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Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer

  • Authors:
    • Kiyotaka Okuno
    • Fumiaki Sugiura
    • Jin-ichi Hida
    • Tadao Tokoro
    • Eizaburo Ishimaru
    • Yasushi Sukegawa
    • Kazuki Ueda
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kinki University Faculty of Medicine, Osaka-sayama 589-8511, Japan, Institute of Immunotherapy for Cancer, Kinki University Faculty of Medicine, Osaka-sayama 589-8511, Japan
  • Pages: 73-79
    |
    Published online on: December 2, 2010
       https://doi.org/10.3892/etm.2010.182
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Abstract

To test the safety and immune responses of a novel peptide vaccine derived from RNF43 (ring finger protein 43) and TOMM34 (34-kDa translocase of the outer mitochondrial membrane) administered in combination with chemotherapy in patients with metastatic colorectal cancer, a phase I clinical trial with 21 HLA-A2402-positive metastatic colorectal cancer patients was conducted. Patients received a weekly peptide vaccine (1 mg of each peptide in incomplete Freund's adjuvant) in combination with oral UFT (300 mg/m2/day) and UZEL (75 mg/day) for 4 weeks, followed by 1 week of rest. The protocol consisted of at least two cycles of this regimen. After the 2nd cycle, vaccinations were given biweekly or monthly, depending on the condition of the patient. Clinical responses were judged 10 weeks after the 2nd cycle by performing computed tomography (CT) scans and assessing the cytotoxic T lymphocyte (CTL) responses against RNF43 and TOMM34 in peripheral lymphocytes. The vaccinations were well tolerated without any serious adverse events. CTL responses were induced against both antigens in 8 patients and against one antigen in 12 patients, while 1 patient had no CTL response. The rate of stable disease was 83%. The group with CTL responses against both antigens had the most long-term survivors, followed by the group showing CTL responses against one antigen (p=0.0079). The patients with no CTL responses had the lowest survival. The safety and immunological responsiveness of the present combination therapy suggests that it is clinically beneficial for metastatic colorectal cancer. Further clinical trials are warranted.
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1. 

Lin YM, Furukawa Y, Tsunoda T, Yue CT, Yang KC and Nakamura Y: Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene. 21:4120–4128. 2002. View Article : Google Scholar : PubMed/NCBI

2. 

Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T and Nakamura Y: A novel oncoprotein RNF43 functions in autocrine manner in colorectal cancer. Int J Oncol. 25:1343–1348. 2004.PubMed/NCBI

3. 

Chewawiwat N, Yano M, Terada M, Hoogenraad NJ and Mori M: Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells. J Biochem. 125:721–727. 1999. View Article : Google Scholar : PubMed/NCBI

4. 

Shimokawa T, Matsushima S, Tsunoda T, Tahara H, Nakamura Y and Furukawa Y: Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. Int J Oncol. 29:381–386. 2006.PubMed/NCBI

5. 

Hattori T, Mine T, Komatsu N, et al: Immunological evaluation of personalized peptide vaccination in combination with UFT and UZEL for metastatic colorectal carcinoma patients. Cancer Immunol Immunother. 58:1845–1854. 2009. View Article : Google Scholar

6. 

Uchida N, Tsunoda T, Wada S, Furukawa Y, Nakamura Y and Tahara H: Ring finger protein 43 as a new target for cancer immunotherapy. Clin Cancer Res. 10:8577–8586. 2004. View Article : Google Scholar : PubMed/NCBI

7. 

Shirao K, Hoff PM, Ohtsu A, et al: Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV. J Clin Oncol. 22:3466–3474. 2004. View Article : Google Scholar

8. 

Kono K, Mizukami Y, Daigo Y, et al: Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer. Cancer Sci. 100:1502–1509. 2009. View Article : Google Scholar

9. 

Correale P, Del Vecchio MT, Genova GD, et al: 5-Fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst. 97:1437–1445. 2005. View Article : Google Scholar

10. 

Correale P, Cusi MG, Tsang KY, et al: Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J Clin Oncol. 23:8950–8958. 2005.

11. 

Nagorsen D and Thiel E: HLA typing demands for peptide-based anti-cancer vaccine. Cancer Immunol Immunother. 57:1903–1910. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Liu K, Wang C, Chen L, et al: Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A0201 and HLA-A2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides. Clin Cancer Res. 10:2645–2651. 2004. View Article : Google Scholar

13. 

Weihrauch MR, Ansen S, Jurkiewicz E, et al: Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer. Clin Cancer Res. 11:5993–6001. 2005. View Article : Google Scholar

14. 

Dittmann J, Keller-Matschke K, Weinschenk T, et al: CD8+ T-cell response against MUC-1-derived peptides in gastrointestinal cancer survivors. Cancer Immunol Immunother. 54:750–758. 2005.

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Copy and paste a formatted citation
Spandidos Publications style
Okuno K, Sugiura F, Hida J, Tokoro T, Ishimaru E, Sukegawa Y and Ueda K: Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Exp Ther Med 2: 73-79, 2011.
APA
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., & Ueda, K. (2011). Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Experimental and Therapeutic Medicine, 2, 73-79. https://doi.org/10.3892/etm.2010.182
MLA
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., Ueda, K."Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer". Experimental and Therapeutic Medicine 2.1 (2011): 73-79.
Chicago
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., Ueda, K."Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer". Experimental and Therapeutic Medicine 2, no. 1 (2011): 73-79. https://doi.org/10.3892/etm.2010.182
Copy and paste a formatted citation
x
Spandidos Publications style
Okuno K, Sugiura F, Hida J, Tokoro T, Ishimaru E, Sukegawa Y and Ueda K: Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Exp Ther Med 2: 73-79, 2011.
APA
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., & Ueda, K. (2011). Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Experimental and Therapeutic Medicine, 2, 73-79. https://doi.org/10.3892/etm.2010.182
MLA
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., Ueda, K."Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer". Experimental and Therapeutic Medicine 2.1 (2011): 73-79.
Chicago
Okuno, K., Sugiura, F., Hida, J., Tokoro, T., Ishimaru, E., Sukegawa, Y., Ueda, K."Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer". Experimental and Therapeutic Medicine 2, no. 1 (2011): 73-79. https://doi.org/10.3892/etm.2010.182
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