Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March 2012 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2012 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Interaction of Staphylococcus aureus with osteoblasts (Review)

  • Authors:
    • Sifeng Shi
    • Xianlong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Jiao Tong University, Shanghai, P.R. China
  • Pages: 367-370
    |
    Published online on: December 20, 2011
       https://doi.org/10.3892/etm.2011.423
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Orthopedic infection is refractory to cure. Staphylococcus aureus (S. aureus) is the main causative pathogen responsible for orthopedic infection. S. aureus is capable of not only colonizing bone matrix, but also invading osteoblasts, which may play a significant role in the persistence and recurrence of osteomyelitis. Internalization requires the involvement of cytoskeletal elements, including actin microfilaments, microtubules and clathrin-coated pits. Microfilaments are most significant in the invasion process. S. aureus is capable of remaining alive in osteoblasts for a long period of time. Decreased sensitivity to antibiotics capable of penetrating host cells increases the difficulties of eradicating S. aureus. Osteoblasts, invaded by S. aureus, play a significant role in the initiation and maintenance of inflammatory immune responses. These osteoblasts recruit leukocytes and phagocytes to the site of inflammation via the expression of cytokines. Apoptosis is observed in osteoblasts invaded by S. aureus. Recruitment of osteoclasts and other immunocytes plays a crucial role in the resorption and destruction of bone.
View Figures
View References

1. 

S ChiharaJ SegretiOsteomyelitisDis Mon56631201010.1016/j.disamonth.2009.07.001

2. 

N RaoBH ZiranBA LipskyTreating osteomyelitis: antibiotics and surgeryPlast Reconstr Surg127Suppl 1S177S187201110.1097/PRS.0b013e3182001f0f

3. 

G StocksHF JanssenInfection in patients after implantation of an orthopedic deviceASAIO J46S41S46200010.1097/00002480-200011000-0003611110293

4. 

LX WebbW WagnerD CarrollH TylerF ColdrenE MartinOsteomyelitis and intraosteoblastic Staphylococcus aureusJ Surg Orthop Adv1673782007

5. 

RA BradyGA O’MayJG LeidML PriorJW CostertonME ShirtliffResolution of Staphylococcus aureus biofilm infection using vaccination and antibiotic treatmentInfect Immun7917971803201121220484

6. 

C GarzoniWL KelleyStaphylococcus aureus: new evidence for intracellular persistenceTrends Microbiol175965200910.1016/j.tim.2008.11.005

7. 

S AhmedS MeghjiRJ WilliamsB HendersonJH BrockSP NairStaphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteriaInfect Immun6928722877200110.1128/IAI.69.5.2872-2877.2001

8. 

EH AlexanderJL BentoFM HughesI MarriottMC HudsonKL BostStaphylococcus aureus and Salmonella enterica serovar dublin induce tumor necrosis factor-related apoptosis-inducing ligand expression by normal mouse and human osteoblastsInfect Immun6915811586200110.1128/IAI.69.3.1581-1586.2001

9. 

CV GayVR GilmanT SugiyamaPerspectives on osteoblast and osteoclast functionPoult Sci7910051008200010.1093/ps/79.7.100510901202

10. 

RA AlmeidaKR MatthewsE CifrianAJ GuidrySP OliverStaphylococcus aureus invasion of bovine mammary epithelial cellsJ Dairy Sci7910211026199610.3168/jds.S0022-0302(96)76454-8

11. 

B SinhaM HerrmannMechanism and consequences of invasion of endothelial cells by Staphylococcus aureusThromb Haemost94266277200516113815

12. 

JK EllingtonSS ReillyWK RampMS SmeltzerJF KellamMC HudsonMechanisms of Staphylococcus aureus invasion of cultured osteoblastsMicrob Pathog263173231999

13. 

M JevonC GuoB MaN MordanSP NairM HarrisB HendersonG BentleyS MeghjiMechanisms of internalization of Staphylococcus aureus by cultured human osteoblastsInfect Immun67267726811999

14. 

JA WrightSP NairInteraction of staphylococci with boneInt J Med Microbiol300193204201010.1016/j.ijmm.2009.10.00319889575

15. 

