Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma

Imashimizu,Kohta; Shiomi,Kazu; Maeda,Masahiro; Aoki,Naoko; Igarashi,Kiyoko; Suzuki,Fumio; Koizumi,Mitsuru; Suzuki,Kenji; Hino,Okio

doi:10.3892/etm.2011.225

May-June 2011 Volume 2 Issue 3

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May-June 2011 Volume 2 Issue 3

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Article

Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma

Authors:
- Kohta Imashimizu
- Kazu Shiomi
- Masahiro Maeda
- Naoko Aoki
- Kiyoko Igarashi
- Fumio Suzuki
- Mitsuru Koizumi
- Kenji Suzuki
- Okio Hino
View Affiliations / Copyright

Affiliations: Department of General Thoracic Surgery, Respiratory Medicine, Human Pathology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan, Immuno-Biological Laboratories, Co., Ltd., Fujioka-shi, Gunma 375-0005, Japan, Department of Pathology and Oncology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan, Environmental Carcinogenesis Research Center, Itabashi-ku, Tokyo 173-0025, Japan, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan
Pages: 409-411
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Published online on: March 8, 2011

https://doi.org/10.3892/etm.2011.225
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Abstract

A large-scale screening involving the measurement of N-ERC/mesothelin levels in blood using an ELISA system for the early diagnosis of malignant mesothelioma (MM) was carried out in individuals with a history of employment at construction sites. Approximately 30,000 subjects were screened. Of the 80 subjects with high-risk values, one male patient was diagnosed as having MM based on a PET study and histopathology. This is the first report of the pre-clinical diagnosis of MM based on blood test screening. In addition, plasma levels of N-ERC/mesothelin may be effectively used for monitoring relapse after surgery.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma

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