|
1
|
Brownlee M: The pathobiology of diabetic
complications: A unifying mechanism. Diabetes. 54:1615–1625.
2005.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Cheung LYM, George AS, McGee SR, Daly AZ,
Brinkmeier ML, Ellsworth BS and Camper SA: Single-cell RNA
sequencing reveals novel markers of male pituitary stem cells and
hormone-producing cell types. Endocrinology. 159:3910–3924.
2018.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Ashpole NM, Sanders JE, Hodges EL, Yan H
and Sonntag WE: Growth hormone, insulin-like growth factor-1 and
the aging brain. Exp Gerontol. 68:76–81. 2015.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Darvin P, Joung YH and Yang YM:
JAK2-STAT5B pathway and osteoblast differentiation. JAK-STAT.
2(e24931)2013.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Laron Z: Insulin-like growth factor 1
(IGF-1): A growth hormone. Mol Pathol. 54:311–316. 2001.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Uematsu S and Akira S: The role of
Toll-like receptors in immune disorders. Expert Opin Biol Th.
6:203–214. 2006.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Kumar H, Kawai T and Akira S: Toll-like
receptors and innate immunity. Biochem Bioph Res Co. 388:621–625.
2009.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Oberbauer A: The Regulation of IGF-1 gene
transcription and splicing during development and aging. Front
Endocrinol (Lausanne). 4(39)2013.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Varco-Merth B and Rotwein P: Differential
effects of STAT proteins on growth hormone-mediated IGF-I gene
expression. Am J Physiol Endocrinol Metab. 307:E847–E855.
2014.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Hu X, Li J, Fu M, Zhao X and Wang W: The
JAK/STAT signaling pathway: From bench to clinic. Sig Transduct
Target Ther. 6(402)2021.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Zhu T, Goh ELK, Graichen R, Ling L and
Lobie PE: Signal transduction via the growth hormone receptor. Cell
Signal. 13:599–616. 2001.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Callaway JC: Hempseed as a nutritional
resource: An overview. Euphytica. 140:65–72. 2004.
|
|
13
|
Barbara F, Romina M, Nicolò LC and
Merendino N: The seed of industrial hemp (Cannabis sativa
L.): Nutritional Quality and Potential Functionality for Human
Health and Nutrition. Nutrients. 12(1935)2020.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Salehi A, Puchalski K, Shokoohinia Y,
Zolfaghari B and Asgary S: Differentiating Cannabis products:
Drugs, food, and supplements. Front Pharmacol.
13(906038)2022.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Pellegrino C, CB 00A0 and Jacopo GC: A
review of hemp as food and nutritional supplement. Cannabis
Cannabinoid Res. 6:19–27. 2021.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Sirangelo TM, Diretto G, Fiore A, Felletti
S, Chenet T, Catani M and Spadafora ND: Nutrients and bioactive
compounds from cannabis sativa seeds: A review focused on
Omics-based investigations. Int J Mol Sci. 26(5219)2025.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Tănase Apetroaei V, Pricop EM, Istrati DI
and Vizireanu C: Hemp seeds (Cannabis sativa L.) as a
valuable source of natural ingredients for functional foods.
Molecules. 29(2097)2024.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Hossain L, Whitney K and Simsek S: Hemp
seed as an emerging source of nutritious functional ingredients.
Crit Rev Food Sci Nutr: 1-17, 2025 doi:
10.1080/10408398.2025.2534839 (Epub ahead of print).
|
|
19
|
Chen T, He J, Zhang J, Zhang H, Qian P,
Hao J and Li L: Analytical characterization of Hempseed (seed of
Cannabis sativa L.) oil from eight regions in China. J Diet
Suppl. 7:117–129. 2010.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Roche HM: Unsaturated fatty acids. Proc
Nutr Soc. 58:397–401. 1999.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Saini RK and Keum YS: Omega-3 and omega-6
polyunsaturated fatty acids: Dietary sources, metabolism, and
significance-A review. Life Sci. 203:255–267. 2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Jin S and Lee MY: The ameliorative effect
of hemp seed hexane extracts on the Propionibacterium acnes-induced
inflammation and lipogenesis in sebocytes. PLoS One.
13(202933)2018.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Lin YA, Li YR, Chang YC, Hsu MC and Chen
ST: Activation of IGF-1 pathway and suppression of atrophy related
genes are involved in Epimedium extract (icariin) promoted C2C12
myotube hypertrophy. Sci Rep. 11(10790)2021.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Sadowski CL, Wheeler TT, Wang LH and
Sadowski HB: GH Regulation of IGF-I and suppressor of cytokine
signaling gene expression in C2C12 skeletal muscle cells.
Endocrinology. 142:3890–3900. 2001.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Ker DF, Sharma R, Wang ET and Yang YP:
Development of mRuby2-transfected C3H10T1/2 fibroblasts for
musculoskeletal tissue engineering. PLoS One.
