Google Scholar

50 

Koolaparambil Mukesh R, Yinda CK, Munster VJ and van Doremalen N: Beyond COVID-19: The promise of next-generation coronavirus vaccines. NPJ Viruses. 2(39)2024.PubMed/NCBI View Article : Google Scholar

51 

Singh C, Verma S, Reddy P, Diamond MS, Curiel DT, Patel C, Jain MK, Redkar SV, Bhate AS, Gundappa V, et al: Phase III pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®). NPJ Vaccines. 8(125)2023.PubMed/NCBI View Article : Google Scholar

52 

Vishwanath S, Carnell GW, Ferrari M, Asbach B, Billmeier M, George C, Sans MS, Nadesalingam A, Huang CQ, Paloniemi M, et al: A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses. Nat Biomed Eng. 9:153–166. 2025.PubMed/NCBI View Article : Google Scholar

53 

Carreño JM, Raskin A, Singh G, Tcheou J, Kawabata H, Gleason C, Srivastava K, Vigdorovich V, Dambrauskas N, Gupta SL, et al: An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination. Sci Transl Med. 15(eabo2847)2023.PubMed/NCBI View Article : Google Scholar

54 

Xu K, Lei W, Kang B, Yang H, Wang Y, Lu Y, Lv L, Sun Y, Zhang J, Wang X, et al: A novel mRNA vaccine, SYS6006, against SARS-CoV-2. Front Immunol. 13(1051576)2023.PubMed/NCBI View Article : Google Scholar

55 

Ao D, He X, Liu J and Xu L: Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period. Signal Transduct Target Ther. 8(466)2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Palacka P, Marusakova E, Rejlekova K, Svobodova A, Skokanova L, Vulganova M and Obertova J: Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility. Biomed Rep 23: 120, 2025.
APA
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., & Obertova, J. (2025). Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility. Biomedical Reports, 23, 120. https://doi.org/10.3892/br.2025.1998
MLA
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., Obertova, J."Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility". Biomedical Reports 23.1 (2025): 120.
Chicago
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., Obertova, J."Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility". Biomedical Reports 23, no. 1 (2025): 120. https://doi.org/10.3892/br.2025.1998
Copy and paste a formatted citation
x
Spandidos Publications style
Palacka P, Marusakova E, Rejlekova K, Svobodova A, Skokanova L, Vulganova M and Obertova J: Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility. Biomed Rep 23: 120, 2025.
APA
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., & Obertova, J. (2025). Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility. Biomedical Reports, 23, 120. https://doi.org/10.3892/br.2025.1998
MLA
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., Obertova, J."Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility". Biomedical Reports 23.1 (2025): 120.
Chicago
Palacka, P., Marusakova, E., Rejlekova, K., Svobodova, A., Skokanova, L., Vulganova, M., Obertova, J."Humoral immune response following the third dose of BNT162b2 received by employees at a Slovak cancer healthcare facility". Biomedical Reports 23, no. 1 (2025): 120. https://doi.org/10.3892/br.2025.1998
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