Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus

Yoshida,Tetsuro; Kato,Kimihiko; Oguri,Mitsutoshi; Horibe,Hideki; Kawamiya,Toshiki; Yokoi,Kiyoshi; Fujimaki,Tetsuo; Watanabe,Sachiro; Satoh,Kei; Aoyagi,Yukitoshi; Tanaka,Masashi; Yoshida,Hiroto; Shinkai,Shoji; Nozawa,Yoshinori; Yamada,Yoshiji

doi:10.3892/etm.2011.191

Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus

Authors:
- Tetsuro Yoshida
- Kimihiko Kato
- Mitsutoshi Oguri
- Hideki Horibe
- Toshiki Kawamiya
- Kiyoshi Yokoi
- Tetsuo Fujimaki
- Sachiro Watanabe
- Kei Satoh
- Yukitoshi Aoyagi
- Masashi Tanaka
- Hiroto Yoshida
- Shoji Shinkai
- Yoshinori Nozawa
- Yoshiji Yamada
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Affiliations: Department of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Onga, Japan, Meitoh Hospital, Nagoya, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan, Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Gifu International Institute of Biotechnology and Tokai Gakuin University, Kakamigahara, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
Published online on: January 13, 2011 https://doi.org/10.3892/etm.2011.191
Pages: 325-331

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Abstract

Hypertension and diabetes mellitus are important risk factors for chronic kidney disease (CKD). We previously showed that the C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with myocardial infarction. The purpose of the present study was to examine an association of rs6929846 of BTN2A1 with CKD in individuals with or without hypertension or diabetes mellitus, thereby contributing to the personalized prevention of CKD in such individuals separately. The study population comprised 7,542 unrelated individuals, including 2,289 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2] and 5,253 controls (eGFR ≥60 ml/min/1.73 m2) with or without hypertension or diabetes mellitus. The Chi-square test, a multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that the C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with CKD in normotensive individuals, in diabetic individuals and in individuals with hypertension and diabetes mellitus, or without either condition, with the T allele representing a risk factor for CKD. Stratification of subjects based on hypertension or diabetes mellitus may thus be important in order to achieve personalized prevention of CKD with the use of genetic information.

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