Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study
- Authors:
- Khor Yen Haw
- Srikumar Chakravarthi
- Nagaraja Haleagrahara
- Mallikarjuna Rao
-
View Affiliations
Affiliations: Department of Post Graduate Studies, Research Laboratory, International Medical University, Kuala Lumpur, Malaysia, Department of Pathology, Faculty of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia, Department of Human Biology, Faculty of Medicine, International Medical University, Kuala Lumpur, Malaysia, Department of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
- Published online on: September 21, 2011 https://doi.org/10.3892/etm.2011.355
-
Pages:
99-104
Metrics:
Total
Views: 0 (Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
Lead causes damage to the whole body by inducing oxidative stress. This includes the testis, in which spermatogenesis is affected. Etlingera elatior, a consumable plant that is being extensively studied for its high anti-oxidant properties, was tested against the effect of lead acetate in experimental rats. Rats were divided into groups consisting of a control, lead acetate only, Etlingera elatior treatment only, concurrent treatment of lead acetate and Etlingera elatior, post-treatment of lead acetate followed by Etlingera elatior and preventive group of Etlingera elatior followed by lead acetate. The substances were administered for 14 days and the effects were measured by protein carbonyl content (PCC), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity in the testis, as well as the testosterone level in the serum. Histological changes in the testis were also observed. Results showed that Etlingera elatior induced a significant reduction in the testis PCC activity, while at the same time it significantly increased the activities of SOD and GPx in the testis, and the testosterone level in the serum. Etlingera elatior also improved the histology of the testis when compared to the lead acetate-treated group. On the whole, Etlingera elatior is effective against oxidative damage caused by lead acetate in the testis.
View References
|
1.
|
H FuP BoffettaCancer and occupational
exposure to inorganic lead compounds: a meta-analysis of published
dataOccup Environ Med527381199510.1136/oem.52.2.737757170
|
|
2.
|
T DamstraToxicological properties of
leadEnviron Health Perspect19297307197710.1289/ehp.7719297
|
|
3.
|
JI RaderJT PeelerKR MahaffeyComparative
toxicity and tissue distribution of lead acetate in weanling and
adult ratsEnviron Health
Perspect42187195198110.1289/ehp.81421877333253
|
|
4.
|
WW ManserR LalaniS HaiderMA KhanTrace
element studies on Karachi populations. Part V: Blood lead levels
in normal healthy adults and grammar school childrenJ Pak Med
Assoc4015015419901703243
|
|
5.
|
F GorbelM BoujelbeneF Makni-AyadiF
GuermaziF CrouteJP SoleilhavoupA el FekiCytotoxic effects of lead
on the endocrine and exocrine sexual function of pubescent male and
female rats. Demonstration of apoptotic activityC R
Biol325927940200212481686
|
|
6.
|
PJ LandriganCurrent issues in the
epidemiology and toxicology of occupational exposure to leadEnviron
Health Perspect896166199010.1289/ehp.9089612088757
|
|
7.
|
M RodamilansMJ OsabaJ To-FiguerasF Rivera
FillatJM MarquesP PerezJ CorbellaLead toxicity on endocrine
testicular function in an occupationally exposed populationHum
Toxicol7125128198810.1177/0960327188007002033132417
|
|
8.
|
DK SaxenaRS SrivastavaB LalSV ChandraThe
effect of lead exposure on the testis of growing ratsExp
Pathol31249252198710.1016/S0232-1513(87)80010-53622725
|
|
9.
|
EWC ChanYY LimM OmarAntioxidant and
antibacterial activity of leaves of Etlingera species
(Zingiberaceae) in Peninsular MalaysiaFood
Chem10415861593200710.1016/j.foodchem.2007.03.023
|
|
10.
|
H MohamadNH LajisF AbasAM AliMA SukariH
KikuzakiN NakataniAntioxidant constituents of Etlingera
elatiorJ Nat Prod68285288200510.1021/np040098l
|
|
11.
|
A WuTietz Clinical Guide to Laboratory
Tests4th editionSaunders ElsevierSt. Louis, MO6586592006
|
|
12.
|
M MarchlewiczB WiszniewskaB GonetI
Baranowska-BasiockaK SafranowA KolasaW GlabowskiR KurzawaK
JakubowskaME RacIncreased lipid peroxidation and ascorbic acid
utilization in testis and epididymis of rats chronically exposed to
leadBiometals201319200710.1007/s10534-006-9009-z16699871
|
|
13.
|
Q RanH LiangY IkenoW QiTA ProllaLJ Roberts
IIN WolfH van RemmenA RichardsonReduction in glutathione peroxidase
4 increases life span through increased sensitivity to apoptosisJ
Gerontol A Biol Sci Med
Sci62932942200710.1093/gerona/62.9.93217895430
|
|
14.
|
S MarklundDistribution of Cu Zn superoxide
dismutase and Mn superoxide dismutase in human tissues and
extracellular fluidsActa Physiol Scand492S19S2319806939305
|
|
15.
|
F UrsiniM MaiorinoC GregolinThe
selenoenzyme phospholipid hydroperoxide glutathione
peroxidaseBiochim Biophys
Acta8396270198510.1016/0304-4165(85)90182-5
|
|
16.
|
JW ForstromJJ ZakowskiAL
TappelIdentification of the catalytic site of rat liver glutathione
peroxidase as
selenocysteineBiochemistry1726392644197810.1021/bi00606a028678534
|
|
17.
|
ER StadtmanCN OliverMetal-catalyzed
oxidation of proteins: physiological consequencesJ Biol
Chem2662005200819911989966
|
|
18.
|
V SharmaL KansalA SharmaProphylactic
efficacy of Coriandrumsativum (Coriander) on testis of
lead-exposed miceBiol Trace Elem Res1363373542010
|
|
19.
|
M MarchlewiczT MichalskaB
WiszniewskaDetection of lead-induced oxidative stress in the rat
epididymis by
chemiluminescenceChemosphere5715531562200410.1016/j.chemosphere.2004.08.10215519400
|
|
20.
|
N HaleagraharaT JackieS ChakravarthiM RaoT
PasupathiProtective effects of Etlingera elatior extract on
lead acetate-induced changes in oxidative biomarkers in bone marrow
of ratsFood Chem Toxicol48268826942010
|
|
21.
|
N HaleagraharaT JackieS ChakravarthiM RaoA
KulurProtective effect of Etlingera elatior (torch ginger)
extract on lead acetate – induced hepatotoxicity in ratsJ Toxicol
Sci356636712011
|
|
22.
|
I AhmadM SabirKF YasinStudy of the effects
of lead poisoning on the testes in albino ratsPak J Med
Res4222562622003
|
|
23.
|
NW GhelbergE BordasLead-induced
experimental lesions of the testis and their treatmentJ Appl
Toxicol1284286198110.1002/jat.25500105097185889
|
|
24.
|
EWC ChanYY LimLF WongFS LiantoSK WongKK
LimCE JoeTY LimAntioxidant and tyrosinase inhibition properties of
leaves and rhizomes of ginger speciesFood
Chem109477483200810.1016/j.foodchem.2008.02.016
|
