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Review

Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)

  • Authors:
    • Yasuhito Tanase
    • Yoshihiko Yamada
    • Hiroshi Shigetomi
    • Hirotaka Kajihara
    • Akira Oonogi
    • Yoriko Yoshizawa
    • Naoto Furukawa
    • Shoji Haruta
    • Shozo Yoshida
    • Toshiyuki Sado
    • Hidekazu Oi
    • Hiroshi Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
  • Pages: 18-24
    |
    Published online on: October 24, 2011
       https://doi.org/10.3892/etm.2011.376
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Abstract

Two histologic types, clear cell carcinoma (CCC) and endometrioid adenocarcinoma (EAC), are the common histology in ovarian cancer patients who have associated endometriosis. However, both tumor types have distinct clinicopathological characteristics and molecular phenotypes. EAC is predominantly positive for estrogen receptor (ER), but CCC specifically exhibits lower ER expression. This study reviews the current understanding of the role of the ER information in the pathogenesis of CCC, as well as the English language literature for biochemical studies on ER expression and estrogenic action in CCC. The iron-mediated oxidative stress occurs due to repeated hemorrhage in endometriosis, then this compound oxidatively modifies genomic DNA and, subsequently, ER depletion may be observed. There are a number of factors that interfere with ER expression and estrogen activity, which include DNA methylation of the promoter region, histone deacetylation, heme and iron binding, chromatin remodeling and ubiquitin ligase activity. Loss of estrogen function may be a turning point in CCC progression and aggressiveness.
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Copy and paste a formatted citation
Spandidos Publications style
Tanase Y, Yamada Y, Shigetomi H, Kajihara H, Oonogi A, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Sado T, et al: Modulation of estrogenic action in clear cell carcinoma of the ovary (Review). Exp Ther Med 3: 18-24, 2012.
APA
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y. ... Kobayashi, H. (2012). Modulation of estrogenic action in clear cell carcinoma of the ovary (Review). Experimental and Therapeutic Medicine, 3, 18-24. https://doi.org/10.3892/etm.2011.376
MLA
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y., Furukawa, N., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)". Experimental and Therapeutic Medicine 3.1 (2012): 18-24.
Chicago
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y., Furukawa, N., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)". Experimental and Therapeutic Medicine 3, no. 1 (2012): 18-24. https://doi.org/10.3892/etm.2011.376
Copy and paste a formatted citation
x
Spandidos Publications style
Tanase Y, Yamada Y, Shigetomi H, Kajihara H, Oonogi A, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Sado T, et al: Modulation of estrogenic action in clear cell carcinoma of the ovary (Review). Exp Ther Med 3: 18-24, 2012.
APA
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y. ... Kobayashi, H. (2012). Modulation of estrogenic action in clear cell carcinoma of the ovary (Review). Experimental and Therapeutic Medicine, 3, 18-24. https://doi.org/10.3892/etm.2011.376
MLA
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y., Furukawa, N., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)". Experimental and Therapeutic Medicine 3.1 (2012): 18-24.
Chicago
Tanase, Y., Yamada, Y., Shigetomi, H., Kajihara, H., Oonogi, A., Yoshizawa, Y., Furukawa, N., Haruta, S., Yoshida, S., Sado, T., Oi, H., Kobayashi, H."Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)". Experimental and Therapeutic Medicine 3, no. 1 (2012): 18-24. https://doi.org/10.3892/etm.2011.376
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