Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-October 2010 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2010 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma

  • Authors:
    • Nianhui Cui
    • Takeshi Nomura
    • Nobuo Takano
    • Enbo Wang
    • Wei Zhang
    • Takeshi Onda
    • Takahiko Shibahara
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China, Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
  • Pages: 755-760
    |
    Published online on: July 21, 2010
       https://doi.org/10.3892/etm.2010.128
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to examine the value of osteoclast-related cytokines in biopsy specimens for predicting mandibular invasion by oral squamous cell carcinoma (OSCC). In this retrospective study, biopsy specimens were obtained from 30 patients with OSCC. We observed the expression of seven osteoclast-related cytokines (IL-1α, RANKL, PTHrP, OPG, IL-6, RANK and TNF-α) using immunohistochemical (IHC) staining and of an osteoclast using tartrate-resistant acid phosphatase (TRAP) staining. The results were as follows: i) double-staining and IHC staining for RANKL, PTHrP and IL-1α in biopsy samples had diagnostic potential for predicting mandibular invasion; ii) TRAP-positive mono- or multinuclear cells were noted in the biopsy samples; iii) double-positive or -negative findings appeared to reliable indicate whether samples were invasion-positive or invasion-negative. Positive IHC staining for PTHrP, IL-1α or RANKL appeared to typically indicate an invasion-positive lesion. We suggest that the expression of both osteoclasts and osteoclast-related cytokines can be used to predict mandibular invasion.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1. 

Genden EM, Rinaldo A, Jacobson A, Shaha AR, Suarez C, Lowry J, Urguhart AC, Werner JA, Gullane PJ and Ferlito A: Management of mandibular invasion: when is a marginal mandibulectomy appropriate? Oral Oncol. 41:776–782. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Nakayama E, Yoshiura K, Ozeki S, Nakayama H, Yamaguchi T, Yoshikawa H, Kanda S, Ohishi M and Shirasuna K: The correlation of histological features with a panoramic radiography pattern and a computed tomography pattern of bone destruction in carcinoma of the mandibular gingival. Oral Surg Oral Med Oral Radiol Endod. 96:774–782. 2003. View Article : Google Scholar

3. 

Brockenbrough JM, Petruzzelli GJ and Lomasney L: Dentascan as an accurate method of predicting mandibular invasion in patients with squamous cell carcinoma of oral cavity. Arch Otolaryngol Head Neck Surg. 129:113–117. 2003. View Article : Google Scholar : PubMed/NCBI

4. 

Imaizumi A, Yoshino N, Yamada I, Nagumo K, Amagasa T, Omura K, Okada N and Kurabayashi T: A potential pitfall of MR imaging for assessing madibular invasion of squamous cell carcinoma in oral cavity. Am J Neuroradiol. 27:114–122. 2006.PubMed/NCBI

5. 

Ash CS, Nason RW, Abdoh AA and Cohen M: Prognostic implication of mandibular invasion in oral cancer. Head Neck. 22:794–798. 2000. View Article : Google Scholar : PubMed/NCBI

6. 

Shibahara T, Nomura T, Cui NH and Noma H: A study of osteoclast-related cytokines in mandibular invasion by squamous cell carcinoma. Int J Oral Maxillofac Surg. 34:789–793. 2005. View Article : Google Scholar : PubMed/NCBI

7. 

Tada T, Jimi E, Okamoto M, Ozeki S and Okabe K: Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteoprotegerin expression in osteoblasts. Int J Cancer. 116:253–262. 2005. View Article : Google Scholar : PubMed/NCBI

8. 

Dunne FP, Bowden SJ, Brown JS, Ratcliffe WA and Browne RM: Parathyroid hormone related protein in oral squamous cell carcinomas invading the mandible. J Clin Pathol. 48:300–303. 1995. View Article : Google Scholar : PubMed/NCBI

9. 

Cui N, Nomura T, Noma H, Yokoo K, Takagi R, Hashimoto S, Okamoto M, Sato M, Yu G, Guo C and Shibahara T: Effect of YM529 on a model of mandibular invasion by oral squamous cell carcinoma in mice. Clin Cancer Res. 11:2713–2719. 2005. View Article : Google Scholar : PubMed/NCBI

10. 

Lukinmaa PL, Hietanen J, Söderholm AL and Lindgvis C: The histologic pattern of bone invasion by squamous cell carcinoma of the mandibular region. Br J Oral Maxillofac Surg. 30:2–7. 1992. View Article : Google Scholar : PubMed/NCBI

11. 

Brown JS, Lowe D, Kalavrezos N, D'Souza J, Magennis P and Woolgar J: Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma. Head Neck. 24:370–383. 2002. View Article : Google Scholar : PubMed/NCBI

12. 

Azuma Y, Kaji K, Katogi R, Takeshita S and Kudo A: Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem. 275:4858–4864. 2000. View Article : Google Scholar : PubMed/NCBI

13. 

Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ and Suda T: Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med. 191:275–286. 2000. View Article : Google Scholar

14. 

Van de Wijingaert FP and Burger EH: Demonstration of tartrate-resistant acid phosphatase in un-decalcified, glycolmethacrylate-embedded mouse bone: a possible marker for (pre) osteoclast identification. J Histochem Cytochem. 34:1317–1323. 1986.

15. 

Cui NH, Zhang W, Wang EB, Wei MJ, Guo CB and Yu GY: Osteoclastic bone destruction and its regulating factors in oral squamous cell carcinoma. Beijing Da Xue Xue Bao. 39:30–32. 2007.PubMed/NCBI

16. 

Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, Khokha R, Wada T and Penninger JM: Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440:692–696. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cui N, Nomura T, Takano N, Wang E, Zhang W, Onda T and Shibahara T: Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma. Exp Ther Med 1: 755-760, 2010.
APA
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., & Shibahara, T. (2010). Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma. Experimental and Therapeutic Medicine, 1, 755-760. https://doi.org/10.3892/etm.2010.128
MLA
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., Shibahara, T."Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma". Experimental and Therapeutic Medicine 1.5 (2010): 755-760.
Chicago
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., Shibahara, T."Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma". Experimental and Therapeutic Medicine 1, no. 5 (2010): 755-760. https://doi.org/10.3892/etm.2010.128
Copy and paste a formatted citation
x
Spandidos Publications style
Cui N, Nomura T, Takano N, Wang E, Zhang W, Onda T and Shibahara T: Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma. Exp Ther Med 1: 755-760, 2010.
APA
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., & Shibahara, T. (2010). Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma. Experimental and Therapeutic Medicine, 1, 755-760. https://doi.org/10.3892/etm.2010.128
MLA
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., Shibahara, T."Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma". Experimental and Therapeutic Medicine 1.5 (2010): 755-760.
Chicago
Cui, N., Nomura, T., Takano, N., Wang, E., Zhang, W., Onda, T., Shibahara, T."Osteoclast-related cytokines from biopsy specimens predict mandibular invasion by oral squamous cell carcinoma". Experimental and Therapeutic Medicine 1, no. 5 (2010): 755-760. https://doi.org/10.3892/etm.2010.128
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team