10(e0139054)2015.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Milasincic DJ, Calera MR, Farmer SR and
Pilch PF: Stimulation of C2C12 myoblast growth by basic fibroblast
growth factor and insulin-like growth factor 1 can occur via
mitogen-activated protein kinase-dependent and -independent
pathways. Mol Cell Biol. 16:5964–5973. 1996.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Hwangbo Y and Kim JH, Kim T and Kim JH:
Effects of hemp seed protein hydrolysates on the differentiation of
C2C12 cells and muscle atrophy. J Korean Soc Food Sci Nutr.
52:1225–1232. 2023.
|
|
28
|
Hwangbo Y, Pan JH, Lee JJ, Kim T and Kim
JH: Production of protein hydrolysates from hemp (Cannabis
sativa L.) seed and its protective effects against
dexamethasone-induced muscle atrophy. Food Biosci.
59(104046)2024.
|
|
29
|
Kim D, Kim NP and Kim B: Effects of
biomaterials derived from germinated hemp seeds on stressed hair
stem cells and immune cells. Int J Mol Sci. 25(7823)2024.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Azqueta A, Stopper H, Zegura B, Dusinska M
and Møller P: Do cytotoxicity and cell death cause false positive
results in the in vitro comet assay? Mutat Res Genet Toxicol
Environ Mutagen. 881(503520)2022.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Kassem M, Blum W, Ristelli J, Mosekilde L
and Eriksen EF: Growth hormone stimulates proliferation and
differentiation of normal human Osteoblast-like cells in vitro.
Calcif Tissue Int. 52:222–226. 1993.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Waters MJ and Brooks AJ: Growth hormone
and cell growth. Endocr Dev. 23:86–95. 2012.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Caron JM, Bannon M, Rosshirt L, Luis J,
Monteagudo L, Caron JM and Sternstein GM: Methyl sulfone induces
loss of metastatic properties and reemergence of normal phenotypes
in a metastatic cloudman S-91 (M3) murine melanoma cell line. PLoS
One. 5(e11788)2010.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Kang DY, Sp N, Jo ES, Kim HD, Kim IH, Bae
SW, Jang KJ and Yang YM: Non-toxic sulfur enhances growth hormone
signaling through the JAK2/STAT5b/IGF-1 pathway in C2C12 cells. Int
J Mol Med. 45:931–938. 2020.PubMed/NCBI View Article : Google Scholar
|
|
36
|
van den Beld AW, Kaufman JM, Zillikens MC,
Lamberts SWJ, Egan JM and van der Lely AJ: The physiology of
endocrine systems with ageing. Lancet Diabetes Endocrinol.
6:647–658. 2018.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Tadashi Y and Delafontaine P: Mechanisms
of IGF-1-Mediated regulation of skeletal muscle hypertrophy and
atrophy. Cells. 9(1970)2020.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Mukama T, Srour B, Johnson T, Katzke V and
Kaaks R: IGF-1 and risk of morbidity and mortality from cancer,
cardiovascular diseases, and all causes in EPIC-Heidelberg. J Clin
Endocrinol Metab. 108:e1092–e1105. 2023.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Ricci Bitti S, Franco M, Albertelli M,
Gatto F, Vera L, Ferone D and Boschetti M: GH Replacement in the
elderly: Is it worth it? Front Endocrinol (Lausanne).
12(680579)2021.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Silvia G, Emanuele M, Stephen E and
Christiaan L: Modulation of GH/IGF-1 axis: Potential strategies to
counteract sarcopenia in older adults. Mech Ageing Dev.
129:593–601. 2008.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Maggio M, De Vita F, Lauretani F, Buttò V,
Bondi G, Cattabiani C, Nouvenne A, Meschi T, Dall'Aglio E and Ceda
GP: IGF-1, the crossroad of the nutritional, inflammatory and
hormonal pathways to frailty. Nutrients. 5:4184–4205.
2013.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Barclay RD, Burd NA, Tyler C, Tillin NA
and Mackenzie RW: The role of the IGF-1 signaling cascade in muscle
protein synthesis and anabolic resistance in aging skeletal muscle.
Front Nutr. 6(146)2019.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Yue X, Hao W, Wang M and Fu Y: Astragalus
polysaccharide ameliorates insulin resistance in HepG2 cells
through activating the STAT5/IGF-1 pathway. Immun Inflamm Dis.
11(e1071)2023.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Li Z, Dai X, Yang F, Zhao W, Xiong Z, Wan
W, Wu G, Xu T and Cao H: Compound probiotics promote the growth of
piglets through activating the JAK2/STAT5 signaling pathway. Front
Microbiol. 16(1480077)2025.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Ma IL and Stanley TL: Growth hormone and
nonalcoholic fatty liver disease. Immunometabolism.
