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Article

Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis

  • Authors:
    • Elżbieta Grześk
    • Sylwia Kołtan
    • Robert Dębski
    • Mariusz  Wysocki
    • Marzena  Gruszka
    • Małgorzata  Kubicka
    • Andrzej  Kołtan
    • Grzegorz  Grześk
    • Sławomir Manysiak
    • Grażyna Odrowąż-Sypniewska
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, PL-85-094 Bydgoszcz, Poland, Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, PL-85-094 Bydgoszcz, Poland, Department of Pharmacology and Therapeutics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, PL-85-094 Bydgoszcz, Poland
  • Pages: 873-877
    |
    Published online on: July 20, 2010
       https://doi.org/10.3892/etm.2010.119
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Abstract

The pathogenesis of viral bronchiolitis is poorly understood. The aim of this study was to analyze interleukin (IL)-15, IL-18 and interferon (IFN)-γ concentrations and the activity of NK cells and CD4+ and CD8+ lymphocytes in 23 children not older than 30 months of age with acute viral bronchiolitis using blood samples drawn within the first 24 h of their hospital admission, in comparison to a healthy group. In children with bronchiolitis, the mean concentrations of IL-15, IL-18 and IFN-γ were 9.39±11.55, 884.03±645.44 and 17.92±27.14 pg/ml, respectively, and were significantly higher than those in the control group [2.34±0.61 pg/ml (p<0.05), 248.69±98.73 pg/ml (p<0.001) and 2.75±1.72 pg/ml (p<0.005), respectively]. In the bronchiolitis group, mean z-scores were -1.15±1.9 for CD4+ cells and -0.9±1.23 for CD8+ cells; these scores were significantly lower than those of the general Polish population (p<0.001 and <0.01, respectively). However, the mean z-score of the ratio of CD4+/CD8+ and the NK cell count in children with bronchiolitis did not differ significantly from those of the controls. In conclusion, cytokines such as IL-15, IL-18 and IFN-γ play a role in the pathogenesis of bronchiolitis in children.
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Copy and paste a formatted citation
Spandidos Publications style
Grześk E, Kołtan S, Dębski R, Wysocki M, Gruszka M, Kubicka M, Kołtan A, Grześk G, Manysiak S, Odrowąż-Sypniewska G, Odrowąż-Sypniewska G, et al: Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis. Exp Ther Med 1: 873-877, 2010.
APA
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M. ... Odrowąż-Sypniewska, G. (2010). Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis. Experimental and Therapeutic Medicine, 1, 873-877. https://doi.org/10.3892/etm.2010.119
MLA
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M., Kołtan, A., Grześk, G., Manysiak, S., Odrowąż-Sypniewska, G."Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis". Experimental and Therapeutic Medicine 1.5 (2010): 873-877.
Chicago
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M., Kołtan, A., Grześk, G., Manysiak, S., Odrowąż-Sypniewska, G."Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis". Experimental and Therapeutic Medicine 1, no. 5 (2010): 873-877. https://doi.org/10.3892/etm.2010.119
Copy and paste a formatted citation
x
Spandidos Publications style
Grześk E, Kołtan S, Dębski R, Wysocki M, Gruszka M, Kubicka M, Kołtan A, Grześk G, Manysiak S, Odrowąż-Sypniewska G, Odrowąż-Sypniewska G, et al: Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis. Exp Ther Med 1: 873-877, 2010.
APA
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M. ... Odrowąż-Sypniewska, G. (2010). Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis. Experimental and Therapeutic Medicine, 1, 873-877. https://doi.org/10.3892/etm.2010.119
MLA
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M., Kołtan, A., Grześk, G., Manysiak, S., Odrowąż-Sypniewska, G."Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis". Experimental and Therapeutic Medicine 1.5 (2010): 873-877.
Chicago
Grześk, E., Kołtan, S., Dębski, R., Wysocki, M., Gruszka, M., Kubicka, M., Kołtan, A., Grześk, G., Manysiak, S., Odrowąż-Sypniewska, G."Concentrations of IL-15, IL-18, IFN-γ and activity of CD4+, CD8+ and NK cells at admission in children with viral bronchiolitis". Experimental and Therapeutic Medicine 1, no. 5 (2010): 873-877. https://doi.org/10.3892/etm.2010.119
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