Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-April 2011 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2011 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility

  • Authors:
    • Francieli Delongui
    • Cíntia Magalhães Carvalho Grion
    • Maria Angelica Ehara Watanabe
    • Helena Kaminami Morimoto
    • Ana Maria Bonametti
    • Julie Massayo Maeda Oda
    • Ana Paula Kallaur
    • Tiemi Matsuo
    • Edna Maria Vissoci Reiche
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Clinical Analysis and Toxicology, Health Sciences Center, Londrina State University, CEP 86.038-440, Londrina, Paraná, Brazil, Department of Clinical Medicine, Health Sciences Center, University Hospital, Londrina State University, CEP 86.038-440, Londrina, Paraná, Brazil, Molecular Genetic Laboratory, Biological Sciences Center, Londrina State University, CEP 86.038-440, Londrina, Paraná, Brazil, Department of Biostatistics, Exacts Sciences Center, Londrina State University, Londrina, Paraná, Brazil
  • Pages: 349-356
    |
    Published online on: January 20, 2011
       https://doi.org/10.3892/etm.2011.213
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The association of the tumor necrosis factor β (TNF-β) Nco1 genetic polymorphism with susceptibility to sepsis was evaluated in 60 consecutive patients diagnosed with sepsis and in 148 healthy blood donors. Genomic DNA was extracted from peripheral blood cells and a 782 base-pair fragment of the TNF-β gene was amplified by PCR. The PCR products were subjected to Nco1 restriction digestion and analysed by restriction fragment length polymorphism analysis. Tumor necrosis factor α (TNF-α) and the C-reactive protein (CRP) serum levels were also determined by ELISA and nephelometry, respectively. Among the septic patients, the allelic frequencies of TNFB1 and TNFB2 were 0.2833 and 0.7166, respectively, and they differed from those observed in the blood donors (p=0.0282). The TNFB2 allele frequency was higher in the septic patients than in the blood donors [odds ratio=1.65 (CI 95% 1.02-2.69), p=0.0315]. The TNF-α and CRP serum levels and the APACHE II and SOFA clinical scores did not differ in the patients with the TNFB1 or TNFB2 alleles (p>0.05). The results suggest that the TNFB2 allele is associated with susceptibility to sepsis, but it was not found to be associated with the immunological and clinical biomarkers of the disease.
View Figures
View References

1. 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

2. 

Brun-Buisson C, Doyon F, Carlet J, et al: Incidence, risk factors, and outcome of severe sepsis study in intensive care units. A multicenter prospective study in intensive care units. JAMA. 274:968–974. 1995. View Article : Google Scholar : PubMed/NCBI

3. 

Levy MM, Fink MP, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 31:1250–1256. 2003. View Article : Google Scholar : PubMed/NCBI

4. 

Waterer GW and Wunderink RG: Science review: genetic variability in the systematic inflammatory response. Crit Care. 7:308–314. 2003. View Article : Google Scholar : PubMed/NCBI

5. 

Sorensen TI, Nielsenm GG, Andersen PK and Teasdale TW: Genetic and environmental influences on premature death in adult adoptees. N Engl J Med. 318:727–732. 1988. View Article : Google Scholar : PubMed/NCBI

6. 

Eigler A, Sinha B, Hartmann G and Endres S: Taming TNF: strategies to restrain this proinflammatory cytokine. Immunology Today. 18:487–492. 1997. View Article : Google Scholar : PubMed/NCBI

7. 

Zhang D-L, Li J-S, Jiang Z-W, Yu B-J, Tang X-M and Zheng H-M: Association of two polymorphism of tumor necrosis factor gene with acute biliary pancreatitis. World J Gastroenterol. 9:824–828. 2003.PubMed/NCBI

8. 

Holmes CL, Russell JA and Walley KR: Genetic polymorphisms in sepse and septic shock-role in prognosis and potencial for therapy. Chest. 124:1103–1115. 2003. View Article : Google Scholar : PubMed/NCBI

9. 

Messer G, Spengler U, Jung MC, et al: Polymorphic structure of the tumor necrosis factor (TNF) locus: an Nco1 polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 173:209–219. 1991. View Article : Google Scholar

10. 

Stuber F, Petersen M, Bokelmann F and Schade U: A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis. Crit Care Med. 24:381–384. 1996.