JK EllingtonM HarrisMC HudsonS VishinLX WebbR SherertzIntracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitisJ Orthop Res2487932006

16. 

SS ReillyMC HudsonJF KellamWK RampIn vivo internalization of Staphylococcus aureus by embryonic chick osteoblastsBone2663702000

17. 

MJ BosseHE GruberWK RampInternalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case reportJ Bone Joint Surg Am8713431347200510.2106/JBJS.D.0264915930546

18. 

T FowlerER WannD JohS JohanssonTJ FosterM HöökCellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrinsEur J Cell Biol796726792000

19. 

H KhalilR WilliamsG StenbeckB HendersonS MeghjiS NairInvasion of bone cells by Staphylococcus epidermidisMicrobes Infect9460465200710.1016/j.micinf.2007.01.002

20. 

SP NairM BischoffMM SennB Berger-BachiThe sigma B regulon influences internalization of Staphylococcus aureus by osteoblastsInfect Immun7141674170200310.1128/IAI.71.7.4167-4170.200312819110

21. 

Q ZhangY FengQ ZhouQ LuoX ZhangL Qin[Contribution of sigma B to environmental stress tolerance in Listeria monocytogenes - a review]Wei Sheng Wu Xue Bao (In Chinese)49128212882009

22. 

MC HudsonWK RampNC NicholsonAS WilliamsMT NousiainenInternalization of Staphylococcus aureus by cultured osteoblastsMicrob Pathog194094191995

23. 

B SinhaM HerrmannMechanism and consequences of invasion of endothelial cells by Staphylococcus aureusThromb Haemost94266277200516113815

24. 

BB FinlayP CossartExploitation of mammalian host cell functions by bacterial pathogensScience276718725199710.1126/science.276.5313.7189115192

25. 

JK EllingtonA ElhofyKL BostMC HudsonInvolvement of mitogen-activated protein kinase pathways in Staphylococcus aureus invasion of normal osteoblastsInfect Immun6952355242200110.1128/IAI.69.9.5235-5242.200111500391

26. 

BJ PulvererJM KyriakisJ AvruchE NikolakakiJR WoodgettPhosphorylation of c-jun mediated by MAP kinasesNature353670674199110.1038/353670a01922387

27. 

CA RouzerT MatsumotoB SamuelssonSingle protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activitiesProc Natl Acad Sci USA83857861198610.1073/pnas.83.4.8573006030

28. 

J PaceMJ HaymanJE GalanSignal transduction and invasion of epithelial cells by S. typhimuriumCell72505514199310.1016/0092-8674(93)90070-78382566

29. 

CB WilsonRF JacobsAL SmithCellular antibiotic pharmacologySemin Perinatol62052131982

30. 

JK EllingtonM HarrisMC HudsonS VishinLX WebbR SherertzIntracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitisJ Orthop Res2487932006

31. 

JK EllingtonM HarrisL WebbIntracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitisJ Bone Joint Surg Br859189212003

32. 

I MarriottOsteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progressionImmunol Res30291308200410.1385/IR:30:3:29115531771

33. 

KL BostWK RampNC NicholsonJL BentoI MarriottMC HudsonStaphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 productionJ Infect Dis18019121920199910.1086/315138

34. 

S TrembleauT GermannMK GatelyL AdoriniThe role of IL-12 in the induction of organ-specific autoimmune diseasesImmunol Today16383386199510.1016/0167-5699(95)80006-97546194

35. 

I MarriottDL GrayDM RatiOsteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissueBone37504512200510.1016/j.bone.2005.05.01116027056

36. 

D RossiA ZlotnikThe biology of chemokines and their receptorsAnnu Rev Immunol18217242200010.1146/annurev.immunol.18.1.21710837058

37. 

NA GasperCC PettyLW SchrumI MarriottKL BostBacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4Infect Immun7040754082200210.1128/IAI.70.8.4075-4082.200212117914

38. 

KM WrightJS FriedlandRegulation of chemokine gene expression and secretion in Staphylococcus aureus-infected osteoblastsMicrobes Infect6844852200410.1016/j.micinf.2004.04.00815374006

39. 

