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Article

Association between cytochrome P450 promoter polymorphisms and ischemic stroke

  • Authors:
    • Su Kang Kim
    • Sung-Vin Yim
    • Byung-Cheol Lee
  • View Affiliations / Copyright

    Affiliations: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea
  • Pages: 261-268
    |
    Published online on: November 22, 2011
       https://doi.org/10.3892/etm.2011.388
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Abstract

The human cytochrome P450 (CYP) superfamily includes at least 57 genes that encode enzymes with diverse metabolic and biosynthetic functions. This study was conducted in order to investigate the associations between polymorphisms in CYP superfamily genes (CYP11B2, CYP17A1, CYP2B6, CYP2C9, CYP2E1 and CYP7A1) and ischemic stroke (IS). Six single nucleotide polymorphisms (SNPs) of CYP superfamily genes were selected and genotyped by direct sequencing in 121 patients with IS and 321 control subjects. The genetic data were analyzed using SNPStats and SPSS 18.0. Multiple logistic regression models (codominant 1, codominant 2, dominant, recessive and log-additive) were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs) and p-values. The rs179998 SNP of CYP11B2 was significantly associated with IS (p=0.0336 in a log-additive model). The rs3813867 SNP of CYP2E1 was significantly associated with smoking in IS (p=0.0336 in a log-additive model). The rs1799998 SNP of CYP11B2 and rs3808607 of CYP7A1 were related to diabetes mellitus in IS (p<0.05). CYP11B2, CYP2E1 and CYP7A1 SNPs were associated with IS in the population studied. Further study is required to confirm these associations and to determine their biological significance.
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1. 

D Lloyd-JonesRJ AdamsTM BrownExecutive summary: heart disease and stroke statistics - 2010 update: a report from the American Heart AssociationCirculation121948954201010.1161/CIRCULATIONAHA.109.19266620177011

2. 

JA ZivinFactors determining the therapeutic window for strokeNeurology50599603199810.1212/WNL.50.3.5999521242

3. 

AG SorensenWA CopenL OstergaardHyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit timeRadiology210519527199910207439

4. 

F GonnerL RemondaH MattleLocal intra-arterial thrombolysis in acute ischemic strokeStroke2918941900199810.1161/01.STR.29.9.18949731615

5. 

SG RichardsonKB MatthewsJ StuartAM GeddesRM WilcoxSerial changes in coagulation and viscosity during sickle-cell crisisBr J Haematol4195103197910.1111/j.1365-2141.1979.tb03685.x420740

6. 

SH SukRL SaccoB Boden-AlbalaAbdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke StudyStroke3415861592200310.1161/01.STR.0000075294.98582.2F12775882

7. 

Y WinterS RohrmannJ LinseisenContribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacksStroke3931453151200810.1161/STROKEAHA.108.52300118703800

8. 

AR FolsomML RasmussenLE ChamblessProspective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study InvestigatorsDiabetes Care2210771083199910.2337/diacare.22.7.107710388971

9. 

J CastilloR LeiraMM GarciaBlood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcomeStroke35520526200410.1161/01.STR.0000109769.22917.B014726553

10. 

AW Weverling-RijnsburgerIJ JonkersE van ExelJ GusseklooRG WestendorpHigh-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old ageArch Intern Med16315491554200310.1001/archinte.163.13.154912860577

11. 

RX YouAG ThriftJJ McNeilSM DavisGA DonnanIschemic stroke risk and passive exposure to spouses’ cigarette smoking. Melbourne Stroke Risk Factor Study (MERFS) GroupAm J Public Health895725751999

12. 

DW NebertDW RussellClinical importance of the cytochromes P450Lancet36011551162200210.1016/S0140-6736(02)11203-712387968

13. 

XQ PanYH ZhangYY LiuWJ TongInteraction between the C(−344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian populationEur J Epidemiol258138212010

14. 

X PanY LiuY ZhangInteraction of the C-344T polymorphism of CYP11b2 gene with body mass index and waist circumference affecting diastolic blood pressure in Chinese Mongolian populationBlood Press19373379201010.3109/08037051.2010.49585920560800

15. 

C LiuH LiQ QiCommon variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese HansJ Hypertens297075201010.1097/HJH.0b013e32833f60ab20852445

16. 

H SchunkertIR KonigS KathiresanLarge-scale association analysis identifies 13 new susceptibility loci for coronary artery diseaseNat Genet43333338201010.1038/ng.78421378990

17. 

