Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

Chaolu,Huhe; Asakawa,Akihiro; Ushikai,Miharu; Li,Ying-Xiao; Cheng,Kai-Chun; Li,Jiang-Bo; Zoshiki,Takahiro; Terashi,Mutsumi; Tanaka,Chie; Atsuchi,Kaori; Sakoguchi,Takeo; Tsai,Minglun; Amitani,Haruka; Horiuchi,Masahisa; Takeuchi,Toru; Inui,Akio

doi:10.3892/etm.2011.199

March-April 2011 Volume 2 Issue 2

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March-April 2011 Volume 2 Issue 2

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Article

Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

Authors:
- Huhe Chaolu
- Akihiro Asakawa
- Miharu Ushikai
- Ying-Xiao Li
- Kai-Chun Cheng
- Jiang-Bo Li
- Takahiro Zoshiki
- Mutsumi Terashi
- Chie Tanaka
- Kaori Atsuchi
- Takeo Sakoguchi
- Minglun Tsai
- Haruka Amitani
- Masahisa Horiuchi
- Toru Takeuchi
- Akio Inui
View Affiliations / Copyright

Affiliations: Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Division of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Division of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan
Pages: 369-373
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Published online on: January 19, 2011

https://doi.org/10.3892/etm.2011.199
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Abstract

Lifestyle-related diseases are associated with overeating and lack of exercise. The purpose of this study was to investigate the effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels. Mice were housed for 4 weeks in 4 groups, which included the non-exercise and normal diet (SN), exercise and normal diet (EN), non-exercise and high-fat diet (SF) and the exercise and high-fat diet (EF) group. The mice in the exercise groups were housed in cages with a running wheel and were subjected to voluntary exercise. The food intake (Kcal) of the mice in the exercise groups increased compared to that of the mice in the non-exercise groups (P<0.01). Body weight and visceral fat decreased in the mice in the EF group compared to the mice in the SF group (P<0.01 and P<0.05). The temperature of the mice in the EF group increased compared to that of the mice in the SN group (P<0.05). Blood glucose, insulin (P<0.01), cholesterol (P<0.01) and triglyceride concentrations (P<0.01) increased in the SF group compared to the normal diet groups. Furthermore, plasma insulin and cholesterol concentrations increased in the SF group compared to the exercise groups (P<0.01). Plasma adiponectin and nesfatin-1 levels in the SF group decreased compared to the SN group (P<0.05). Exercise under a high-fat diet antagonized the significant decrease in the nesfatin-1 level. Exercise together with a high-fat diet affected the plasma levels of adiponectin and nesfatin. It is therefore suggested that exercise together with a high-fat diet can affect various diseases via adiponectin and nesfatin.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

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