11. 

Majetschak M, Flohé S, Obertacke U, et al: Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg. 203:207–214. 1999. View Article : Google Scholar : PubMed/NCBI

12. 

Majetschak M, Obertacke U, Schade FU, et al: Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients. Clin Diagn Lab Immunol. 9:1205–1211. 2002.PubMed/NCBI

13. 

Knaus WA, Zimmermann JE, Wagner DP, Draper EA and Laurence DE: APACHE – acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med. 9:591–597. 1981.

14. 

Ferreira FL, Bota DP, Bross A, Mélt C and Vincent JL: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 286:1754–1758. 2001. View Article : Google Scholar : PubMed/NCBI

15. 

Miller AS, Dykes DD and Polesky HS: A simple salting out procedure for extraction DNA from human nucleated cells. Nucleic Acid Res. 16:1215–1219. 1988. View Article : Google Scholar : PubMed/NCBI

16. 

Reiche EMV, Bonametti AM, Watanabe MAE, et al: Socio-demographic and epidemiological characteristics associated with human immunodeficiency virus type 1 (HIV-1) infection in HIV-1-exposed but uninfected individuals, and in HIV-1-infected patients from a southern Brazilian population. Rev Inst Med Trop Sao Paulo. 47:239–246. 2005. View Article : Google Scholar

17. 

Dean AG, Dean JA, Coulombier D, Brendel KA, Smith DC and Burton H: Epi Info, Version 6: a Word-Processing Database, and Statistics Program for Public Health on IBM-Compatible Microcomputers. Centers for Disease Control and Prevention, Atlanta, GA, USA. 1995.

18. 

SAS Institute Inc: SAS/STAT User's Guide, Version 6. Fourth Edition. SAS Institute Inc; Cary, NC: 1989

19. 

Sutherland AM and Russell JA: Issues with polymorphism analysis in sepsis. Clin Infect Dis. 41:S396–S402. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Waterer GW, Quasney MW, Cantor RM, et al: Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am J Respir Crit Care Med. 163:1599–1604. 2001. View Article : Google Scholar : PubMed/NCBI

21. 

Degoricija V, Sharma M, Legac A, Gradiser M, Sefer S and Vucicevic Z: Survival analysis of 314 episodes of sepsis in medical intensive care unit in University Hospital: impact of intensive care unit performance and antimicrobial therapy. Croat Med J. 47:385–397. 2006.PubMed/NCBI

22. 

Brun-Buisson C, Meshaka P and Pinton P; Vallet B; EPISEPSIS Study Group: EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med. 30:580–588. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Esteban A, Frutos-Vivar F, Ferguson ND, et al: Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med. 35:1284–1289. 2007. View Article : Google Scholar : PubMed/NCBI

24. 

Mikawa AY, Tagliavini SA and Costa PI: CCR5 genotype and plasma β-chemokine concentration of Brazilian HIV-infected individuals. Braz J Med Biol Res. 35:1333–1337. 2002.

25. 

Ribeiro MA: Levels of C-reactive protein in serum samples from healthy children and adults in São Paulo, Brazil. Braz J Med Biol Res. 30:1055–1059. 1997.PubMed/NCBI

26. 

Povoa P, Almeida E, Moreira P, et al: C-reactive protein as an indicator of sepsis. Intensive Care Med. 24:1052–1056. 1998. View Article : Google Scholar : PubMed/NCBI

27. 

Westendorp RGJ, Langermans JAM, Huizinga TWJ, Verweij CL and Sturk A: Genetic influence on cytokine production and fatal meningococcal disease. Lancet. 349:170–173. 1997. View Article : Google Scholar : PubMed/NCBI

28. 

Van der Linden MW, Huizinga TW, Stoeken DJ, Sturk A and Westerndorp RG: Determination of tumor necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation. J Immunol Methods. 218:63–71. 1998.

29. 

Yan M, Zhao L, Zheng F, Sun X, Zhang Y and Wang C: The relationship between gene polymorphism and CRP level in a Chinese Han population. Biochem Genet. 45:1–9. 2007. View Article : Google Scholar : PubMed/NCBI

30. 

