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Article

Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations

  • Authors:
    • Wen-Shuo Wu
    • Yuh-Min Chen
    • Chun-Ming Tsai
    • Jen-Fu Shih
    • Chao-Hua Chiu
    • Kun‑Ta  Chou
    • Shinn-Liang Lai
    • Chieh-Hung Wu
    • Yung-Hung Luo
    • Chu‑Yun  Huang
    • Yu-Chin Lee
    • Reury-Perng Perng
    • Jacqueline Whang-Peng
  • View Affiliations / Copyright

    Affiliations: Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C., CECR, School of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.
  • Pages: 207-213
    |
    Published online on: November 16, 2011
       https://doi.org/10.3892/etm.2011.383
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Abstract

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are an effective treatment for advanced non-small cell lung cancer. The objective of the present study was to compare the efficacy of gefitinib and erlotinib in patients with pulmonary adenocarcinoma, whose tumor EGFR mutation status was known. Pulmonary adenocarcinoma patients who began receiving gefitinib or erlotinib treatment from January 2005 to December 2010, and whose tumor EGFR mutation status had been determined, were included. Clinical data, type of treatment response and survival time data were collected. Of the 224 patients enrolled, 124 received gefitinib treatment and 100 received erlotinib treatment. Of these patients, 146 individuals had tumors with EGFR‑activating mutations (exon 19 deletions and/point mutation of L858R in exon 21) and 78 did not. There was no difference in treatment response whether or not the patients had tumors with EGFR-activating mutations at the time they received gefitinib or erlotinib treatment. The median progression‑free survival (PFS) of the gefitinib and erlotinib groups was 7.6 and 7.9 months, respectively (p=0.4731). PFS was significantly longer for patients without EGFR-activating mutations who received erlotinib treatment (n=48; median, 4.5 months) than for those who received gefitinib treatment (n=30; median, 2.3 months), with a hazard ratio of 0.58 (95% CI, 0.35-0.96; p=0.0339). Patients whose tumors had EGFR-activating mutations displayed no difference in PFS with either gefitinib (n=94; median, 10.5 months) or erlotinib treatment (n=52; median, 10.4 months). In conclusion, PFS showed no difference with either agent in patients whose tumors had EGFR-activating mutations, but was significantly longer in patients whose tumors did not have EGFR-activating mutations when receiving erlotinib treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Chen Y, Tsai C, Shih J, Chiu C, Chou KT, Lai S, Wu C, Luo Y, Huang CY, Huang CY, et al: Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations. Exp Ther Med 3: 207-213, 2012.
APA
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K. ... Whang-Peng, J. (2012). Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations. Experimental and Therapeutic Medicine, 3, 207-213. https://doi.org/10.3892/etm.2011.383
MLA
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K., Lai, S., Wu, C., Luo, Y., Huang, C., Lee, Y., Perng, R., Whang-Peng, J."Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations". Experimental and Therapeutic Medicine 3.2 (2012): 207-213.
Chicago
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K., Lai, S., Wu, C., Luo, Y., Huang, C., Lee, Y., Perng, R., Whang-Peng, J."Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations". Experimental and Therapeutic Medicine 3, no. 2 (2012): 207-213. https://doi.org/10.3892/etm.2011.383
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Chen Y, Tsai C, Shih J, Chiu C, Chou KT, Lai S, Wu C, Luo Y, Huang CY, Huang CY, et al: Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations. Exp Ther Med 3: 207-213, 2012.
APA
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K. ... Whang-Peng, J. (2012). Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations. Experimental and Therapeutic Medicine, 3, 207-213. https://doi.org/10.3892/etm.2011.383
MLA
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K., Lai, S., Wu, C., Luo, Y., Huang, C., Lee, Y., Perng, R., Whang-Peng, J."Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations". Experimental and Therapeutic Medicine 3.2 (2012): 207-213.
Chicago
Wu, W., Chen, Y., Tsai, C., Shih, J., Chiu, C., Chou, K., Lai, S., Wu, C., Luo, Y., Huang, C., Lee, Y., Perng, R., Whang-Peng, J."Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations". Experimental and Therapeutic Medicine 3, no. 2 (2012): 207-213. https://doi.org/10.3892/etm.2011.383
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