Open Access

Exploring the potential of honokiol as a treatment for cardiovascular disease (Review)

  • Authors:
    • Yao Zeng
    • Zishan Li
    • Xiaolong Lin
  • View Affiliations

  • Published online on: June 10, 2025     https://doi.org/10.3892/br.2025.2012
  • Article Number: 134
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular diseases (CVDs) remain a leading cause of global mortality. As the burden of these diseases continues to rise, the development of innovative therapeutic agents has become increasingly important. Honokiol, a bioactive compound extracted from the bark and leaves of particular Magnolia species, has garnered attention for its wide‑ranging pharmacological effects, including anti‑inflammatory, antioxidant, and vasodilatory properties. Emerging research suggests that honokiol holds significant promise as a therapeutic agent for managing CVDs. The present review provides a comprehensive overview of the bioactive properties, cardiovascular effects, mechanisms of action, and potential clinical utility of honokiol for the treatment of CVDs. Furthermore, challenges and future directions for the clinical translation of honokiol are discussed at length to provide additional context.
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August-2025
Volume 23 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Zeng Y, Li Z and Lin X: Exploring the potential of honokiol as a treatment for cardiovascular disease (Review). Biomed Rep 23: 134, 2025.
APA
Zeng, Y., Li, Z., & Lin, X. (2025). Exploring the potential of honokiol as a treatment for cardiovascular disease (Review). Biomedical Reports, 23, 134. https://doi.org/10.3892/br.2025.2012
MLA
Zeng, Y., Li, Z., Lin, X."Exploring the potential of honokiol as a treatment for cardiovascular disease (Review)". Biomedical Reports 23.2 (2025): 134.
Chicago
Zeng, Y., Li, Z., Lin, X."Exploring the potential of honokiol as a treatment for cardiovascular disease (Review)". Biomedical Reports 23, no. 2 (2025): 134. https://doi.org/10.3892/br.2025.2012