Danik JS and Ridker PM: Genetic determinants of C-reactive protein. Curr Atheroscler Rep. 9:195–203. 2007. View Article : Google Scholar

31. 

Martinez-Calatrava MJ, González-Sanches JL, Martinez-Larrad MT, Pérez-Barba M and Serrano-Ríos M: Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study Thromb Haemost. 98:1088–1095. 2007.

32. 

Posch PE, Cruz I, Bradshaw D and Medhekar BA: Novel polymorphisms and the definition of promoter alleles of the tumor necrosis factor and lymphotoxin α loci: inclusion in HLA haplotypes. Genes and Immunity. 4:547–558. 2003.PubMed/NCBI

33. 

Tsytsykova AV, Rajsbaum R, Falvo JV, Ligeiro F, Neely SR and Goldfeld AE: Activation-dependent intrachromosomal interactions formed by the TNF gene promoter and two distal enhancers. PNAS. 23:16850–16855. 2007. View Article : Google Scholar : PubMed/NCBI

34. 

Kaufmann P, Tilz GP, Lueger A and Demel U: Elevated plasma levels of soluble tumor necrosis factor receptor (sTNFp60) reflect severity of acute pancreatitis. Intensive Care Med. 23:841–848. 2007. View Article : Google Scholar : PubMed/NCBI

35. 

Dhainaut JF, Vincent JL, Richard C, et al: CDP571, a humanized antibody to human tumor necrosis factor-alpha: safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. Crit Care Med. 23:1461–1469. 1995. View Article : Google Scholar

36. 

Aggarval BB and Natarajan K: Tumor necrosis factors: developments during the last decade. Eur Cytokine Netw. 7:93–124. 1996.PubMed/NCBI

37. 

Keel M, Ercknauer E, Stocker R, et al: Different pattern of local and systemic release of proinflammatory and anti-inflammatory mediators in severely injured patients with chest trauma. J Trauma. 40:907–912. 1996. View Article : Google Scholar : PubMed/NCBI

38. 

Andrejko KM and Deutschman CS: Acute-phase gene expression correlates with intrahepatic tumor necrosis factor alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflammatory response syndrome in the rat. Crit Care Med. 24:1947–1952. 1996. View Article : Google Scholar

39. 

Pellegrini JD, Puyana JC, Lapchak PH, Kodys K and Millergraziano CL: A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality. Shock. 6:389–396. 1996. View Article : Google Scholar : PubMed/NCBI

40. 

Bagby GJ, Plessala KL, Wilson LA, Thompson JJ and Nelson S: Divergent efficiency of antibody to tumor necrosis factor-α intravascular and peritonitis model of sepsis. J Infect Dis. 163:83–88. 1991.

41. 

Wakabayashi G, Gelfand JA, Jung WK, Connoly RJ, Burke JF and Dinarello CA: Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia: comparison to Escherichia coli. J Clin Invest. 87:1925–1935. 1991. View Article : Google Scholar

42. 

Kurt AN, Aygun AD, Godekmerdn A, Kurt A, Dogan Y and Yilmaz E: Serum IL-1β, IL-6, IL-8, and TNF-α levels in early diagnosis and management of neonatal sepsis. Mediators Inflamm. 31397:2007 View Article : Google Scholar

43. 

Bont ES, Martens A, van Raan J, Samson G, Fetter WP, Okken A and de Leij LH: Tumor necrosis factor-α, interleukin-β, and interleukin-6 plasma levels in neonatal sepsis. Pediatr Res. 33:380–383. 1993.

44. 

Ozdemir A, Oygur N, Gultekin M, Coskun M and Yegin O: Neonatal tumor necrosis factor, interleukin-1α, interleukin-1β, and interleukin-6 response to infection. Am J Perinatol. 11:282–285. 1994.

45. 

Miller LC, Isa S, LoPreste G, Schaller JG and Dinarello CA: Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production. J Pediatr. 117:961–965. 1990.

46. 

Edgar JDM, Wilson DC and McMillan SA: Predictive value of soluble immunological mediators in neonatal infection. Clin Sci. 87:165–171. 1994.PubMed/NCBI

47. 

Santana Reyes C, García-Muñoz F, Reyes D, González G, Dominguez C and Domenech E: Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis. Acta Paediatr. 92:221–227. 2003.PubMed/NCBI

48. 

