Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma

Retraction in: /10.3892/etm.2016.3171

  • Authors:
    • Kai Shen
    • Yong Ji
    • Guo-Qiang Chen
    • Bin Huang
    • Xian Zhang
    • Song Wu
    • Gui-Ping Yu
    • Xiao-Chen Wang
  • View Affiliations

  • Published online on: July 20, 2011     https://doi.org/10.3892/etm.2011.320
  • Pages: 1117-1120
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Abstract

MYH is an important enzyme in combating DNA oxidative stress in the occurrence and development of various types of tumors. To investigate the correlation between expression of the DNA repair enzyme MYH in esophageal squamous cell carcinoma and 8-oxoguanine (8-oxoG) oxidative damage, as well as the clinical significance of altered MYH expression, tissues from 175 esophageal carcinoma cases were investigated in the present study. MYH expression and 8-oxoG oxidative damage in squamous cell carcinoma and adjacent normal tissue were assessed by immunohistochemistry and Western blotting. In 82.9% (145/175) of the cases, MYH protein expression in esophageal squamous cell carcinoma was lower than that of adjacent normal tissue (t=4.24, P<0.001). Additionally, 8-oxoG staining was higher in the tumors than in the normal tissue. Lower expression of MYH in esophageal squamous cell carcinoma was associated with depth of invasion, venous invasion, TNM stage and lymph node metastasis (P<0.05). In conclusion, a lower MYH expression level in esophageal cell carcinoma tissue was inversely associated with more severe 8-oxoG oxidative damage, suggesting that changes in MYH activity correspond to increased DNA damage in tumor cells. The use of MYH expression as a postoperative index for esophageal squamous cell carcinoma may guide the formulation of individualized chemotherapy for patients after surgery.

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November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shen K, Ji Y, Chen G, Huang B, Zhang X, Wu S, Yu G and Wang X: Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma Retraction in /10.3892/etm.2016.3171. Exp Ther Med 2: 1117-1120, 2011
APA
Shen, K., Ji, Y., Chen, G., Huang, B., Zhang, X., Wu, S. ... Wang, X. (2011). Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma Retraction in /10.3892/etm.2016.3171. Experimental and Therapeutic Medicine, 2, 1117-1120. https://doi.org/10.3892/etm.2011.320
MLA
Shen, K., Ji, Y., Chen, G., Huang, B., Zhang, X., Wu, S., Yu, G., Wang, X."Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma Retraction in /10.3892/etm.2016.3171". Experimental and Therapeutic Medicine 2.6 (2011): 1117-1120.
Chicago
Shen, K., Ji, Y., Chen, G., Huang, B., Zhang, X., Wu, S., Yu, G., Wang, X."Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma Retraction in /10.3892/etm.2016.3171". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1117-1120. https://doi.org/10.3892/etm.2011.320