Interaction of Staphylococcus aureus with osteoblasts (Review)

Shi,Sifeng; Zhang,Xianlong

doi:10.3892/etm.2011.423

Interaction of Staphylococcus aureus with osteoblasts (Review)

Authors:
- Sifeng Shi
- Xianlong Zhang
View Affiliations

Affiliations: Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Jiao Tong University, Shanghai, P.R. China
Published online on: December 20, 2011 https://doi.org/10.3892/etm.2011.423
Pages: 367-370

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Orthopedic infection is refractory to cure. Staphylococcus aureus (S. aureus) is the main causative pathogen responsible for orthopedic infection. S. aureus is capable of not only colonizing bone matrix, but also invading osteoblasts, which may play a significant role in the persistence and recurrence of osteomyelitis. Internalization requires the involvement of cytoskeletal elements, including actin microfilaments, microtubules and clathrin-coated pits. Microfilaments are most significant in the invasion process. S. aureus is capable of remaining alive in osteoblasts for a long period of time. Decreased sensitivity to antibiotics capable of penetrating host cells increases the difficulties of eradicating S. aureus. Osteoblasts, invaded by S. aureus, play a significant role in the initiation and maintenance of inflammatory immune responses. These osteoblasts recruit leukocytes and phagocytes to the site of inflammation via the expression of cytokines. Apoptosis is observed in osteoblasts invaded by S. aureus. Recruitment of osteoclasts and other immunocytes plays a crucial role in the resorption and destruction of bone.

