Diagnostic value of interleukin 22 and carcinoembryonic antigen in tuberculous and malignant pleural effusions

Jin,Di; Chen,Ying; Wang,Zhengyun; Wang,Siwei; Bunjhoo,Hansvin; Zhu,Jing; Cao,Yong; Xiong,Weining; Xiong,Shengdao; Xu,Yongjian; Fang,Huijuan

doi:10.3892/etm.2011.344

Diagnostic value of interleukin 22 and carcinoembryonic antigen in tuberculous and malignant pleural effusions

Authors:
- Di Jin
- Ying Chen
- Zhengyun Wang
- Siwei Wang
- Hansvin Bunjhoo
- Jing Zhu
- Yong Cao
- Weining Xiong
- Shengdao Xiong
- Yongjian Xu
- Huijuan Fang
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Affiliations: Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China, Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China
Published online on: August 25, 2011 https://doi.org/10.3892/etm.2011.344
Pages: 1205-1209

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Abstract

The aim of this study was to investigate the diagnostic value of interleukin 22 (IL-22) and carcinoembryonic antigen (CEA) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion samples from 56 patients were classified on the basis of diagnosis as TPE (n=28) and MPE (n=28). The concentration of IL-22 was determined by ELISA. Lactate dehydrogenase (LDH), adenosine dehydrogenase (ADA) and CEA levels were also determined in all patients. A significant difference was observed in the levels of ADA and CEA (P<0.01), but not in the levels of LDH (P>0.05) between TPE and MPE. The concentration of IL-22 in TPE was significantly higher compared to MPE (P<0.01). With a threshold value of 49 pg/ml, IL-22 had a sensitivity of 82.14% (23/28) and a specificity of 96.43% (27/28) for differential diagnosis. The combined detection of IL-22 and CEA had a sensitivity of 100% (28/28) and a specificity of 96.43% (27/28) to distinguish TPE from MPE. TPEs showed significantly higher levels of IL-22 compared to MPEs. The combined detection of IL-22 and CEA may be more valuable in the differential diagnosis between TPE and MPE.

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