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Article

Age-related changes in peripheral blood counts in humans

  • Authors:
    • Ulrich Mahlknecht
    • Simone Kaiser
  • View Affiliations / Copyright

    Affiliations: Department of Immunotherapy and Gene Therapy, Saarland University Medical Center, Kirrberger Strasse, Bldg. 45.3, D-66424 Homburg/Saar, Germany, Department of Hematology/Oncology, University of Heidelberg Medical Center, Heidelberg, Germany
  • Pages: 1019-1025
    |
    Published online on: September 17, 2010
       https://doi.org/10.3892/etm.2010.150
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Abstract

Anaemia has become a common concern in geriatric health. Since its prevalence varies quite significantly among different groups depending on factors such as ethnicity, lifestyle or fitness, the appropriateness of the current WHO definition of anaemia in the elderly may be questioned. We evaluated peripheral blood parameters from 1,724 individuals (908 women aged 18-101 years and 816 men aged 18-96 years), who were treated at the University of Heidelberg Medical Center with no known haematological history. Patients with a known malignant haematological or oncological disease or with chronic infection or inflammation were excluded. Patients with disorders affecting the kidneys, thyroid or stomach, as well as patients with a bleeding history, haemolysis or who had been previously diagnosed with anaemia were excluded from the study. Average haemoglobin levels for men beyond the age of 70 and for women beyond the age of 80 were found to fulfill the WHO criteria for the diagnosis of anaemia. While in our cohort ~20% of men and women between 60-69 years of age were by definition anaemic, these numbers steadily increased to 63% in females and 76% in males beyond the age of 90. Based on the results of our study and in accordance with the literature on this topic, we suggest age-adjusted criteria for the diagnosis of anaemia in the elderly in conjunction with a geriatric assessment.
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1. 

Zakai NA, Katz R, Hirsch C, et al: A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study. Arch Intern Med. 165:2214–2220. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Bohlius J, Wilson J, Seidenfeld J, et al: Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst. 98:708–714. 2006. View Article : Google Scholar : PubMed/NCBI

3. 

Castro OL, Haddy TB and Rana SR: Age- and sex-related blood cell values in healthy black Americans. Public Health Rep. 102:232–237. 1987.PubMed/NCBI

4. 

Izaks GJ and Westendorp RG: Ill or just old? Towards a conceptual framework of the relation between ageing and disease. BMC Geriatr. 3:72003. View Article : Google Scholar : PubMed/NCBI

5. 

Lugada ES, Mermin J, Kaharuza F, et al: Population-based hematologic and immunologic reference values for a healthy Ugandan population. Clin Diagn Lab Immunol. 11:29–34. 2004.PubMed/NCBI

6. 

Nilsson-Ehle H, Jagenburg R, Landahl S and Svanborg A: Blood haemoglobin declines in the elderly: implications for reference intervals from age 70 to 88. Eur J Haematol. 65:297–305. 2000. View Article : Google Scholar : PubMed/NCBI

7. 

Nordin G, Martensson A, Swolin B, et al: A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries. Scand J Clin Lab Invest. 64:385–398. 2004. View Article : Google Scholar : PubMed/NCBI

8. 

Tsang CW, Lazarus R, Smith W, Mitchell P, Koutts J and Burnett L: Hematological indices in an older population sample: derivation of healthy reference values. Clin Chem. 44:96–101. 1998.PubMed/NCBI

9. 

Akdag R, Energin VM, Kalayci AG and Karakelleoglu C: Reference limits for routine haematological measurements in 7–14-year-old children living at an intermediate altitude (1869 m, Erzurum, Turkey). Scand J Clin Lab Invest. 56:103–109. 1996.PubMed/NCBI

10. 

Bao W, Dalferes ER Jr, Srinivasan SR, Webber LS and Berenson GS: Normative distribution of complete blood count from early childhood through adolescence: the Bogalusa Heart Study. Prev Med. 22:825–837. 1993. View Article : Google Scholar : PubMed/NCBI

11. 

Serjeant GR, Grandison Y, Mason K, Serjeant B, Sewell A and Vaidya S: Haematological indices in normal Negro children: a Jamaican cohort from birth to five years. Clin Lab Haematol. 2:169–178. 1980.PubMed/NCBI

12. 

Shiga S, Koyanagi I, Ohsaga J, Ichiyama S and Kannagi R: [Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 2, reference values for white blood cell (WBC) count, WBC differential including segmented neutrophil, band neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet count and mean platelet volume]. Rinsho Byori. 47:281–288. 1999.

