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Association of PLA2G2A single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population

  • Authors:
    • Elvis Ngwa Ndonwi
    • Unati Nqebelele
    • Tandi Edith Matsha
    • Andre Pascal Kengne
  • View Affiliations / Copyright

    Affiliations: South African Medical Research Council/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape 7535, South Africa, Non‑Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, Western Cape 7505, South Africa
    Copyright: © Ndonwi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
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    Published online on: November 25, 2025
       https://doi.org/10.3892/br.2025.2091
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Abstract

While single nucleotide polymorphisms (SNPs) of the phospholipase A2 (PLA2) gene have been associated with cardiometabolic diseases (CMDs), such associations are yet to be demonstrated in a human immunodeficiency virus (HIV)‑infected African population. Therefore, the association between SNPs of the PLA2 gene and CMDs in a South African population with HIV was investigated. This cross‑sectional study included 716 participants recruited from HIV clinics in Cape Town, South Africa. Hardy‑Weinberg equilibrium (HWE) was assessed for the SNPs investigated. CMDs were compared across the genotypes of the SNPs in HWE. Linear and logistic regression analyses, adjusting for age and sex were used to assess the risk of CMDs across the genotypes. Among the SNPs investigated, rs4744 with GG (dominant) and AA (recessive) genotypes were in HWE (P=0.998). High‑density lipoprotein‑cholesterol (HDL‑C; P=0.044) and a BMI ≥30 kg/m2 (P=0.037) were significantly higher in participants with the dominant genotype compared with those with the recessive genotype of the rs4744 SNP. Moreover, the rs4744 recessive genotype was associated with dyslipidemia characterized by low HDL‑C in linear regression (β=0.366; P=0.024) and logistic regression (OR=0.19; P=0.049), and also associated with MetS in logistic regression (OR=0.14; P=0.036). In conclusion, the phospholipase A2 group IIA (PLA2G2A) gene has a potential utility for CMD risk assessment in African individuals with HIV.
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Figure 1

Antiviral therapy regimens used. ART,
antiretroviral therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Ndonwi EN, Nqebelele U, Matsha TE and Kengne AP: Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population. Biomed Rep 24: 18, 2026.
APA
Ndonwi, E.N., Nqebelele, U., Matsha, T.E., & Kengne, A.P. (2026). Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population. Biomedical Reports, 24, 18. https://doi.org/10.3892/br.2025.2091
MLA
Ndonwi, E. N., Nqebelele, U., Matsha, T. E., Kengne, A. P."Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population". Biomedical Reports 24.2 (2026): 18.
Chicago
Ndonwi, E. N., Nqebelele, U., Matsha, T. E., Kengne, A. P."Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population". Biomedical Reports 24, no. 2 (2026): 18. https://doi.org/10.3892/br.2025.2091
Copy and paste a formatted citation
x
Spandidos Publications style
Ndonwi EN, Nqebelele U, Matsha TE and Kengne AP: Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population. Biomed Rep 24: 18, 2026.
APA
Ndonwi, E.N., Nqebelele, U., Matsha, T.E., & Kengne, A.P. (2026). Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population. Biomedical Reports, 24, 18. https://doi.org/10.3892/br.2025.2091
MLA
Ndonwi, E. N., Nqebelele, U., Matsha, T. E., Kengne, A. P."Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population". Biomedical Reports 24.2 (2026): 18.
Chicago
Ndonwi, E. N., Nqebelele, U., Matsha, T. E., Kengne, A. P."Association of <em>PLA2G2A</em> single nucleotide polymorphism and cardiometabolic diseases in an HIV‑infected population". Biomedical Reports 24, no. 2 (2026): 18. https://doi.org/10.3892/br.2025.2091
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