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Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma

  • Authors:
    • Zhanjun Guo
    • Hua Yang
    • Cuiju Wang
    • Shufeng Liu

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  • Published online on: December 27, 2011     https://doi.org/10.3892/etm.2011.434
  • Pages: 499-502
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Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been associated with various types of cancer. The association of SNPs with cancer risk and disease outcome has been exhaustively studied. In this study, we investigated the association of age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of hepatocellular carcinoma (HCC) patients. Haplogroup M (489C) and allele 235G were identified for their association with the late onset of HCC by the log-rank test. In an overall multivariate analysis, haplogroup M (489C) was identified as an independent predictive factor for the age-at-onset of HCC at borderline significant levels [relative risk, 1.736; 95% confidence interval (CI), 0.967-3.115; p=0.065]. Genetic polymorphisms in the D-loop are predictive markers for age‑at-onset in HCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help to identify HCC patient subgroups at high risk of early onset of the disease.
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March 2012
Volume 3 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Guo Z, Yang H, Wang C and Liu S: Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Exp Ther Med 3: 499-502, 2012
APA
Guo, Z., Yang, H., Wang, C., & Liu, S. (2012). Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma. Experimental and Therapeutic Medicine, 3, 499-502. https://doi.org/10.3892/etm.2011.434
MLA
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3.3 (2012): 499-502.
Chicago
Guo, Z., Yang, H., Wang, C., Liu, S."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma". Experimental and Therapeutic Medicine 3, no. 3 (2012): 499-502. https://doi.org/10.3892/etm.2011.434