Kahlke V, Schafmayer C, Schniewind B, Seegert D, Schreiber S and Schröder J: Are postoperative complications genetically determined by TNF-β NcoI gene polymorphism? Surgery. 135:365–373. 2004.

49. 

Garnacho-Montero J, Aldabo-Pallas T, Garnacho-Montero C, Cayuela A, Jiménez R, Barroso S and Ortiz-Leyba C: Timing of adequate antibiotic therapy is a greater determinant of outcome that are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care. 10:R1112006. View Article : Google Scholar : PubMed/NCBI

50. 

Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ and Hutchinson IV: An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 24:1–8. 1997. View Article : Google Scholar : PubMed/NCBI

51. 

Fang XM, Schroder S, Hoeft A and Stuber F: Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med. 27:1330–1334. 1999. View Article : Google Scholar : PubMed/NCBI

52. 

Danis VA, Millington M, Hyland VJ and Grennan D: Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol. 99:303–310. 1995. View Article : Google Scholar : PubMed/NCBI

53. 

Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S and Woo P: The effect of novel polymorphism in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and as association with systemic-onset juveline chronic arthritis. J Clin Invest. 102:1369–1376. 1998. View Article : Google Scholar : PubMed/NCBI

54. 

Barber RF, Chang LY, Arnoldo BD, Purdue GF, Hunt JL, Horton JW and Aragaki CC: Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res. 4:250–255. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Delongui F, Carvalho Grion CM, Ehara Watanabe MA, Kaminami Morimoto H, Bonametti AM, Maeda Oda JM, Kallaur AP, Matsuo T and Vissoci Reiche EM: Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. Exp Ther Med 2: 349-356, 2011.
APA
Delongui, F., Carvalho Grion, C.M., Ehara Watanabe, M.A., Kaminami Morimoto, H., Bonametti, A.M., Maeda Oda, J.M. ... Vissoci Reiche, E.M. (2011). Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. Experimental and Therapeutic Medicine, 2, 349-356. https://doi.org/10.3892/etm.2011.213
MLA
Delongui, F., Carvalho Grion, C. M., Ehara Watanabe, M. A., Kaminami Morimoto, H., Bonametti, A. M., Maeda Oda, J. M., Kallaur, A. P., Matsuo, T., Vissoci Reiche, E. M."Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility". Experimental and Therapeutic Medicine 2.2 (2011): 349-356.
Chicago
Delongui, F., Carvalho Grion, C. M., Ehara Watanabe, M. A., Kaminami Morimoto, H., Bonametti, A. M., Maeda Oda, J. M., Kallaur, A. P., Matsuo, T., Vissoci Reiche, E. M."Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility". Experimental and Therapeutic Medicine 2, no. 2 (2011): 349-356. https://doi.org/10.3892/etm.2011.213
Copy and paste a formatted citation
x
Spandidos Publications style
Delongui F, Carvalho Grion CM, Ehara Watanabe MA, Kaminami Morimoto H, Bonametti AM, Maeda Oda JM, Kallaur AP, Matsuo T and Vissoci Reiche EM: Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. Exp Ther Med 2: 349-356, 2011.
APA
Delongui, F., Carvalho Grion, C.M., Ehara Watanabe, M.A., Kaminami Morimoto, H., Bonametti, A.M., Maeda Oda, J.M. ... Vissoci Reiche, E.M. (2011). Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. Experimental and Therapeutic Medicine, 2, 349-356. https://doi.org/10.3892/etm.2011.213
MLA
Delongui, F., Carvalho Grion, C. M., Ehara Watanabe, M. A., Kaminami Morimoto, H., Bonametti, A. M., Maeda Oda, J. M., Kallaur, A. P., Matsuo, T., Vissoci Reiche, E. M."Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility". Experimental and Therapeutic Medicine 2.2 (2011): 349-356.
Chicago
Delongui, F., Carvalho Grion, C. M., Ehara Watanabe, M. A., Kaminami Morimoto, H., Bonametti, A. M., Maeda Oda, J. M., Kallaur, A. P., Matsuo, T., Vissoci Reiche, E. M."Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility". Experimental and Therapeutic Medicine 2, no. 2 (2011): 349-356. https://doi.org/10.3892/etm.2011.213
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team