Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-2025 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2025 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study

  • Authors:
    • Amani Alshahrani
    • Ziyad Mohammed Althani
    • Raidah Al-Baradie
    • Tarek Jallul
    • Faisal Alotaibi
    • Ahmed Najjar
    • Mona Faraidy
    • Brent Hedgcock
    • Shahid Bashir
    • Ali Mir
  • View Affiliations / Copyright

    Affiliations: Department of Adult Neurology, King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia, Department of Pediatric Neurology, King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia, Department of Neurosurgery, King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia, Neuroscience Centre, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia, Department of Anesthesia, King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia, Department of Neurophysiology, King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia, Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam 31444, Saudi Arabia
    Copyright: © Alshahrani et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 171
    |
    Published online on: September 1, 2025
       https://doi.org/10.3892/br.2025.2049
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intraoperative electrocorticography (ECoG) represents a crucial tool for improving seizure outcomes during epilepsy surgeries by assisting in localization of the epileptogenic zones. There is a shortage of information in the literature regarding single‑center experiences and long‑term outcomes after ECoG‑guided surgeries. Data are particularly scarce from the Eastern Mediterranean Region. The aim of the present retrospective study was to investigate the effectiveness of ECoG‑guided epilepsy surgeries performed in a single center in terms of seizure outcomes. The study included 30 patients with drug‑resistant epilepsy who underwent ECoG‑guided surgeries between January 2013 and December 2024. Participant details, clinical history and data, surgical interventions, and outcomes were all reviewed retrospectively. The intraoperative findings were assessed and post‑resection ECoG was used to define the extent of resections. Of the 30 patients, 19 (63.3%) achieved complete seizure freedom (Engel Class I) post‑surgery. ECoG revealed zones of preexisting epileptogenic activity in all patients undergoing the procedure, with 43.3% of patients showing no residual interictal discharges on ECoG after resection. ECoG remains relevant in achieving improved outcomes in epilepsy surgery, with seizure freedom accurately predicted by post‑surgical ECoG silence. 
View Figures

Figure 1

Pre-resection electrocorticography
recording. This recording captures baseline cortical activity
before resection, showing periodic epileptiform discharges over the
inferior frontal region and some epileptiform discharges over the
mesial and lateral frontal regions, assisting in identifying
epileptogenic zones.

Figure 2

Post-resection electrocorticography
recording. This recording captures brain activity after the
resection of targeted areas. This recording is used to assess the
immediate impact of the surgery and verify that the epileptogenic
tissue has been removed.
View References

1 

Bell GS and Sander JW: The epidemiology of epilepsy: The size of the problem. Seizure. 10:306–314. 2002.PubMed/NCBI

2 

Dwivedi R, Ramanujam B, Chandra PS, Sapra S, Gulati S, Kalaivani M, Garg A, Bal CS, Tripathi M, Dwivedi SN, et al: Surgery for drug-resistant epilepsy in children. N Engl J Med. 377:1639–1647. 2017.PubMed/NCBI View Article : Google Scholar

3 

Guo J, Guo M, Liu R, Kong Y, Hu X, Yao L, Lv S, Lv J, Wang X and Kong QX: Seizure Outcome after surgery for refractory epilepsy diagnosed by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/MRI): A systematic review and Meta-analysis. World Neurosurg. 173:34–43. 2023.PubMed/NCBI View Article : Google Scholar

4 

Engel J Jr, McDermott MP, Wiebe S, Langfitt JT, Stern JM, Dewar S, Sperling MR, Gardiner I, Erba G, Fried I, et al: Early surgical therapy for drug-resistant temporal lobe epilepsy. JAMA. 307:922–930. 2012.PubMed/NCBI View Article : Google Scholar

5 

Harroud A, Bouthillier A, Weil AG and Nguyen DK: Temporal lobe epilepsy surgery failures: A review. Epilepsy Res Treat. 2012(201651)2012.PubMed/NCBI View Article : Google Scholar

6 

Nair DR, Mohamed A, Burgess R and Lüders H: A critical review of the different conceptual hypotheses framing human focal epilepsy. Epileptic Disord. 6:77–83. 2004.PubMed/NCBI

7 

Penfield W and Jasper H: Epilepsy and the functional anatomy of the human brain. Boston, Little, Brown & Co., Boston MA, pp363-365, 1954.

8 

Tripathi M, Garg A, Gaikwad S, Bal CS, Chitra S, Prasad K, Dash HH, Sharma BS and Chandra PS: Intra-operative electrocorticography in lesional epilepsy. Epilepsy Res. 89:133–141. 2010.PubMed/NCBI View Article : Google Scholar

9 

Yang T, Hakimian S and Schwartz TH: Intraoperative electrocorticography (ECoG): Indications, techniques, and utility in epilepsy surgery. Epileptic Disord. 16:271–279. 2014.PubMed/NCBI View Article : Google Scholar

10 

World Health Organization (WHO): Epilepsy in the WHO Eastern Mediterranean Region. WHO Regional Office for the Eastern Mediterranean, Cairo, 2010. https://applications.emro.who.int/dsaf/dsa1039.pdf.

11 

Engel J Jr: Outcome with respect to epileptic seizures. In: Surgical Treatment of the Epilepsies. Engel J Jr (ed). 2nd edition. Raven Press, New York, NY, pp609-621, 1993).

