Open Access

Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats

  • Authors:
    • Ryo Abe
    • Jun-Ichi Okano
    • Ryu Imamoto
    • Yuki Fujise
    • Yoshikazu Murawaki
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  • Published online on: December 15, 2011     https://doi.org/10.3892/etm.2011.419
  • Pages: 371-378
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Abstract

In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.
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March 2012
Volume 3 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Abe R, Okano J, Imamoto R, Fujise Y and Murawaki Y: Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats. Exp Ther Med 3: 371-378, 2012
APA
Abe, R., Okano, J., Imamoto, R., Fujise, Y., & Murawaki, Y. (2012). Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats. Experimental and Therapeutic Medicine, 3, 371-378. https://doi.org/10.3892/etm.2011.419
MLA
Abe, R., Okano, J., Imamoto, R., Fujise, Y., Murawaki, Y."Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats". Experimental and Therapeutic Medicine 3.3 (2012): 371-378.
Chicago
Abe, R., Okano, J., Imamoto, R., Fujise, Y., Murawaki, Y."Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats". Experimental and Therapeutic Medicine 3, no. 3 (2012): 371-378. https://doi.org/10.3892/etm.2011.419