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Article

No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis

  • Authors:
    • Dawei Li
    • Tian Tian
    • Chunhui Guo
    • Juchao Ren
    • Lei Yan
    • Hainan Liu
    • Zhonghua Xu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Tuberculosis, Tuberculosis Hospital of Binzhou City, Binzhou, Shandong 251700, P.R. China, Department of Oncology, Tuberculosis Hospital of Binzhou City, Binzhou, Shandong 251700, P.R. China
  • Pages: 493-498
    |
    Published online on: January 4, 2012
       https://doi.org/10.3892/etm.2012.445
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Abstract

Various studies have demonstrated that the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism contributes to the risk of prostate cancer, while other studies have provided conflicting findings. In the present study, we carried out a comprehensive meta-analysis with the aim of determining whether there is a significant association of the MTHFR gene A1298C polymorphism with the susceptibility of prostate cancer. Studies on the MTHFR gene A1298C polymorphism and prostate cancer were retrieved using the electronic PubMed database without any restriction on language through Aug 21, 2011. Data were abstracted by a standardized protocol. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association. The analyses were conducted with Review Manager software version 4.2. Nine case-control studies were identified, including 2,723 prostate cancer patients and 3,442 controls. Overall, no significant associations were found between the MTHFR gene A1298C polymorphism and prostate cancer (codominant models: CC vs. AA, OR=1.03, 95% CI 0.79-1.34, P=0.84; AC vs. AA, OR=1.04, 95% CI 0.93-1.16, P=0.46; dominant model: AC + CC vs. AA, OR=1.04, 95% CI 0.94-1.15, P=0.48; recessive model: CC vs. AC + AA, OR=1.02, 95% CI 0.76-1.35, P=0.91; allele model: C vs. A, OR=1.04, 95% CI 0.90-1.19, P=0.61). Similarly, in the subgroup analyses by DNA source, ethnicity, control source, pathological stage and Hardy-Weinberg equilibrium, no significant associations were observed. Our meta-analysis suggests that the MTHFR gene A1298C polymorphism is not associated with the risk of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li D, Tian T, Guo C, Ren J, Yan L, Liu H and Xu Z: No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis. Exp Ther Med 3: 493-498, 2012.
APA
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., & Xu, Z. (2012). No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis. Experimental and Therapeutic Medicine, 3, 493-498. https://doi.org/10.3892/etm.2012.445
MLA
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., Xu, Z."No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis". Experimental and Therapeutic Medicine 3.3 (2012): 493-498.
Chicago
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., Xu, Z."No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis". Experimental and Therapeutic Medicine 3, no. 3 (2012): 493-498. https://doi.org/10.3892/etm.2012.445
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Tian T, Guo C, Ren J, Yan L, Liu H and Xu Z: No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis. Exp Ther Med 3: 493-498, 2012.
APA
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., & Xu, Z. (2012). No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis. Experimental and Therapeutic Medicine, 3, 493-498. https://doi.org/10.3892/etm.2012.445
MLA
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., Xu, Z."No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis". Experimental and Therapeutic Medicine 3.3 (2012): 493-498.
Chicago
Li, D., Tian, T., Guo, C., Ren, J., Yan, L., Liu, H., Xu, Z."No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis". Experimental and Therapeutic Medicine 3, no. 3 (2012): 493-498. https://doi.org/10.3892/etm.2012.445
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