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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-April 2011 Volume 2 Issue 2

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Impact Factor: 2.3

Review

Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer (Review)

Zhicheng Ge, Andrew J. Sanders, Lin Ye, Wen G. Jiang
Pages: 167-172
Published online on: 20 January 2011

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Review

Maintenance therapy in ovarian cancer: Molecular basis and therapeutic approach (Review)

Monica Binaschi, Cecilia Simonelli, Cristina Goso, Mario Bigioni, Carlo Alberto Maggi
Pages: 173-180
Published online on: 14 January 2011

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Article

Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature

Digant Gupta, Pankaj G. Vashi, Kristen Trukova, Christopher G. Lis, Carolyn A. Lammersfeld
Pages: 181-193
Published online on: 20 January 2011

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Article Open Access

Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure

Kazuhiro Kotoh, Masaki Kato, Motoyuki Kohjima, Masatake Tanaka, Masayuki Miyazaki, Kazuhiko Nakamura, Munechika Enjoji, Makoto Nakamuta, Ryoichi Takayanagi
Pages: 195-199
Published online on: 19 January 2011

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Article Open Access

Whole rat DNA array survey for candidate genes related to hypertension in kidneys from three spontaneously hypertensive rat substrains at two stages of age and with hypotensive induction caused by hydralazine hydrochloride

Kosho Kinoshita, Mohammad Said Ashenagar, Masaki Tabuchi, Hideaki Higashino
Pages: 201-212
Published online on: 14 January 2011

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Article Open Access

Cyclin D1 predicts the prognosis of advanced serous ovarian cancer

Tomoko Hashimoto, Nozomu Yanaihara, Aikou Okamoto, Takashi Nikaido, Misato Saito, Satoshi Takakura, Makoto Yasuda, Hiroshi Sasaki, Kazunori Ochiai, Tadao Tanaka
Pages: 213-219
Published online on: 18 January 2011

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Article Open Access

Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence

Xi Zheng, Xiao-Xing Cui, Zhi Gao, Yang Zhao, Yi Shi, Mou-Tuan Huang, Yue Liu, George C. Wagner, Yong Lin, Weichung Joe Shih, Chinthalapally V. Rao, Chung S. Yang, Allan H. Conney
Pages: 221-228
Published online on: 20 January 2011

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Article Open Access

Heparanase modulates Shh and Wnt3a signaling in human medulloblastoma cells

Lon D. Ridgway, Michael D. Wetzel, Dario Marchetti
Pages: 229-237
Published online on: 28 December 2010

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Article

Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis

Yu Sato, Kensuke Kumamoto, Katsuharu Saito, Hirokazu Okayama, Suguru Hayase, Yasuhide Kofunato, Koutaro Miyamoto, Izumi Nakamura, Shinji Ohki, Yoshihisa Koyama, Seiichi Takenoshita
Pages: 239-243
Published online on: 20 January 2011

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Article

Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation/synthesis

Taiji Watari, Kiyohito Naito, Koji Sakamoto, Hisashi Kurosawa, Isao Nagaoka, Kazuo Kaneko
Pages: 245-250
Published online on: 19 January 2011

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Article

Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer

Mikito Inokuchi, Tadao Murayama, Mikiko Hayashi, Yoko Takagi, Keiji Kato, Megumu Enjoji, Kazuyuki Kojima, Jiro Kumagai, Kenichi Sugihara
Pages: 251-256
Published online on: 11 January 2011

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Article

Pathological tumor response to neoadjuvant chemotherapy using anthracycline and taxanes in patients with triple-negative breast cancer

Kaori Sakuma, Masafumi Kurosumi, Hanako Oba, Yasuhito Kobayashi, Hiroyuki Takei, Kenichi Inoue, Toshio Tabei, Tetsunari Oyama
Pages: 257-264
Published online on: 20 January 2011

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Article

Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer

Hidehiro Tajima, Tetsuo Ohta, Hirohisa Kitagawa, Seisho Sakai, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Hisatoshi Nakagawara, Hideto Fujita, Ichiro Onishi, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Takashi Tani, Takashi Fujimura, Wataru Koda, Tetsuya Minami, Yasuji Ryu, Junichiro Sanada, Toshifumi Gabata, Osamu Matsui
Pages: 265-269
Published online on: 12 January 2011

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Article

Decreased type III collagen expression in human uterine cervix of prolapse uteri

Masaaki Iwahashi, Yasuteru Muragaki
Pages: 271-274
Published online on: 20 January 2011

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Article

Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population

Guanghui Cheng, Hui Wang, Minzhi Chen, Li Li, Yaoqin Gong, Qiji Liu
Pages: 275-280
Published online on: 16 December 2010

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Article

Prostatic relaxation induced by loperamide is mediated through activation of opioid µ-2 receptors in vitro