ZH YuanQ LiuY ZhangCYP2B6 gene single nucleotide polymorphisms and leukemia susceptibilityAnn Hematol90293299201010.1007/s00277-010-1085-z20878158

18. 

HZ RingAM ValdesDM NishitaGene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolismPharmacogenet Genomics1710071015200710.1097/01.fpc.0000220560.59972.3318004205

19. 

M SamardzijaE TopicM StefanovicAssociation of CYP2C9 gene polymorphism with bleeding as a complication of warfarin therapyColl Antropol32557564200818756910

20. 

T YinK MaekawaK KamideGenetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartanHypertens Res3115491557200810.1291/hypres.31.154918971529

21. 

SY EomYW ZhangSH KimInfluence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in KoreansCancer Causes Control20137145200910.1007/s10552-008-9225-718798003

22. 

A PoduriM KhullarA BahlYP SharmaKK TalwarA combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian IndiansDNA Cell Biol28451460200910.1089/dna.2009.088719558216

23. 

YS WeiY LanLQ MengLG NongThe association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic strokeJ Thromb Thrombolysis32110115201110.1007/s11239-011-0587-421465128

24. 

MY CheongOS BangMH ChaAssociation of the adiponectin gene variations with risk of ischemic stroke in a Korean populationYonsei Med J522025201010.3349/ymj.2011.52.1.2021155030

25. 

XL ChenJQ ChengRL ZhangStudy on the relationship between polymorphism of adiponectin gene and risk of ischemic stroke among Han population in the Northern parts of ChinaZhonghua Liu Xing Bing Xue Za Zhi31129132201021215068

26. 

A de Paula SabinoDD RibeiroCP DominguetiPlasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic strokeMol Biol Rep3853555360201121373825

27. 

J KalitaBI SomarajanB KumarB MittalUK MisraA study of ACE and ADD1 polymorphism in ischemic and hemorrhagic strokeClin Chim Acta412642646201010.1016/j.cca.2010.12.02221194526

28. 

B JinHC NiW ShenCytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrelMol Biol Rep3816971702201010.1007/s11033-010-0282-020845077

29. 

C FavaM MontagnanaP AlmgrenThe V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressureHypertension52373380200810.1161/HYPERTENSIONAHA.108.11419918574070

30. 

MJ O’DonnellD XavierL LiuRisk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control studyLancet376112123201020561675

31. 

Y TuG CuiY XuGenetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysisPharmacogenet Genomics21115120201010.1097/FPC.0b013e3283432a3221228735

32. 

NN KumarAV BenjafieldRC LinHaplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertensionJ Hypertens2113311337200310.1097/00004872-200307000-0002212817181

33. 

M MatsubaraT SatoT NishimuraCYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama studyHypertens Res2716200410.1291/hypres.27.115055249

34. 

LA HowardS MiksysE HoffmannD MashRF TyndaleBrain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholicsBr J Pharmacol13813761386200310.1038/sj.bjp.070514612711639

35. 

NM BelliliL FoucanF FumeronAssociations of the −344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French populationAm J Hypertens236606672010

36. 

P RussoF LauriaM Loguercio−344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in menAm J Hypertens202182222007

37. 

K RanadeKD WuN RischGenetic variation in aldosterone synthase predicts plasma glucose levelsProc Natl Acad Sci USA981321913224200110.1073/pnas.22146709811687612

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Yim S and Lee B: Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Exp Ther Med 3: 261-268, 2012.
APA
Kim, S., Yim, S., & Lee, B. (2012). Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Experimental and Therapeutic Medicine, 3, 261-268. https://doi.org/10.3892/etm.2011.388
MLA
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3.2 (2012): 261-268.
Chicago
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3, no. 2 (2012): 261-268. https://doi.org/10.3892/etm.2011.388
Copy and paste a formatted citation
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Spandidos Publications style
Kim S, Yim S and Lee B: Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Exp Ther Med 3: 261-268, 2012.
APA
Kim, S., Yim, S., & Lee, B. (2012). Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Experimental and Therapeutic Medicine, 3, 261-268. https://doi.org/10.3892/etm.2011.388
MLA
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3.2 (2012): 261-268.
Chicago
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3, no. 2 (2012): 261-268. https://doi.org/10.3892/etm.2011.388
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