13. 

Nilsson-Ehle H, Jagenburg R, Landahl S, Svanborg A and Westin J: Haematological abnormalities and reference intervals in the elderly. A cross-sectional comparative study of three urban Swedish population samples aged 70, 75 and 81 years. Acta Med Scand. 224:595–604. 1988.

14. 

Marchant T, Schellenberg JA, Nathan R, et al: Anaemia in pregnancy and infant mortality in Tanzania. Trop Med Int Health. 9:262–266. 2004. View Article : Google Scholar : PubMed/NCBI

15. 

United_Nations: Population Division: World Population Prospects. The 2006 Revision. United Nations; New York, NY: 2007

16. 

Bundesamt S: German Population until 2060. Wiesbaden. 2009.

17. 

Kirkwood TB and Austad SN: Why do we age? Nature. 408:233–238. 2000. View Article : Google Scholar : PubMed/NCBI

18. 

Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 37:614–636. 1965. View Article : Google Scholar : PubMed/NCBI

19. 

Lipschitz DA, Udupa KB, Milton KY and Thompson CO: Effect of age on hematopoiesis in man. Blood. 63:502–509. 1984.PubMed/NCBI

20. 

Young DS: Pre-analytical variability in the elderly. Geriatr Clin Chem. 19–39. 1994.

21. 

Carpenter MA, Kendall RG, O’Brien AE, et al: Reduced erythropoietin response to anaemia in elderly patients with normocytic anaemia. Eur J Haematol. 49:119–121. 1992. View Article : Google Scholar : PubMed/NCBI

22. 

Kario K, Matsuo T, Kodama K, Nakao K and Asada R: Reduced erythropoietin secretion in senile anemia. Am J Hematol. 41:252–257. 1992. View Article : Google Scholar : PubMed/NCBI

23. 

Nafziger J, Pailla K, Luciani L, Andreux JP, Saint-Jean O and Casadevall N: Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly. Am J Hematol. 43:172–176. 1993. View Article : Google Scholar : PubMed/NCBI

24. 

Price EA and Schrier SL: Anemia in the elderly: introduction. Semin Hematol. 45:207–209. 2008. View Article : Google Scholar : PubMed/NCBI

25. 

Blanc B, Finch CA, Hallberg L, et al: Nutritional anaemias. Report of a WHO Scientific Group. WHO Tech Rep Ser. 405:1–40. 1968.

26. 

Lapin A and Bohmer F: [Laboratory findings in elderly patients: a forgotten aspect of laboratory medicine?]. Z Gerontol Geriatr. 32:41–46. 1999.

27. 

Kilpatrick GS and Hardisty RM: The prevalence of anaemia in the community. A survey of a random sample of the population. Br Med J. 1:778–782. 1961. View Article : Google Scholar : PubMed/NCBI

28. 

De Leeuw NK, Lowenstein L and Hsieh YS: Iron deficiency and hydremia in normal pregnancy. Medicine. 45:291–315. 1966.PubMed/NCBI

29. 

Sturgeon P: Studies of iron requirements in infants. III. Influence of supplemental iron during normal pregnancy on mother and infant. B. The infant. Br J Haematol. 5:45–55. 1959. View Article : Google Scholar

30. 

Natvig K: Studies on hemoglobin values in Norway. V. Hemoglobin concentration and hematocrit in men aged 15–21 years. Acta Med Scand. 180:613–620. 1966.PubMed/NCBI

31. 

Beutler E and Waalen J: The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 107:1747–1750. 2006. View Article : Google Scholar : PubMed/NCBI

32. 

Izaks GJ, Remarque EJ, Becker SV and Westendorp RG: Lymphocyte count and mortality risk in older persons. The Leiden 85-Plus Study. J Am Geriatr Soc. 51:1461–1465. 2003. View Article : Google Scholar : PubMed/NCBI

33. 

Melillo KD: Interpretation of laboratory values in older adults. Nurse Pract. 18:59–67. 1993. View Article : Google Scholar : PubMed/NCBI

34. 

Balducci L: Epidemiology of anemia in the elderly: information on diagnostic evaluation. J Am Geriatr Soc. 51:S2–S9. 2003. View Article : Google Scholar : PubMed/NCBI

35. 

Gabrilove J: Anemia and the elderly: clinical considerations. Best Pract Res Clin Haematol. 18:417–422. 2005. View Article : Google Scholar : PubMed/NCBI

36. 

