Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April 2012 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2012 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases

  • Authors:
    • Yi-Shan Wang
    • Yuan-Yuan Wang
    • Peng Jiang
    • Jian-Jun Ma
    • Zhen Qu
    • Xi-Lin Wang
    • Jun-Ti Li
    • Xi-Feng Jia
  • View Affiliations / Copyright

    Affiliations: Center for Tumor Treatment, The People's Liberation Army 107th Hospital, Shandong 264002, P.R. China
  • Pages: 725-727
    |
    Published online on: January 12, 2012
       https://doi.org/10.3892/etm.2012.451
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The objective of the present study was to evaluate short-term outcomes of CyberKnife therapy in patients with advanced high-risk tumors. A total of 201 target areas from 341 advanced high-risk tumor lesions in 160 patients were treated with CyberKnife. A prescribed dose of 18-60 Gy to the gross tumor volume was delivered in 1-6 fractions to complete the entire treatment in 1 week. Radiographic studies and clinical examinations were performed at 1- to 3-month follow‑up intervals, and the results were compared to outcomes of 160 similar advanced high-risk tumor patients who were treated by conformal radiotherapy (CRT). After CyberKnife therapy, the short-term improvement in the quality of life was significant according to radiographic study, radioimmunoassay and ZPS scores of these patients. The total rates of objective efficacy and alleviation of ascities were as high as 66.88 and 67.90%. The short-term outcomes in our series of patients with advanced high-risk tumors treated with CyberKnife appeared to be better compared to conventional CRT. CyberKnife may be an option for patients with incurable advanced high-risk tumors, although further studies of the long-term outcomes are required to confirm the validity.
View Figures

Figure 1

View References

1. 

Chang BK and Timmerman RD: Stereotactic body radiation therapy: a comprehensive review. Am J Clin Oncol. 30:637–644. 2007. View Article : Google Scholar : PubMed/NCBI

2. 

Shirato H, Shimizu S, Kitamura K and Onimaru R: Organ motion in image-guided radiotherapy: lessons from real-time tumor tracking radiotherapy. Int J Clin Oncol. 12:8–16. 2007. View Article : Google Scholar : PubMed/NCBI

3. 

Dewas S, Dewas-Vautravers C, Servent V, et al: Results and special considerations when treating elderly patients with CyberKnife: a review of 345 cases. Crit Rev Oncol Hematol. 76:1–7. 2010.PubMed/NCBI

4. 

Brown WT, Wu X, Wen BC, et al: Early results of CyberKnife image-guided robotic stereotactic radiosurgery for treatment of lung tumors. Comput Aided Surg. 12:253–261. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Bucholz RD, Laycock KA and Cuff LE: CyberKnife stereo-tactic radiosurgery for intracranial neoplasms, with a focus on malignant tumors. Technol Cancer Res Treat. 9:541–550. 2010. View Article : Google Scholar : PubMed/NCBI

6. 

Nagata Y, Matsuo Y, Takayama K, et al: Current status of stereo-tactic body radiotherapy for lung cancer. Int J Clin Oncol. 12:3–7. 2007. View Article : Google Scholar

7. 

Yamazaki H, Shiomi H, Tsubokura T, et al: Quantitative assessment of inter-observer variability in target volume delineation on stereotactic radiotherapy treatment for pituitary adenoma and meningioma optic tract. Radiat Oncol. 6:102011.

8. 

Hasney CP, Swanton RG and Friendlander PL: CyberKnife stereotactic radiosurgery for recurrent squamous cell carcinoma of the head and neck following salvage surgery with close or positive margins. Laryngoscope. 4:1522010. View Article : Google Scholar : PubMed/NCBI

9. 

Oermann EK, Slack RS, Hanscom HN, et al: A pilot study of intensity modulated radiation therapy with hypofractionated stereotactic body radiation therapy (SBRT) boost in the treatment of intermediate to high-risk prostate cancer. Technol Cancer Res Treat. 9:453–462. 2010. View Article : Google Scholar : PubMed/NCBI

10. 

Unger F, Dominikus K and Haselsberger K: Stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neuromas. HNO. 59:31–37. 2011.(In German).

11. 

Alongi F and Di Muzio N: Image-guided radiation therapy: A new era for the radiation oncologist? Int J Clin Oncol. 14:568–569. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Schweikard A, Shiomi H and Adler J: Respiration tracking in radiosurgery. Med Phys. 31:2738–2741. 2004. View Article : Google Scholar

13. 

