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Review Open Access

Pharmacological properties of the ethnomedicinal plant Dodonaea viscosa: Anticancer potential and beyond (Review)

  • Authors:
    • Aaliyah Saferdien
    • Babalwa Yekelo
    • Shaheen Mowla
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Division of Haematology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
    Copyright: © Saferdien et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: January 29, 2026
       https://doi.org/10.3892/br.2026.2115
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Abstract

Continuous and rigorous assessment of the pharmacological potential of plants is essential for the discovery and development of novel anticancer and other therapeutic agents. Ongoing evaluation also ensures validation of traditional uses while optimizing efficacy and safety. The reporting of these evaluations serves to support innovation of the pharmaceutical landscape to advance evidence‑based medicine. Such is particularly important for research in cancer, a highly complex disease that remains a leading cause of mortality worldwide. Numerous conventional anticancer drugs are derived from natural products, highlighting the value of plants as a source of novel compounds with anticancer properties. The medicinal plant, Dodonaea viscosa (DV) is an evergreen shrub found in tropical and subtropical regions around the world, with a long history of use in traditional medicine. Different parts of the plant are used in diverse ways for a wide range of ailments by traditional healers. This review provides a comprehensive and updated summary of scientific investigations reporting on the anticancer and other therapeutic potential of DV. Investigations to date have primarily assessed whole DV aqueous and/or organic extracts of various solvents, with only few investigations of fractionated and purified isolates. Using a combination of in vitro assays and various animal models, extracts of DV and derivatives show promise as lead compounds for the development of anticancer drugs, including breast, gastric, liver and haematological malignancies. In addition, DV extracts harbour anti‑inflammatory, antibacterial, and antioxidant activities This suggests their value as a source of phytochemicals with therapeutic potential.
View Figures

Figure 1

Geographical distribution and major
phytocomponents of DV. (A) Worldwide view showing reported
geographical distribution of DV in the tropics and subtropics.
Alphabetical list of countries where DV is used in traditional
medicine: Afghanistan, Australasia and Pacific, Australia, Bolivia,
Brazil, China, Colombia, Ethiopia, India, Indonesia, Japan,
Madagascar, Mexico, New Zealand, Oman (Arabian Peninsula), Peru,
Philippines, South Africa, Sri Lanka, Sudan, Taiwan, Uruguay,
Hawaii. (B) Names and structural representation of six of the
prevailing compounds isolated from DV leaves using gas
chromatography-mass spectroscopy (20,21).
DV, Dodonaea viscosa.

Figure 2

Overview of cancer types in which DV
extracts have shown anticancer effects. Infographic showing cancer
types where DV extract has been demonstrated to have anticancer
effects, including types of extracts, dose treatment range, and
altered cancer-associated biological events (23,29,32-36).
View References

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Copy and paste a formatted citation
Spandidos Publications style
Saferdien A, Yekelo B and Mowla S: Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review). Biomed Rep 24: 42, 2026.
APA
Saferdien, A., Yekelo, B., & Mowla, S. (2026). Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review). Biomedical Reports, 24, 42. https://doi.org/10.3892/br.2026.2115
MLA
Saferdien, A., Yekelo, B., Mowla, S."Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review)". Biomedical Reports 24.4 (2026): 42.
Chicago
Saferdien, A., Yekelo, B., Mowla, S."Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review)". Biomedical Reports 24, no. 4 (2026): 42. https://doi.org/10.3892/br.2026.2115
Copy and paste a formatted citation
x
Spandidos Publications style
Saferdien A, Yekelo B and Mowla S: Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review). Biomed Rep 24: 42, 2026.
APA
Saferdien, A., Yekelo, B., & Mowla, S. (2026). Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review). Biomedical Reports, 24, 42. https://doi.org/10.3892/br.2026.2115
MLA
Saferdien, A., Yekelo, B., Mowla, S."Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review)". Biomedical Reports 24.4 (2026): 42.
Chicago
Saferdien, A., Yekelo, B., Mowla, S."Pharmacological properties of the ethnomedicinal plant <em>Dodonaea viscosa</em>: Anticancer potential and beyond (Review)". Biomedical Reports 24, no. 4 (2026): 42. https://doi.org/10.3892/br.2026.2115
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