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Article

Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma

  • Authors:
    • Yongping Yang
    • Yinying Lu
    • Chunping Wang
    • Wenlin Bai
    • Jianhui Qu
    • Yan  Chen
    • Xiujuan Chang
    • Linjing An
    • Lin Zhou
    • Zhen Zeng
    • Min Lou
    • Jiyun Lv
  • View Affiliations / Copyright

    Affiliations: Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302nd Hospital, Beijing 100039, P.R. China
  • Pages: 171-180
    |
    Published online on: December 1, 2011
       https://doi.org/10.3892/etm.2011.398
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Abstract

Sorafenib may prolong survival in patients with advanced hepatocellular carcinoma (HCC), but with limited efficacy. The present study aimed to assess the safety and efficacy of sorafenib combined with cryotherapy (cryoRx) for the treatment of advanced HCC. A total of 104 patients met the following criteria: advanced HCC without distant metastasis, presence of portal vein thrombosis, Child-Pugh class A or B and life expectancy of at least 12 weeks. All patients were randomly assigned to sorafenib and cryoRx (n=52) or sorafenib-alone (n=52) treatment groups. The primary end-point of the study was overall survival (OS). The secondary end-points included time to progression (TTP) and tolerability. Microvessel density (MVD) was assessed following immunostaining for CD34. In a median of 10.5 (4-26) months follow-up, the median OS was 12.5 months (95% CI 10.6-16.4) in the combination therapy vs. 8.6 months (7.3-10.4) in the sorafenib-alone (P=0.01) group. The median TTP was 9.5 months (8.4‑13.5) in the combination therapy vs. 5.3 months (3.8-6.9) in the sorafenib alone (P=0.02) group. CryoRx was an independent factor associated with improved clinical outcomes of sorafenib for the treatment of advanced HCC. Patients with low intratumoral MVD receiving the combination therapy exhibited a significantly longer median TTP and OS compared to those receiving sorafenib. High intratumoral MVD was an independent predictor of poor responses to sorafenib for advanced HCC. Compared with previous reports of sorafenib-related adverse drug reactions (ADRs), cryoRx did not further increase the frequency and degree of sorafenib-related ADRs. In conclusion, compared to sorafenib alone, the addition of cryoRx to sorafenib significantly improves the clinical outcomes of sorafenib for the treatment of advanced HCC with acceptable tolerance and similar safety profiles as previously reported. High intratumoral MVD is predictive of poor responses to sorafenib in advanced HCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Lu Y, Wang C, Bai W, Qu J, Chen Y, Chang X, An L, Zhou L, Zeng Z, Zeng Z, et al: Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma. Exp Ther Med 3: 171-180, 2012.
APA
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y. ... Lv, J. (2012). Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3, 171-180. https://doi.org/10.3892/etm.2011.398
MLA
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y., Chang, X., An, L., Zhou, L., Zeng, Z., Lou, M., Lv, J."Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma". Experimental and Therapeutic Medicine 3.2 (2012): 171-180.
Chicago
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y., Chang, X., An, L., Zhou, L., Zeng, Z., Lou, M., Lv, J."Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma". Experimental and Therapeutic Medicine 3, no. 2 (2012): 171-180. https://doi.org/10.3892/etm.2011.398
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Lu Y, Wang C, Bai W, Qu J, Chen Y, Chang X, An L, Zhou L, Zeng Z, Zeng Z, et al: Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma. Exp Ther Med 3: 171-180, 2012.
APA
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y. ... Lv, J. (2012). Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3, 171-180. https://doi.org/10.3892/etm.2011.398
MLA
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y., Chang, X., An, L., Zhou, L., Zeng, Z., Lou, M., Lv, J."Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma". Experimental and Therapeutic Medicine 3.2 (2012): 171-180.
Chicago
Yang, Y., Lu, Y., Wang, C., Bai, W., Qu, J., Chen, Y., Chang, X., An, L., Zhou, L., Zeng, Z., Lou, M., Lv, J."Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma". Experimental and Therapeutic Medicine 3, no. 2 (2012): 171-180. https://doi.org/10.3892/etm.2011.398
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