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Article

Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer

  • Authors:
    • Hidehiro Tajima
    • Tetsuo Ohta
    • Hirohisa Kitagawa
    • Seisho Sakai
    • Isamu Makino
    • Hironori Hayashi
    • Katsunobu Oyama
    • Hisatoshi Nakagawara
    • Hideto Fujita
    • Ichiro Onishi
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Sachio Fushida
    • Takashi Tani
    • Takashi Fujimura
    • Wataru Koda
    • Tetsuya Minami
    • Yasuji Ryu
    • Junichiro Sanada
    • Toshifumi Gabata
    • Osamu Matsui
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterologic Surgery, Graduate School of Medicine Science, Kanazawa University, Kanazawa 920-8641, Japan, Department of Radiology, Graduate School of Medicine Science, Kanazawa University, Kanazawa 920-8641, Japan
  • Pages: 265-269
    |
    Published online on: January 12, 2011
       https://doi.org/10.3892/etm.2011.190
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Abstract

Hepatic metastasis is a common cause of treatment failure after curative resection of pancreatic cancer. We report a pilot study of hepatic arterial infusion (HAI) chemotherapy with gemcitabine and 5-fluorouracil (5-FU) for postoperative liver metastases from pancreatic cancer. Five patients who had undergone curative resection of liver metastases from pancreatic cancer received HAI of gemcitabine and 5-FU between October 2008 and September 2010 at Kanazawa University Hospital. Gemcitabine at a dose of 800 mg was infused over 30 min via a bedside pump. After gemcitabine administration, 250 mg of 5-FU was infused continuously over 24 h on days 1-5, comprising one cycle of therapy. These treatment cycles were continued biweekly. In the evaluation according to RECIST criteria, a partial response was obtained in 2 of the 5 cases, with stable disease being achieved in the remaining 3 cases (response rate, 100%). In 4 of the 5 cases, a decrease in serum tumor marker CA19-9 was observed after 10 HAI treatment cycles. The median time to treatment failure was 10 months (range 3-17). As to adverse events, leukocytopenia was grade 3 in 1 of 4 affected cases and all 5 were anemic, although 4 of the 5 cases had anemia prior to HAI therapy. Grade 2 thrombocytopenia was observed in 2 cases. No non-hematologic events, such as nausea, diarrhea, liver injury and neuropathy, occurred. There were no life-threatening toxicities, but 4 cases (80%) developed catheter complications, and the HAI catheter and subcutaneous implantable port system had to be removed. HAI delivers high doses of chemotherapeutic agents directly into tumor vessels, producing increased regional levels with greater efficacy and a lower incidence/severity of systemic side effects. In conclusion, HAI chemotherapy is useful and safe for the treatment of malignancies confined to the liver.
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Copy and paste a formatted citation
Spandidos Publications style
Tajima H, Ohta T, Kitagawa H, Sakai S, Makino I, Hayashi H, Oyama K, Nakagawara H, Fujita H, Onishi I, Onishi I, et al: Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer. Exp Ther Med 2: 265-269, 2011.
APA
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H. ... Matsui, O. (2011). Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer. Experimental and Therapeutic Medicine, 2, 265-269. https://doi.org/10.3892/etm.2011.190
MLA
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H., Oyama, K., Nakagawara, H., Fujita, H., Onishi, I., Takamura, H., Ninomiya, I., Fushida, S., Tani, T., Fujimura, T., Koda, W., Minami, T., Ryu, Y., Sanada, J., Gabata, T., Matsui, O."Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer". Experimental and Therapeutic Medicine 2.2 (2011): 265-269.
Chicago
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H., Oyama, K., Nakagawara, H., Fujita, H., Onishi, I., Takamura, H., Ninomiya, I., Fushida, S., Tani, T., Fujimura, T., Koda, W., Minami, T., Ryu, Y., Sanada, J., Gabata, T., Matsui, O."Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer". Experimental and Therapeutic Medicine 2, no. 2 (2011): 265-269. https://doi.org/10.3892/etm.2011.190
Copy and paste a formatted citation
x
Spandidos Publications style
Tajima H, Ohta T, Kitagawa H, Sakai S, Makino I, Hayashi H, Oyama K, Nakagawara H, Fujita H, Onishi I, Onishi I, et al: Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer. Exp Ther Med 2: 265-269, 2011.
APA
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H. ... Matsui, O. (2011). Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer. Experimental and Therapeutic Medicine, 2, 265-269. https://doi.org/10.3892/etm.2011.190
MLA
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H., Oyama, K., Nakagawara, H., Fujita, H., Onishi, I., Takamura, H., Ninomiya, I., Fushida, S., Tani, T., Fujimura, T., Koda, W., Minami, T., Ryu, Y., Sanada, J., Gabata, T., Matsui, O."Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer". Experimental and Therapeutic Medicine 2.2 (2011): 265-269.
Chicago
Tajima, H., Ohta, T., Kitagawa, H., Sakai, S., Makino, I., Hayashi, H., Oyama, K., Nakagawara, H., Fujita, H., Onishi, I., Takamura, H., Ninomiya, I., Fushida, S., Tani, T., Fujimura, T., Koda, W., Minami, T., Ryu, Y., Sanada, J., Gabata, T., Matsui, O."Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer". Experimental and Therapeutic Medicine 2, no. 2 (2011): 265-269. https://doi.org/10.3892/etm.2011.190
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