SH McCallM SahraeiAB YoungOsteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell deathJ Bone Miner Res233040200810.1359/jbmr.071002

40. 

C JinRA FlavellMolecular mechanism of NLRP3 inflammasome activationJ Clin Immunol30628631201010.1007/s10875-010-9440-320589420

41. 

I MarriottDM RatiSH McCallSL TranguchInduction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challengeInfect Immun7329672973200510.1128/IAI.73.5.2967-2973.2005

42. 

L Le BourhisS BenkoSE GirardinNod1 and Nod2 in innate immunity and human inflammatory disordersBiochem Soc Trans35147914842007

43. 

C GiulianiG NapolitanoI BucciV MontaniF Monaco[Nf-κB transcription factor: role in the pathogenesis of inflammatory, autoimmune, and neoplastic diseases and therapy implications]Clin Ter (In Italian)1522492532001

44. 

R NingX ZhangX GuoQ LiAttachment of Staphylococcus aureus is required for activation of nuclear factor κB in human osteoblastsActa Biochim Biophys Sin (Shanghai)428838922010

45. 

KA TuckerSS ReillyCS LeslieMC HudsonIntracellular Staphylococcus aureus induces apoptosis in mouse osteoblastsFEMS Microbiol Lett1861511562000

46. 

EH AlexanderFA RiveraI MarriottJ AnguitaKL BostMC HudsonStaphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblastsBMC Microbiol35200310.1186/1471-2180-3-5

47. 

SP NairS MeghjiM WilsonK ReddiP WhiteB HendersonBacterially induced bone destruction: mechanisms and misconceptionsInfect Immun2371238019968698454

48. 

S NairY SongS MeghjiSurface-associated proteins from Staphylococcus aureus demonstrate potent bone resorbing activityJ Bone Miner Res107267341995

49. 

LC HofbauerAE HeufelderIntercellular chatter: osteoblasts, osteoclasts and interleukin 6Eur J Endocrinol134425426199610.1530/eje.0.13404258640290

50. 

I IshidaC KohdaY YanagawaH MiyaokaT ShimamuraEpigallocatechin gallate suppresses expression of receptor activator of NF-κB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cellsJ Med Microbiol56104210462007

51. 

KL BostJL BentoJK EllingtonI MarriottMC HudsonInduction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblastsInfect Immun6850755083200010.1128/IAI.68.9.5075-5083.200010948128

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi S and Zhang X: Interaction of Staphylococcus aureus with osteoblasts (Review). Exp Ther Med 3: 367-370, 2012.
APA
Shi, S., & Zhang, X. (2012). Interaction of Staphylococcus aureus with osteoblasts (Review). Experimental and Therapeutic Medicine, 3, 367-370. https://doi.org/10.3892/etm.2011.423
MLA
Shi, S., Zhang, X."Interaction of Staphylococcus aureus with osteoblasts (Review)". Experimental and Therapeutic Medicine 3.3 (2012): 367-370.
Chicago
Shi, S., Zhang, X."Interaction of Staphylococcus aureus with osteoblasts (Review)". Experimental and Therapeutic Medicine 3, no. 3 (2012): 367-370. https://doi.org/10.3892/etm.2011.423
Copy and paste a formatted citation
x
Spandidos Publications style
Shi S and Zhang X: Interaction of Staphylococcus aureus with osteoblasts (Review). Exp Ther Med 3: 367-370, 2012.
APA
Shi, S., & Zhang, X. (2012). Interaction of Staphylococcus aureus with osteoblasts (Review). Experimental and Therapeutic Medicine, 3, 367-370. https://doi.org/10.3892/etm.2011.423
MLA
Shi, S., Zhang, X."Interaction of Staphylococcus aureus with osteoblasts (Review)". Experimental and Therapeutic Medicine 3.3 (2012): 367-370.
Chicago
Shi, S., Zhang, X."Interaction of Staphylococcus aureus with osteoblasts (Review)". Experimental and Therapeutic Medicine 3, no. 3 (2012): 367-370. https://doi.org/10.3892/etm.2011.423
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team