Chih-Cheng Lu, Hsien-Hui Chung, Juei-Tang Cheng
Pages: 281-285
Published online on: 20 January 2011

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Article

Immunohistochemical analysis of collagen expression in uterine leiomyomata during the menstrual cycle

Masaaki Iwahashi, Yasuteru Muragaki, Makoto Ikoma, Yasushi Mabuchi, Aya Kobayashi, Yuuko Tanizaki, Kazuhiko Ino
Pages: 287-290
Published online on: 05 January 2011

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Article

Quality of life of lung cancer patients receiving outpatient chemotherapy

Ayako Matsuda, Mika Kobayashi, Yumi Sakakibara, Meiyo Tamaoka, Masashi Furuiye, Naohiko Inase, Eisuke Matsushima
Pages: 291-294
Published online on: 05 January 2011

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Article

High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma

J. Brunotte, H. C. Bock, W. Brück, B. Hemmerlein, H. Strik
Pages: 295-299
Published online on: 19 January 2011

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Article

Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro

Christoph W. Strey, Lea Schamell, Elsie Oppermann, Axel Haferkamp, Wolf O. Bechstein, Roman A. Blaheta
Pages: 301-307
Published online on: 20 January 2011

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Article

Enhanced peroxisomal β-oxidation metabolism in visceral adipose tissues of high-fat diet-fed obesity-resistant C57BL/6 mice

Wei-Dong Xie, Hua Wang, Jin-Fang Zhang, Jian-Na Li, Yi Can, Lv Qing, Hsiang-Fu Kung, Ya-Ou Zhang
Pages: 309-315
Published online on: 20 January 2011

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Article

Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer

Vidudala V.T.S. Prasad, Padma Kolli, Divya Moganti
Pages: 317-323
Published online on: 20 January 2011

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Article

Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus

Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
Pages: 325-331
Published online on: 13 January 2011

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Article

Effects of peripherally administered urocortin 3 on feeding behavior and gastric emptying in mice

Mutsumi Terashi, Akihiro Asakawa, Kai-Chun Cheng, Ken-Ichiro Koyama, Huke Chaolu, Miharu Ushikai, Akio Inui
Pages: 333-335
Published online on: 20 January 2011

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Article

Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy

Jin-Soon Suh, Won-Ho Hahn, Jong Seok Lee, Hae Jeong Park, Mi-Ja Kim, Sung Wook Kang, Joo-Ho Chung, Byoung-Soo Cho
Pages: 337-341
Published online on: 18 January 2011

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Article

Metronomic treatment of temozolomide increases anti-angiogenicity accompanied by down-regulated O6-methylguanine-DNA methyltransferase expression in endothelial cells

Kyung-Kon Ko, Eun-Sang Lee, Young Ae Joe, Yong-Kil Hong
Pages: 343-348
Published online on: 20 January 2011

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Article

Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility

Francieli Delongui, Cíntia Magalhães Carvalho Grion, Maria Angelica Ehara Watanabe, Helena Kaminami Morimoto, Ana Maria Bonametti, Julie Massayo Maeda Oda, Ana Paula Kallaur, Tiemi Matsuo, Edna Maria Vissoci Reiche
Pages: 349-356
Published online on: 20 January 2011

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Article

Reduction of matrix metalloproteinase-9 expression by culture filtrate of Paecilomyces farinosus J3

Hyun-Jin Lee, Chul-Hong Park, Hyung-U Son, Jin-Chul Heo, Sung-Hee Nam, Kwang-Gil Lee, Joo-Hong Yeo, Cheol-Sik Yoon, Jong-Myeung Kim, Yong-Kyu Shin, Si-Oh Kim, Sang-Han Lee
Pages: 357-362
Published online on: 20 January 2011

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Article

Low molecular weight heparin suppresses tissue factor-mediated cancer cell invasion and migration in vitro

Camille Ettelaie, Donna Fountain, Mary-Elizabeth W. Collier, Ellie Beeby, Yu Pei Xiao, Anthony Maraveyas
Pages: 363-367
Published online on: 20 January 2011

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Article

Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

Huhe Chaolu, Akihiro Asakawa, Miharu Ushikai, Ying-Xiao Li, Kai-Chun Cheng, Jiang-Bo Li, Takahiro Zoshiki, Mutsumi Terashi, Chie Tanaka, Kaori Atsuchi, Takeo Sakoguchi, Minglun Tsai, Haruka Amitani, Masahisa Horiuchi, Toru Takeuchi, Akio Inui
Pages: 369-373
Published online on: 19 January 2011

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Journal Cover
May-2026 Volume 31 Issue 5

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Impact Factor: 2.3

Review Open Access

FCER1G: A multifunctional regulator in the immune microenvironment (Review)

