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Review Open Access

Role of Nigella sativa L. seed (black cumin) in preventing photoaging (Review)

  • Authors:
    • Annisa Evanti
    • Teresa Liliana Wargasetia
    • Julia Windi Gunadi
  • View Affiliations / Copyright

    Affiliations: Master Program in Skin Ageing and Aesthetic Medicine, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia
    Copyright: © Evanti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
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    Published online on: June 4, 2025
       https://doi.org/10.3892/br.2025.2009
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Abstract

Photoaging is a group of clinical and pathological manifestations caused by ultraviolet (UV) radiation, characterized by deep wrinkles, rough skin textures, dyspigmentation and disturbance of skin elasticity. UV radiation can cause skin damage due to reactive oxygen species (ROS) accumulation, which activates matrix metalloproteinase and increases collagen damage. One natural ingredient that has antioxidant properties by reducing ROS production is black cumin or Nigella sativa (N. sativa) seeds; this effect is attributed to key components such as thymoquinone, flavonoids, essential fatty acids and essential minerals. The present review aimed to describe the potential ingredients of N. sativa and its mechanism against photoaging. PubMed, ScienceDirect, Springer and Google Scholar databases were searched between 2014 and March 2024. The keywords were N. sativa, black seed, thymoquinone and photoaging. The search was limited to articles in Indonesian and English. Based on the critical appraisal, the eligibility of the included articles was evaluated; nine eligible articles were selected. The authors indicated that N. sativa and its active ingredient, thymoquinone, may have a role in preventing photoaging through various potential mechanisms, including its antioxidant and anti‑inflammatory properties. Some studies have compared the effects of various types (oral and topical) of N. sativa and thymoquinone with good outcomes. N. sativa and thymoquinone may prevent photoaging by neutralizing UV‑induced ROS accumulation. More studies are required to determine the exact mechanism of N. sativa and thymoquinone as an alternative therapy for photoaging.
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Copy and paste a formatted citation
Spandidos Publications style
Evanti A, Wargasetia TL and Gunadi JW: Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review). Biomed Rep 23: 131, 2025.
APA
Evanti, A., Wargasetia, T.L., & Gunadi, J.W. (2025). Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review). Biomedical Reports, 23, 131. https://doi.org/10.3892/br.2025.2009
MLA
Evanti, A., Wargasetia, T. L., Gunadi, J. W."Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review)". Biomedical Reports 23.2 (2025): 131.
Chicago
Evanti, A., Wargasetia, T. L., Gunadi, J. W."Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review)". Biomedical Reports 23, no. 2 (2025): 131. https://doi.org/10.3892/br.2025.2009
Copy and paste a formatted citation
x
Spandidos Publications style
Evanti A, Wargasetia TL and Gunadi JW: Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review). Biomed Rep 23: 131, 2025.
APA
Evanti, A., Wargasetia, T.L., & Gunadi, J.W. (2025). Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review). Biomedical Reports, 23, 131. https://doi.org/10.3892/br.2025.2009
MLA
Evanti, A., Wargasetia, T. L., Gunadi, J. W."Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review)". Biomedical Reports 23.2 (2025): 131.
Chicago
Evanti, A., Wargasetia, T. L., Gunadi, J. W."Role of <em>Nigella sativa</em> L. seed (black cumin) in preventing photoaging (Review)". Biomedical Reports 23, no. 2 (2025): 131. https://doi.org/10.3892/br.2025.2009
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