Jereczed-Fossa BA, Beltramo G, Fariselli L, et al: Robotic image-guided stereotactic radiotherapy, for isolated recurrent primary, lymph node or metastatic prostate cancer. Int J Radiat Oncol Biol Phys. 79:1–9. 2011.PubMed/NCBI

14. 

Reichner C, Collins B, Gagnon G, et al: The placement of gold fiducials for cyberknife stereotactic radiosurgery using a modified transbronchial needle aspiration technique. J Bronchol. 12:193–195. 2005. View Article : Google Scholar

15. 

Collins BT, Erickson K, Reichner CA, et al: Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors. Radiat Oncol. 2:392007. View Article : Google Scholar : PubMed/NCBI

16. 

Hashizume M: MRI-guided laparoscopic and robotic surgery for malignancies. Int J Clin Oncol. 12:94–98. 2007. View Article : Google Scholar : PubMed/NCBI

17. 

Roh KW, Jang JS, Kim MS, et al: Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer. Int J Radiat Onc Biol Phys. 74:1348–1355. 2009. View Article : Google Scholar

18. 

King CR, Brooks JD, Gill H, et al: Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys. 73:1043–1048. 2009. View Article : Google Scholar : PubMed/NCBI

19. 

Brown WT, Fayad F, Hevezi J, et al: Individualized higher dose of 70–75 Gy using five-fraction robotic stereotactic radiotherapy for non-small-cell lung cancer: a feasibility study. Comput Aided Surg. 16:1–10. 2011.

20. 

Vavassori A, Jereczek-Fossa BA, Beltramo G, et al: Image-guided robotic radiosurgery as salvage therapy for locally recurrent prostate cancer after external beam irradiation: retrospective feasibility study on six cases. Tumori. 96:71–75. 2010.

21. 

Yoshioka Y: Current status and perspectives of brachytherapy for prostate cancer. Int J Clin Oncol. 14:31–36. 2009. View Article : Google Scholar : PubMed/NCBI

22. 

Thariat J, Li G, Angellier G, et al: Current indications and ongoing clinical trials with CyberKnife stereotactic radiotherapy in France in 2009. Bull Cancer. 96:853–864. 2009.PubMed/NCBI

23. 

Xie Y, Djajaputra D, King CR, et al: Intrafractional motion of the prostate during hypofractionated radiotherapy. Int J Radiat Oncol Biol Phys. 72:236–246. 2008. View Article : Google Scholar : PubMed/NCBI

24. 

Fowler JF, Welsh JS, Howard SP, et al: Loss of biological effect in prolonged fraction delivery. Int J Radiat Oncol Biol Phys. 159:242–249. 2004. View Article : Google Scholar : PubMed/NCBI

25. 

Fuller DB, Naitoh J, Lee C, et al: Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations. Int J Radiat Oncol Biol Phys. 70:1588–1597. 2008. View Article : Google Scholar

26. 

Naito S: Recent developments and perspectives of image-guided precision surgery for malignant. Int J Clin Oncol. 12:69–70. 2007. View Article : Google Scholar

27. 

Hara W, Loo BW, Goffinet DR, et al: Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 71:393–400. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang Y, Jiang P, Ma J, Qu Z, Wang X, Li J and Jia X: Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases. Exp Ther Med 3: 725-727, 2012.
APA
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X. ... Jia, X. (2012). Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases. Experimental and Therapeutic Medicine, 3, 725-727. https://doi.org/10.3892/etm.2012.451
MLA
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X., Li, J., Jia, X."Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases". Experimental and Therapeutic Medicine 3.4 (2012): 725-727.
Chicago
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X., Li, J., Jia, X."Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases". Experimental and Therapeutic Medicine 3, no. 4 (2012): 725-727. https://doi.org/10.3892/etm.2012.451
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang Y, Jiang P, Ma J, Qu Z, Wang X, Li J and Jia X: Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases. Exp Ther Med 3: 725-727, 2012.
APA
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X. ... Jia, X. (2012). Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases. Experimental and Therapeutic Medicine, 3, 725-727. https://doi.org/10.3892/etm.2012.451
MLA
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X., Li, J., Jia, X."Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases". Experimental and Therapeutic Medicine 3.4 (2012): 725-727.
Chicago
Wang, Y., Wang, Y., Jiang, P., Ma, J., Qu, Z., Wang, X., Li, J., Jia, X."Short-term outcomes of CyberKnife therapy for advanced high-risk tumors: A report of 160 cases". Experimental and Therapeutic Medicine 3, no. 4 (2012): 725-727. https://doi.org/10.3892/etm.2012.451
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team