5(e00030)2023.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Dichtel LE, Cordoba-Chacon J and Kineman
RD: Growth hormone and insulin-like growth factor 1 regulation of
nonalcoholic fatty liver disease. J Clin Endocrinol Metab.
107:1812–1824. 2022.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Fedorczak A, Lewiński A and Stawerska R:
Involvement of sirtuin 1 in the growth hormone/insulin-like growth
factor 1 signal transduction and its impact on growth processes in
children. Int J Mol Sci. 24(15406)2023.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Jiang LH, Yang NY, Yuan XL, Zou YJ, Zhao
FM, Chen JP, Wang MY and Lu DX: Daucosterol promotes the
proliferation of neural stem cells. J Steroid Biochem Mol Biol.
140:90–99. 2014.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Kim HK, Kim MG and Leem KH: Icariin
stimulates myogenic differentiation and enhances muscle
regeneration in injured skeletal muscle. Biol Pharm Bull.
39:455–462. 2016.
|
|
50
|
Klover P and Hennighausen L: Postnatal
body growth is dependent on the transcription factors signal
transducers and activators of transcription 5a/b in muscle: a role
for autocrine/paracrine insulin-like growth factor I.
Endocrinology. 148:1489–1497. 2007.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Klover P, Chen W, Zhu BM and Hennighausen
L: Skeletal muscle growth and fiber composition in mice are
regulated through the transcription factors STAT5a/b: Linking
growth hormone to the androgen receptor. FASEB J. 23:3140–3148.
2009.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Joshi AS, da Silva MT, Kumar S and Kumar
A: Signaling networks governing skeletal muscle growth, atrophy,
and cachexia: By. Skeletal Muscle. 15(29)2025.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Schiaffino S and Mammucari C: Regulation
of skeletal muscle growth by the IGF1-Akt/PKB pathway: Insights
from genetic models. Skelet Muscle. 1(4)2011.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Rommel C, Bodine SC, Clarke BA, Rossman R,
Nunez L, Stitt TN, Yancopoulos GD and Glass DJ: Mediation of
IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and
PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 3:1009–1013.
2001.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Sandri M, Sandri C, Gilbert A, Skurk C,
Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH and Goldberg
AL: Foxo transcription factors induce the atrophy-related ubiquitin
ligase atrogin-1 and cause skeletal muscle atrophy. Cell.
117:399–412. 2004.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Wu Z, Woodring PJ, Bhakta KS, Tamura K,
Wen F, Feramisco JR, Karin M, Wang JY and Puri PL: p38 and
extracellular signal-regulated kinases regulate the myogenic
program at multiple steps. Mol Cell Biol. 20:3951–3964.
2000.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Zetser A, Gredinger E and Bengal E: p38
mitogen-activated protein kinase pathway promotes skeletal muscle
differentiation. Participation of the Mef2c transcription factor. J
Biol Chem. 274:5193–5200. 1999.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Chauhan A: Nutrition and health benefits
of hemp-seed protein (Cannabis sativa L.). Pharma
Innovation. 10:16–19. 2021.
|
|
59
|
Jeromson S, Gallagher IJ, Galloway SDR and
Hamilton DL: Omega-3 fatty acids and skeletal muscle health. Mar
Drugs. 13:6977–7004. 2015.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Hnia K, Gayraud J, Hugon G, Ramonatxo M,
De La Porte S, Matecki S and Mornet D: L-arginine decreases
inflammation and modulates the nuclear factor-kappaB/matrix
metalloproteinase cascade in mdx muscle fibers Am J. Pathol.
172:1509–1519. 2008.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Greene JM, Feugang JM, Pfeiffer KE, Stokes
JV, Bowers SD and Ryan PL: L-arginine enhances cell proliferation
and reduces apoptosis in human endometrial RL95-2 cells. Reprod
Biol Endocrinol. 11(15)2013.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Jin CL, Ye JL, Yang J, Gao CQ, Yan HC, Li
HC and Wang XQ: mTORC1 mediates lysine-induced satellite cell
activation to promote skeletal muscle growth. Cells.
8(1549)2019.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Sun X, Sun Y, Li Y, Wu Q and Wang L:
Identification and characterization of the seed storage proteins
and related genes of Cannabis sativa L. Front Nutr.
8(678421)2021.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Barakat H and Aljutaily T: Hemp-based meat
analogs: An updated review on nutritional and functional
properties. Foods. 14(2835)2025.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Joung YH, Lim EJ, Darvin P, Chung SC, Jang
JW, Park KD, Lee HK, Kim HS, Park T and Yang YM: MSM enhances GH
signaling via the Jak2/STAT5b pathway in osteoblast-like cells and
osteoblast differentiation through the activation of STAT5b in
MSCs. PLoS One. 7(e47477)2012.PubMed/NCBI View Article : Google Scholar
|