12 

Ravat S, Iyer V, Panchal K, Muzumdar D and Kulkarni A: Surgical outcomes in patients with intraoperative Electrocorticography (EcoG) guided epilepsy surgery-experiences of a tertiary care centre in India. Int J Surg. 36:420–428. 2016.PubMed/NCBI View Article : Google Scholar

13 

Greiner HM, Horn PS, Tenney JR, Arya R, Jain SV, Holland KD, Leach JL, Miles L, Rose DF, Fujiwara H and Mangano FT: Preresection intraoperative electrocorticography (ECoG) abnormalities predict Seizure-onset zone and outcome in pediatric epilepsy surgery. Epilepsia. 57:582–589. 2016.PubMed/NCBI View Article : Google Scholar

14 

Sugano H, Shimizu H and Sunaga S: Efficacy of intraoperative electrocorticography for assessing seizure outcomes in intractable epilepsy patients with temporal-lobe-mass lesions. Seizure. 16:120–127. 2007.PubMed/NCBI View Article : Google Scholar

15 

Fernández IS and Loddenkemper T: Electrocorticography for seizure foci mapping in epilepsy surgery. J Clin Neurophysiol. 30:554–570. 2013.PubMed/NCBI View Article : Google Scholar

16 

Chiba R, Enatsu R, Kanno A, Tamada T, Saito T, Sato R and Mikuni N: Usefulness of intraoperative electrocorticography for the localization of epileptogenic zones. Neurol Med Chir (Tokyo). 63:65–72. 2023.PubMed/NCBI View Article : Google Scholar

17 

Peng SJ, Wong TT, Huang CC, Chang H, Hsieh KL, Tsai ML, Yang YS and Chen CL: Quantitative analysis of intraoperative electrocorticography mirrors histopathology and seizure outcome after epileptic surgery in children. J Formos Med Assoc. 120:1500–1511. 2021.PubMed/NCBI View Article : Google Scholar

18 

Goel K, Pek V, Shlobin NA, Chen JS, Wang A, Ibrahim GM, Hadjinicolaou A, Roessler K, Dudley RW, Nguyen DK, et al: Clinical utility of intraoperative electrocorticography in epilepsy surgery: A systematic review and meta-analysis. Epilepsia. 64:253–265. 2023.PubMed/NCBI View Article : Google Scholar

19 

Pilcher WH, Silbergeld DL, Berger MS and Ojemann GA: Intraoperative electrocorticography during tumor resection: Impact on seizure outcome in patients with gangliogliomas. J Neurosurg. 78:891–902. 1993.PubMed/NCBI View Article : Google Scholar

20 

Jehi L, Yardi R, Chagin K, Tassi L, Russo GL, Worrell G, Hu W, Cendes F, Morita M, Bartolomei F, et al: Development and validation of nomograms to provide individualised predictions of seizure outcomes after epilepsy surgery: A retrospective analysis. Lancet Neurol. 14:283–290. 2015.PubMed/NCBI View Article : Google Scholar

21 

Téllez-Zenteno JF, Hernández-Ronquillo L, Moien-Afshari F and Wiebe S: Surgical outcomes in lesional and non-lesional epilepsy: A systematic review and meta-analysis. Epilepsy Res. 89:310–318. 2010.PubMed/NCBI View Article : Google Scholar

22 

Benamer HT and Grosset DG: A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia. 50:2301–2304. 2009.PubMed/NCBI View Article : Google Scholar

23 

Idris A, Alabdaljabar MS, Almiro A, Alsuraimi A, Dawalibi A, Abduljawad S and AlKhateeb M: Prevalence, incidence, and risk factors of epilepsy in Arab countries: A systematic review. Seizure. 92:40–50. 2021.PubMed/NCBI View Article : Google Scholar

24 

Alfayez SM and Aljafen BN: Epilepsy services in Saudi Arabia. Quantitative assessment and identification of challenges. Neurosciences (Riyadh). 21:326–330. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Alshahrani A, Althani ZM, Al-Baradie R, Jallul T, Alotaibi F, Najjar A, Faraidy M, Hedgcock B, Bashir S, Mir A, Mir A, et al: Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study. Biomed Rep 23: 171, 2025.
APA
Alshahrani, A., Althani, Z.M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A. ... Mir, A. (2025). Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study. Biomedical Reports, 23, 171. https://doi.org/10.3892/br.2025.2049
MLA
Alshahrani, A., Althani, Z. M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A., Faraidy, M., Hedgcock, B., Bashir, S., Mir, A."Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study". Biomedical Reports 23.5 (2025): 171.
Chicago
Alshahrani, A., Althani, Z. M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A., Faraidy, M., Hedgcock, B., Bashir, S., Mir, A."Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study". Biomedical Reports 23, no. 5 (2025): 171. https://doi.org/10.3892/br.2025.2049
Copy and paste a formatted citation
x
Spandidos Publications style
Alshahrani A, Althani ZM, Al-Baradie R, Jallul T, Alotaibi F, Najjar A, Faraidy M, Hedgcock B, Bashir S, Mir A, Mir A, et al: Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study. Biomed Rep 23: 171, 2025.
APA
Alshahrani, A., Althani, Z.M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A. ... Mir, A. (2025). Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study. Biomedical Reports, 23, 171. https://doi.org/10.3892/br.2025.2049
MLA
Alshahrani, A., Althani, Z. M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A., Faraidy, M., Hedgcock, B., Bashir, S., Mir, A."Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study". Biomedical Reports 23.5 (2025): 171.
Chicago
Alshahrani, A., Althani, Z. M., Al-Baradie, R., Jallul, T., Alotaibi, F., Najjar, A., Faraidy, M., Hedgcock, B., Bashir, S., Mir, A."Intraoperative electrocorticography in focal drug‑resistant epilepsy: A 10‑year retrospective single‑center study". Biomedical Reports 23, no. 5 (2025): 171. https://doi.org/10.3892/br.2025.2049
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team