Yuyu Zhang, Jinglan Wang, Wenting He, Tao Liu
Article Number: 146
Published online on: 26 March 2026

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Article Open Access

A nomogram for predicting recurrence‑free survival in patients with high‑risk GIST receiving adjuvant imatinib: A nationwide registry study

Chun-Nan Yeh, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai, Chuan-Cheng Wang, Ming-Tsan Lin, Chun-Fu Ting, De-Chuan Chan, Te-Hung Chen, Chueh-Chuan Yen, Yen-Yang Chen, Hsuan-Yu Lin, Ta-Sen Yeh, Ching-Liang Ho, Tze-Yu Shieh, Li-Yaun Bai, Jun-Te Hsu, I-Shu Chen, Li-Tzong Chen, Hui-Jen Tsai, The Taiwan Cooperative Oncology Group Gist Study Group
Article Number: 145
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] MicroRNA‑18a‑5p represses scar fibroblast proliferation and extracellular matrix deposition through regulating Smad2 expression

Tianshi Li, Yiguang Wu, Dandan Liu, Lida Zhuang
Article Number: 144
Published online on: 23 March 2026

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Article

Risk factors for severe retinopathy of prematurity: A retrospective case‑control study

Qingmin Ma, Xi Lv, Jiangya Wang, Kejun Li, Wenwen Τang
Article Number: 143
Published online on: 20 March 2026

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Article Open Access

Atorvastatin augments collateral formation and functional recovery after indirect revascularization in adult ischemic moyamoya disease: A randomized trial

Dawei Wang, Jingya Dai, Shumei Li, Yaping Liu, Xiaofeng Xing, Lei Huang, Qijun Pang
Article Number: 142
Published online on: 19 March 2026

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Article Open Access

Maresin 1 activates autophagy through SIRT1/PPAR‑γ signaling to mitigate high glucose‑induced pyroptosis in human retinal pigment epithelial cells

Jun Zhang, Ding Zhao, Yuanqing Zhang, Haoxiang Sun, Zhipeng Yan, Haiyan Sun
Article Number: 141
Published online on: 19 March 2026

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Review Open Access

Advances in new ultrasound technologies in targeted prostate biopsy (Review)

Tingting Jin, Liying Wang, Shusen Zheng
Article Number: 140
Published online on: 19 March 2026

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Review Open Access

Immune cross talk and therapeutic advances in lactate metabolism in the tumor microenvironment (Review)

Min Liu, Kui Su
Article Number: 139
Published online on: 19 March 2026

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Article Open Access

Immunohistochemical evaluation of gastric‑type markers in primary extramammary Paget disease: Differential MUC5AC expression between in situ and invasive lesions

Naoto Kohno, Mitsuaki Ishida, Shizuka Ono, Yoshinobu Hirose
Article Number: 138
Published online on: 19 March 2026

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Review Open Access

Disrupted beginnings: Neurodevelopmental outcomes of COVID‑19 lockdowns in early childhood (Review)

Ioanna Giannopoulou, Vasiliki Efstathiou, Maria-Ioanna Stefanou, Panagiota Korkoliakou, James N. Tsoporis, Demetrios A. Spandidos, Emmanouil Rizos
Article Number: 137
Published online on: 16 March 2026

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Retraction Open Access

[Retracted] Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF‑κB and PI3K/AKT pathways

Ling Sun, Jing Zhang
Article Number: 136
Published online on: 16 March 2026

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Article Open Access

Effects of fullerenol C60 on the liver, heart and brain tissues of streptozotocin‑induced diabetic rats with sepsis

Necmiye Şengel, Ömer Kubat, Laman Farajsoylu, Ahmet Çağri Büyükkasap, Muharrem Atli, Şaban Cem Sezen, Hasan Bostanci, Kürşat Dikmen, Işin Güneş, Fatma Er, Mustafa Kavutçu, Mustafa Arslan
Article Number: 135
Published online on: 13 March 2026

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Article Open Access

Long non‑coding RNA KCNQ1OT1 promotes ovarian cancer cell malignant characteristics by targeting the miR‑140‑5p/KLK10 axis

Renjie Duan, Zhenyu Tao, Shun Tao, Aichen Yang, Xu Yang, Changzheng Li, Xiaoxiang Zhu, Kexin Zhang, Zhuofu Li, Shanjun Tao
Article Number: 134
Published online on: 11 March 2026

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Article

Deciphering the dynamics of the splenium: A comprehensive analysis of flair hyperintensity variations

Ezel Yaltirik Bilgin, Özkan Ünal, Yasin Özdemir, Onur Şimşek
Article Number: 133
Published online on: 09 March 2026

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Article Open Access

Prior curative‑intent treatment strategy affects progression outcomes of first‑line immunotherapy in metastatic non‑small cell lung cancer: A retrospective cohort study