View Figures

View References

1.	S ChiharaJ SegretiOsteomyelitisDis Mon56631201010.1016/j.disamonth.2009.07.001
2.	N RaoBH ZiranBA LipskyTreating osteomyelitis: antibiotics and surgeryPlast Reconstr Surg127Suppl 1S177S187201110.1097/PRS.0b013e3182001f0f
3.	G StocksHF JanssenInfection in patients after implantation of an orthopedic deviceASAIO J46S41S46200010.1097/00002480-200011000-0003611110293
4.	LX WebbW WagnerD CarrollH TylerF ColdrenE MartinOsteomyelitis and intraosteoblastic Staphylococcus aureusJ Surg Orthop Adv1673782007
5.	RA BradyGA O’MayJG LeidML PriorJW CostertonME ShirtliffResolution of Staphylococcus aureus biofilm infection using vaccination and antibiotic treatmentInfect Immun7917971803201121220484
6.	C GarzoniWL KelleyStaphylococcus aureus: new evidence for intracellular persistenceTrends Microbiol175965200910.1016/j.tim.2008.11.005
7.	S AhmedS MeghjiRJ WilliamsB HendersonJH BrockSP NairStaphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteriaInfect Immun6928722877200110.1128/IAI.69.5.2872-2877.2001
8.	EH AlexanderJL BentoFM HughesI MarriottMC HudsonKL BostStaphylococcus aureus and Salmonella enterica serovar dublin induce tumor necrosis factor-related apoptosis-inducing ligand expression by normal mouse and human osteoblastsInfect Immun6915811586200110.1128/IAI.69.3.1581-1586.2001
9.	CV GayVR GilmanT SugiyamaPerspectives on osteoblast and osteoclast functionPoult Sci7910051008200010.1093/ps/79.7.100510901202
10.	RA AlmeidaKR MatthewsE CifrianAJ GuidrySP OliverStaphylococcus aureus invasion of bovine mammary epithelial cellsJ Dairy Sci7910211026199610.3168/jds.S0022-0302(96)76454-8
11.	B SinhaM HerrmannMechanism and consequences of invasion of endothelial cells by Staphylococcus aureusThromb Haemost94266277200516113815
12.	JK EllingtonSS ReillyWK RampMS SmeltzerJF KellamMC HudsonMechanisms of Staphylococcus aureus invasion of cultured osteoblastsMicrob Pathog263173231999
13.	M JevonC GuoB MaN MordanSP NairM HarrisB HendersonG BentleyS MeghjiMechanisms of internalization of Staphylococcus aureus by cultured human osteoblastsInfect Immun67267726811999
14.	JA WrightSP NairInteraction of staphylococci with boneInt J Med Microbiol300193204201010.1016/j.ijmm.2009.10.00319889575
15.	JK EllingtonM HarrisMC HudsonS VishinLX WebbR SherertzIntracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitisJ Orthop Res2487932006
16.	SS ReillyMC HudsonJF KellamWK RampIn vivo internalization of Staphylococcus aureus by embryonic chick osteoblastsBone2663702000
17.	MJ BosseHE GruberWK RampInternalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case reportJ Bone Joint Surg Am8713431347200510.2106/JBJS.D.0264915930546
18.	T FowlerER WannD JohS JohanssonTJ FosterM HöökCellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrinsEur J Cell Biol796726792000
19.	H KhalilR WilliamsG StenbeckB HendersonS MeghjiS NairInvasion of bone cells by Staphylococcus epidermidisMicrobes Infect9460465200710.1016/j.micinf.2007.01.002
20.	SP NairM BischoffMM SennB Berger-BachiThe sigma B regulon influences internalization of Staphylococcus aureus by osteoblastsInfect Immun7141674170200310.1128/IAI.71.7.4167-4170.200312819110
21.	Q ZhangY FengQ ZhouQ LuoX ZhangL Qin[Contribution of sigma B to environmental stress tolerance in Listeria monocytogenes - a review]Wei Sheng Wu Xue Bao (In Chinese)49128212882009
22.	MC HudsonWK RampNC NicholsonAS WilliamsMT NousiainenInternalization of Staphylococcus aureus by cultured osteoblastsMicrob Pathog194094191995
23.	B SinhaM HerrmannMechanism and consequences of invasion of endothelial cells by Staphylococcus aureusThromb Haemost94266277200516113815
24.	BB FinlayP CossartExploitation of mammalian host cell functions by bacterial pathogensScience276718725199710.1126/science.276.5313.7189115192
25.	JK EllingtonA ElhofyKL BostMC HudsonInvolvement of mitogen-activated protein kinase pathways in Staphylococcus aureus invasion of normal osteoblastsInfect Immun6952355242200110.1128/IAI.69.9.5235-5242.200111500391
26.	BJ PulvererJM KyriakisJ AvruchE NikolakakiJR WoodgettPhosphorylation of c-jun mediated by MAP kinasesNature353670674199110.1038/353670a01922387
27.	CA RouzerT MatsumotoB SamuelssonSingle protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activitiesProc Natl Acad Sci USA83857861198610.1073/pnas.83.4.8573006030
28.	J PaceMJ HaymanJE GalanSignal transduction and invasion of epithelial cells by S. typhimuriumCell72505514199310.1016/0092-8674(93)90070-78382566
29.	CB WilsonRF JacobsAL SmithCellular antibiotic pharmacologySemin Perinatol62052131982
30.	JK EllingtonM HarrisMC HudsonS VishinLX WebbR SherertzIntracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitisJ Orthop Res2487932006
31.	JK EllingtonM HarrisL WebbIntracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitisJ Bone Joint Surg Br859189212003
32.	I MarriottOsteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progressionImmunol Res30291308200410.1385/IR:30:3:29115531771
33.	KL BostWK RampNC NicholsonJL BentoI MarriottMC HudsonStaphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 productionJ Infect Dis18019121920199910.1086/315138
34.	S TrembleauT GermannMK GatelyL AdoriniThe role of IL-12 in the induction of organ-specific autoimmune diseasesImmunol Today16383386199510.1016/0167-5699(95)80006-97546194
35.	I MarriottDL GrayDM RatiOsteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissueBone37504512200510.1016/j.bone.2005.05.01116027056
36.	D RossiA ZlotnikThe biology of chemokines and their receptorsAnnu Rev Immunol18217242200010.1146/annurev.immunol.18.1.21710837058
37.	NA GasperCC PettyLW SchrumI MarriottKL BostBacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4Infect Immun7040754082200210.1128/IAI.70.8.4075-4082.200212117914
38.	KM WrightJS FriedlandRegulation of chemokine gene expression and secretion in Staphylococcus aureus-infected osteoblastsMicrobes Infect6844852200410.1016/j.micinf.2004.04.00815374006
39.	SH McCallM SahraeiAB YoungOsteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell deathJ Bone Miner Res233040200810.1359/jbmr.071002
40.	C JinRA FlavellMolecular mechanism of NLRP3 inflammasome activationJ Clin Immunol30628631201010.1007/s10875-010-9440-320589420
41.	I MarriottDM RatiSH McCallSL TranguchInduction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challengeInfect Immun7329672973200510.1128/IAI.73.5.2967-2973.2005
42.	L Le BourhisS BenkoSE GirardinNod1 and Nod2 in innate immunity and human inflammatory disordersBiochem Soc Trans35147914842007
43.	C GiulianiG NapolitanoI BucciV MontaniF Monaco[Nf-κB transcription factor: role in the pathogenesis of inflammatory, autoimmune, and neoplastic diseases and therapy implications]Clin Ter (In Italian)1522492532001
44.	R NingX ZhangX GuoQ LiAttachment of Staphylococcus aureus is required for activation of nuclear factor κB in human osteoblastsActa Biochim Biophys Sin (Shanghai)428838922010
45.	KA TuckerSS ReillyCS LeslieMC HudsonIntracellular Staphylococcus aureus induces apoptosis in mouse osteoblastsFEMS Microbiol Lett1861511562000
46.	EH AlexanderFA RiveraI MarriottJ AnguitaKL BostMC HudsonStaphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblastsBMC Microbiol35200310.1186/1471-2180-3-5
47.	SP NairS MeghjiM WilsonK ReddiP WhiteB HendersonBacterially induced bone destruction: mechanisms and misconceptionsInfect Immun2371238019968698454
48.	S NairY SongS MeghjiSurface-associated proteins from Staphylococcus aureus demonstrate potent bone resorbing activityJ Bone Miner Res107267341995
49.	LC HofbauerAE HeufelderIntercellular chatter: osteoblasts, osteoclasts and interleukin 6Eur J Endocrinol134425426199610.1530/eje.0.13404258640290
50.	I IshidaC KohdaY YanagawaH MiyaokaT ShimamuraEpigallocatechin gallate suppresses expression of receptor activator of NF-κB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cellsJ Med Microbiol56104210462007
51.	KL BostJL BentoJK EllingtonI MarriottMC HudsonInduction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblastsInfect Immun6850755083200010.1128/IAI.68.9.5075-5083.200010948128