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Article

Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma

  • Authors:
    • Zhanjun Guo
    • Hua Yang
    • Cuiju Wang
    • Shufeng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 499-502
    |
    Published online on: December 27, 2011
       https://doi.org/10.3892/etm.2011.434
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Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been associated with various types of cancer. The association of SNPs with cancer risk and disease outcome has been exhaustively studied. In this study, we investigated the association of age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of hepatocellular carcinoma (HCC) patients. Haplogroup M (489C) and allele 235G were identified for their association with the late onset of HCC by the log-rank test. In an overall multivariate analysis, haplogroup M (489C) was identified as an independent predictive factor for the age-at-onset of HCC at borderline significant levels [relative risk, 1.736; 95% confidence interval (CI), 0.967-3.115; p=0.065]. Genetic polymorphisms in the D-loop are predictive markers for age‑at-onset in HCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help to identify HCC patient subgroups at high risk of early onset of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, Yang H, Wang C and Liu S: Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Exp Ther Med 3: 499-502, 2012.
APA
Guo, Z., Yang, H., Wang, C., & Liu, S. (2012). Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3, 499-502. https://doi.org/10.3892/etm.2011.434
MLA
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3.3 (2012): 499-502.
Chicago
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3, no. 3 (2012): 499-502. https://doi.org/10.3892/etm.2011.434
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, Yang H, Wang C and Liu S: Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Exp Ther Med 3: 499-502, 2012.
APA
Guo, Z., Yang, H., Wang, C., & Liu, S. (2012). Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3, 499-502. https://doi.org/10.3892/etm.2011.434
MLA
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3.3 (2012): 499-502.
Chicago
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3, no. 3 (2012): 499-502. https://doi.org/10.3892/etm.2011.434
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