Ruhper Cekin, Didar Senocak, Serdar Arici, Alpaslan Ozgun
Article Number: 132
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Recent perspectives of electronic medical record systems (Review)

Xiao-Ying Zhang, Peiying Zhang
Article Number: 131
Published online on: 09 March 2026

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Case Report Open Access

Direct venous‑to‑arterial communication as a novel mechanism for ectopic embolism following esophageal variceal embolization: A case report

Youchun Lei, You Ke, Tianwen Yang, Zhengguo Xu
Article Number: 130
Published online on: 06 March 2026

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Case Report

Diagnostic and therapeutic challenges of isolated spinal vasculitis: A case report

Yajun Yao, Ge-Hong Dong, De-Cai Tian
Article Number: 129
Published online on: 06 March 2026

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Article Open Access

Impact of older age on prognosis in hypersensitivity pneumonitis: A systematic review and meta‑analysis

Konstantinos Dodos, Tsampika-Vasileia Kalamara, Vasiliki Therapioti‑Mavroudi, Nikolaos Trakas, Eleni Sklapani, Demetrios A. Spandidos, Alexandru Corlateanu, Vasiliki Epameinondas Georgakopoulou
Article Number: 128
Published online on: 06 March 2026

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Article

Anti‑inflammatory effects of oridonin on an in vitro model using LPS‑treated human intestinal Caco‑2 cells

Maonan Wang, Bo Xu, Linyue Li, Yu Wang, Mingcheng Li
Article Number: 127
Published online on: 03 March 2026

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Case Report

Management after two consecutive suction losses during small‑incision lenticule extraction: A case report

Luanying Wei, Tiantian Qi, Nan Li, Qiang Shi, Shengjian Mi, Cheng Pei
Article Number: 126
Published online on: 03 March 2026

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Case Report Open Access

Hematemesis resulting from mesenteric venous thrombosis: A case report

Chunyu Shi, Zhongmin Li, Lu Pan, Bin Song
Article Number: 125
Published online on: 02 March 2026

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Article

Inhibitory effects of spermidine on lipopolysaccharide‑induced inflammation in RAW 264.7 cells

Hao Yuan, Fang Peng, Yi-Feng Zhou, Si-Xian Wu, Zhen-Yi Long, Ya-Meng Peng, Yi-Zhao Zhou
Article Number: 124
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Telemedicine in clinical setting (Review)

Xiao-Ying Zhang, Peiying Zhang
Article Number: 123
Published online on: 02 March 2026

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Article

Effects of spironolactone on cytotoxic damage in osteoblasts

So Young Park, Kwang Sik Suh, Hyun-Sook Kim, Soo Jin Yun, Hyunji Sang, Sang Ouk Chin
Article Number: 122
Published online on: 27 February 2026

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Article Open Access

RNU2‑1 gene copy number variations do not affect serum levels of miR‑1246 as a biomarker for lung adenocarcinoma

Makiko Ueda, Shinya Sato, Yohei Miyagi, Toshiko Aiso
Article Number: 121
Published online on: 27 February 2026

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Article Open Access

A laboratory micro‑CT technique is useful to visualize and characterize dermal skin components in a 3D manner

Katarina Lundqvist, Hanna Tufvesson, Lars B. Dahlin, Marius Reichardt, Bodil Ohlsson
Article Number: 120
Published online on: 27 February 2026

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Case Report

A rare case of early‑onset cerebral syphilitic gummata with severe neurological decline in early‑stage syphilis: A case report

Yujie Ji, Shelin Liu, Yunwei Wang, Youcai Zhao, Zheng Cai, Bing Li
Article Number: 119
Published online on: 26 February 2026

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Review Open Access

Organelle homeostasis disruption: A driving force in the progression of cardiomyopathy (Review)

Yuxing Hou, Chao Li, Youyou Chen, Danfeng Zhong, Miaomiao Chai, Lijiao Mo, Senna Lin, Fangfang Huang, Qi Chen
Article Number: 118
Published online on: 26 February 2026

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June-2026 Volume 31 Issue 6

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Article Open Access

Multi‑omics analysis of glutamine and fish collagen peptides in alleviating post‑antibiotic Streptococcus pneumoniae injury in feline lung cells

Huasong Bai, Tong Liu, Hengyan Wang, Hongchen Jin, Yunliang Li, Zhanzhong Wang
Article Number: 148
Published online on: 30 March 2026

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Retraction Open Access

[Retracted] MicroRNA‑1236‑3p/translationally controlled tumor protein (TPT1) axis participates in congenital hypothyroidism progression by regulating neuronal apoptosis

Tingting Meng, Shiman Shen, Cheng Li, Xuehua Liu
Article Number: 147
Published online on: 30 March 2026

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