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Article

Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury

  • Authors:
    • Yong Guo
    • Kui-Po Yan
  • View Affiliations / Copyright

    Affiliations: Neurosurgical Intensive Care Unit, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Key Unit of the 11th Five-year Plan of SATCM in Cerebrosis, Xiangya Hospital, Central South University, Changsha 410008, P.R. China
  • Pages: 1133-1139
    |
    Published online on: August 18, 2011
       https://doi.org/10.3892/etm.2011.339
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Abstract

Acute kidney injury (AKI) is a common clinical problem which occurs in critically ill patients. Sepsis is now recognized as the most important contributing factor to AKI in this population. In clinical practice, certain studies have explored the urine neutrophil gelatinase-associated lipocalin (uNGAL) and the urine kidney injury molecule-1 (uKIM-1) as diagnostic and prognostic indices of AKI. Yet, it remains unclear whether uNGAL and uKIM-1 are associated with measures of disease severity and with adverse clinical outcomes in patients with established septic AKI of mixed cause and severity. Ninety-two septic patients with AKI were enrolled in a pilot study to test whether uKIM and uNGAL levels predict 180-day mortality. We initially performed univariate Cox proportional hazards analyses incorporating multiple demographic, clinical and laboratory variables. As a result, the APACHE Ⅱ score (p=0.014) and uNGAL (p=0.015) were identified as independent predictors of 180-day mortality. On the other hand, there was no statistical difference in event-free survival between patients with and without higher serum creatinine, creatinine clearance and uKIM-1 (data not shown). In conclusion, uNGAL may be a promising predictor for septic patients with AKI, resulting in a clear increase in 180-day mortality. Further clinical evaluation of uNGAL is underway.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Y and Yan K: Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury. Exp Ther Med 2: 1133-1139, 2011.
APA
Guo, Y., & Yan, K. (2011). Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury. Experimental and Therapeutic Medicine, 2, 1133-1139. https://doi.org/10.3892/etm.2011.339
MLA
Guo, Y., Yan, K."Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury". Experimental and Therapeutic Medicine 2.6 (2011): 1133-1139.
Chicago
Guo, Y., Yan, K."Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1133-1139. https://doi.org/10.3892/etm.2011.339
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y and Yan K: Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury. Exp Ther Med 2: 1133-1139, 2011.
APA
Guo, Y., & Yan, K. (2011). Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury. Experimental and Therapeutic Medicine, 2, 1133-1139. https://doi.org/10.3892/etm.2011.339
MLA
Guo, Y., Yan, K."Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury". Experimental and Therapeutic Medicine 2.6 (2011): 1133-1139.
Chicago
Guo, Y., Yan, K."Prognostic significance of urine neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1133-1139. https://doi.org/10.3892/etm.2011.339
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