Vogel JM: Hematologic problems of the aged. Mt Sinai J Med. 47:150–165. 1980.PubMed/NCBI

37. 

Wagner W, Bork S, Horn P, et al: Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One. 4:e58462009. View Article : Google Scholar : PubMed/NCBI

38. 

Waterstrat A and Van Zant G: Effects of aging on hematopoietic stem and progenitor cells. Curr Opin Immunol. 21:408–413. 2009. View Article : Google Scholar : PubMed/NCBI

39. 

Rossi DJ, Jamieson CH and Weissman IL: Stems cells and the pathways to aging and cancer. Cell. 132:681–696. 2008. View Article : Google Scholar : PubMed/NCBI

40. 

Longo DL: Closing in on a killer: anemia in elderly people. J Gerontol A Biol Sci Med Sci. 60:727–728. 2005. View Article : Google Scholar : PubMed/NCBI

41. 

Burkhardt R, Kettner G, Bohm W, et al: Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone. 8:157–164. 1987. View Article : Google Scholar

42. 

Aapro MS, Cella D and Zagari M: Age, anemia, and fatigue. Semin Oncol. 29:55–59. 2002. View Article : Google Scholar

43. 

Goldstein S: The biology of aging. N Engl J Med. 285:1120–1129. 1971. View Article : Google Scholar

44. 

Hartsock RJ, Smith EB and Petty CS: Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol. 43:326–331. 1965.

45. 

Baldwin JG Jr: True anemia: incidence and significance in the elderly. Geriatrics. 44:33–36. 1989.PubMed/NCBI

46. 

Baldwin JG Jr: Hematopoietic function in the elderly. Arch Intern Med. 148:2544–2546. 1988. View Article : Google Scholar : PubMed/NCBI

47. 

Eisenstaedt R, Penninx BW and Woodman RC: Anemia in the elderly: current understanding and emerging concepts. Blood Rev. 20:213–226. 2006. View Article : Google Scholar : PubMed/NCBI

48. 

Nilsson-Ehle H, Jagenburg R, Landahl S, Svanborg A and Westin J: Decline of blood haemoglobin in the aged: a longitudinal study of an urban Swedish population from age 70 to 81. Br J Haematol. 71:437–442. 1989. View Article : Google Scholar : PubMed/NCBI

49. 

Patel KV: Epidemiology of anemia in older adults. Semin Hematol. 45:210–217. 2008. View Article : Google Scholar : PubMed/NCBI

50. 

Karnofsky DA and Burchenal JH: The Clinical Evaluation of Chemotherapeutic Agents in Cancer. Columbia University Press; New York: 1949

51. 

Oken MM, Creech RH, Tormey DC, et al: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mahlknecht U and Kaiser S: Age-related changes in peripheral blood counts in humans. Exp Ther Med 1: 1019-1025, 2010.
APA
Mahlknecht, U., & Kaiser, S. (2010). Age-related changes in peripheral blood counts in humans. Experimental and Therapeutic Medicine, 1, 1019-1025. https://doi.org/10.3892/etm.2010.150
MLA
Mahlknecht, U., Kaiser, S."Age-related changes in peripheral blood counts in humans". Experimental and Therapeutic Medicine 1.6 (2010): 1019-1025.
Chicago
Mahlknecht, U., Kaiser, S."Age-related changes in peripheral blood counts in humans". Experimental and Therapeutic Medicine 1, no. 6 (2010): 1019-1025. https://doi.org/10.3892/etm.2010.150
Copy and paste a formatted citation
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Spandidos Publications style
Mahlknecht U and Kaiser S: Age-related changes in peripheral blood counts in humans. Exp Ther Med 1: 1019-1025, 2010.
APA
Mahlknecht, U., & Kaiser, S. (2010). Age-related changes in peripheral blood counts in humans. Experimental and Therapeutic Medicine, 1, 1019-1025. https://doi.org/10.3892/etm.2010.150
MLA
Mahlknecht, U., Kaiser, S."Age-related changes in peripheral blood counts in humans". Experimental and Therapeutic Medicine 1.6 (2010): 1019-1025.
Chicago
Mahlknecht, U., Kaiser, S."Age-related changes in peripheral blood counts in humans". Experimental and Therapeutic Medicine 1, no. 6 (2010): 1019-1025. https://doi.org/10.3892/etm.2010.150
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