Sequential analysis of diethylnitrosamine‑induced hepatocarcinogenesis in rats
- Authors:
- Ryo Abe
- Jun-Ichi Okano
- Ryu Imamoto
- Yuki Fujise
- Yoshikazu Murawaki
View Affiliations
Affiliations: Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Tottori 683-8504, Japan
- Published online on: December 15, 2011 https://doi.org/10.3892/etm.2011.419
-
Pages:
371-378
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Abstract
In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.
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View References
1.
|
FX BoschJ RibesJ BorrasEpidemiology of
primary liver cancerSemin Liver
Dis19271285199910.1055/s-2007-100711710518307
|
2.
|
HB El-SeragKL RudolphHepatocellular
carcinoma: epidemiology and molecular
carcinogenesisGastroenterology13225572576200710.1053/j.gastro.2007.04.06117570226
|
3.
|
PA FaraziRA DePinhoHepatocellular
carcinoma pathogenesis: from genes to environmentNat Rev
Cancer6674687200610.1038/nrc193416929323
|
4.
|
YC ShenC HsuAL ChengMolecular targeted
therapy for advanced hepatocellular carcinoma: current status and
future perspectivesJ
Gastroenterol45794807201010.1007/s00535-010-0270-020567987
|
5.
|
K MoriyaH FujieY ShintaniThe core protein
of hepatitis C virus induces hepatocellular carcinoma in transgenic
miceNat Med410651067199810.1038/20539734402
|
6.
|
Y HorieA SuzukiE
KataokaHepatocyte-specific Pten deficiency results in
steatohepatitis and hepatocellular carcinomasJ Clin
Invest11317741783200410.1172/JCI2051315199412
|
7.
|
A TakaiT ToyoshimaM UemuraA novel mouse
model of hepatocarcinogenesis triggered by AID causing deleterious
p53 mutationsOncogene28469478200910.1038/onc.2008.41518997814
|
8.
|
M El-ShahatS El-AbdM AlkafafyG
El-KhatibPotential chemoprevention of diethylnitrosamine-induced
hepatocarcinogenesis in rats: Myrrh (Commiphora molmol) vs.
turmeric (Curcuma longa)Acta HistochemAug252011(E-pub ahead
of print)
|
9.
|
SS Al-RejaieAM AleisaAA
Al-YahyaProgression of diethylnitrosamine-induced hepatic
carcinogenesis in carnitine-depleted ratsWorld J
Gastroenterol1513731380200910.3748/wjg.15.137319294768
|
10.
|
L VernaJ WhysnerGM
WilliamsN-nitrosodiethylamine mechanistic data and risk assessment:
bioactivation, DNA-adduct formation, mutagenicity, and tumor
initiationPharmacol
Ther715781199610.1016/0163-7258(96)00062-98910949
|
11.
|
S JayakumarA MadankumarS
AsokkumarPotential preventive effect of carvacrol against
diethylnitrosamine-induced hepatocellular carcinoma in ratsMol Cell
BiochemAug312011(E-pub ahead of print)
|
12.
|
DB SoltE CayamaH TsudaK EnomotoG LeeE
FarberPromotion of liver cancer development by brief exposure to
dietary 2-acetylaminofluorene plus partial hepatectomy or carbon
tetrachlorideCancer Res4318819119836291753
|
13.
|
S-E ChuangA-L ChengJ-K LinM-L
KuoInhibition by curcumin of diethylnitrosamine-induced hepatic
hyperplasia, inflammation, cellular gene products and
cell-cycle-related proteins in ratsFood Chem
Toxicol38991995200010.1016/S0278-6915(00)00101-011038236
|
14.
|
G ShiotaK HaradaM IshidaInhibition of
hepatocellular carcinoma by glycyrrhizin in
diethylnitrosamine-treated
miceCarcinogenesis205963199910.1093/carcin/20.1.599934850
|
15.
|
RA SquireMH LevittReport of a workshop on
classification of specific hepatocellular lesions in ratsCancer
Res35321432231975171067
|
16.
|
M SakaiM MuramatsuRegulation of
glutathione transferase P: a tumor marker of
hepatocarcinogenesisBiochem Biophys Res
Commun357575578200710.1016/j.bbrc.2007.03.17417434454
|
17.
|
FQ AlenziEM El-NasharSS
Al-GhamdiInvestigation of Bcl-2 and PCNA in hepatocellular
carcinoma: relation to chronic HCVJ Egypt Natl Canc
Inst228794201021503011
|
18.
|
J OkanoY FujiseR AbeR ImamotoY
MurawakiChemo-prevention against hepatocellular carcinomaClin J
Gastroenterol4185197201110.1007/s12328-011-0227-8
|