Induced pluripotent stem cell technology and stem cell therapy for diabetes (Review)

Drummond,Robert  J.; Kunath,Tilo; Mee,P.   Joseph; Ross,James A.

doi:10.3892/etm.2010.173

Induced pluripotent stem cell technology and stem cell therapy for diabetes (Review)

Authors:
- Robert J. Drummond
- Tilo Kunath
- P. Joseph Mee
- James A. Ross
View Affiliations

Affiliations: Tissue Injury and Repair Group, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland EH16 4SB, UK, Early Embryonic Lineages Group, Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland EH9 3JQ, UK, Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland EH9 3JQ, UK
Published online on: December 2, 2010 https://doi.org/10.3892/etm.2010.173
Pages: 3-7

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Abstract

Although diabetes can be managed clinically with the use of insulin injections, it remains an incurable and inconvenient disorder. In the long-term, it is associated with a number of clinical complications, such as cardiovascular disease, resulting in a desire for the development of new methodologies to replace defective cells and provide a lasting normality without the need for drug treatment. Stem cells, including induced pluripotent stem cells, offer the possibility of generating cells suitable for transplantation due to their capacity to differentiate into all tissue lineages. However, many issues must be addressed before this type of treatment becomes a reality, including the need for a greater understanding of the underlying biology involved in the onset of diabetes.

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