Prediction of postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease

Iyoda,Akira; Jiang,Shi-Xu; Amano,Hideki; Ogawa,Fumihiro; Matui,Yoshio; Kurouzu,Naomi; Hara,Hidenori; Nezu,Kenji; Mikami,Tetsuo; Saegusa,Makoto; Satoh,Yukitoshi

doi:10.3892/etm.2011.342

November-December 2011 Volume 2 Issue 6

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November-December 2011 Volume 2 Issue 6

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Article

Prediction of postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease

Authors:
- Akira Iyoda
- Shi-Xu Jiang
- Hideki Amano
- Fumihiro Ogawa
- Yoshio Matui
- Naomi Kurouzu
- Hidenori Hara
- Kenji Nezu
- Tetsuo Mikami
- Makoto Saegusa
- Yukitoshi Satoh
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Kitasato University, School of Medicine, Sagamihara, Kanagawa 252-0374, Japan, Department of Pathology, Kitasato University, School of Medicine, Sagamihara, Kanagawa 252-0374, Japan
Pages: 1073-1076
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Published online on: August 24, 2011

https://doi.org/10.3892/etm.2011.342
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Abstract

Postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease has emerged as a serious problem. Therefore, the risk factors for postoperative exacerbation of interstitial pneumonia in patients with interstitial lung disease must be identified. We analyzed 22 patients diagnosed as having lung cancer with interstitial lung disease who underwent surgical treatment at the Kitasato University Hospital. Among the patients with lung cancer and interstitial lung disease, 5 patients (22.7%) had postoperative exacerbation of interstitial pneumonia. The prognosis of the patients with postoperative exacerbation was significantly poorer than that of patients without. Patients with postoperative exacerbation had a significantly higher age (≥75 years) and a significantly lower frequency of postoperative administration of steroid than patients without postoperative exacerbation. Almost all patients with postoperative exacerbation underwent lobectomy, had elevated KL-6 levels in the serum pre-operatively, and had significantly advanced stages of disease. Of the 5 patients with postoperative exacerbation, 2 had a history of inflammation prior to their exacerbation: 1 had a common cold and the other pyothorax. In patients with lung cancer and interstitial lung disease, advanced age, advanced stage disease, no postoperative administration of steroid and a pre-operative episode of inflammation are all risk factors for postoperative exacerbation of interstitial pneumonia.

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1	Kutlu CA, Williams EA, Evans TW, Pastorino U and Goldstraw P: Acute lung injury and acute respiratory distress syndrome after pulmonary resection. Ann Thorac Surg. 69:376–380. 2000. View Article : Google Scholar
2	Ruffini E, Parola A, Papalia E, Filosso PL, Mancuso M, Oliaro A, Actis-Dato G and Maggi G: Frequency and mortality of acute lung injury and acute respiratory distress syndrome after pulmonary resection for bronchogenic carcinoma. Eur J Cardiothorac Surg. 20:30–36. 2001. View Article : Google Scholar : PubMed/NCBI
3	Takeda S, Maeda H, Sawabata N, Kitada S, Mori M, Takashima S and Matsubara Y: Clinical impact of interstitial pneumonia following surgery for lung cancer. Thorac Cardiovasc Surg. 54:268–272. 2006. View Article : Google Scholar : PubMed/NCBI
4	Chiyo M, Sekine Y, Iwata T, Tatsumi K, Yasufuku K, Iyoda A, Otsuji M, Yoshida S, Shibuya K, Iizasa T, Saitoh Y and Fujisawa T: Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes. J Thorac Cardiovasc Surg. 126:1141–1146. 2003. View Article : Google Scholar : PubMed/NCBI
5	American Thoracic Society; European Respiratory Society: American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 165:277–304. 2002.
6	Nakajima J, Takamoto S, Murakawa T, Fukami T and Sano A: Is interstitial pneumonia in patients with collagen diseases a contraindication to lung cancer surgery? Surg Today. 37:14–18. 2007. View Article : Google Scholar : PubMed/NCBI
7	Muraoka M, Tagawa T, Akamine S, Oka T, Tsuchiya T, Araki M, Hayashi T and Nagayasu T: Acute interstitial pneumonia following surgery for primary lung cancer. Eur J Cardiothorac Surg. 30:657–662. 2006. View Article : Google Scholar : PubMed/NCBI
8	Koizumi K, Hirata T, Hirai K, Mikami I, Okada D, Yamagishi S, Kawashima T, Nakajima Y and Shimizu K: Surgical treatment of lung cancer combined with interstitial pneumonia: the effect of surgical approach on postoperative acute exacerbation. Ann Thorac Cardiovasc Surg. 10:340–346. 2004.PubMed/NCBI
9	Chida M, Ono S, Hoshikawa Y and Kondo T: Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery. Eur J Cardiothorac Surg. 34:878–881. 2008. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prediction of postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease

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Abstract

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