Correlation of polymorphisms of the vascular endothelial growth factor gene and the risk of lung cancer in an ethnic Han group of North China

Li,Yan; Liang,Jing; Liu,Xiaolin; Liu,Hairong; Yin,Beibei; Xiao,Junjuan; Bi,Zhenqiang

doi:10.3892/etm.2012.453

April 2012 Volume 3 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April 2012 Volume 3 Issue 4

Full Size Image

Article

Correlation of polymorphisms of the vascular endothelial growth factor gene and the risk of lung cancer in an ethnic Han group of North China

Authors:
- Yan Li
- Jing Liang
- Xiaolin Liu
- Hairong Liu
- Beibei Yin
- Junjuan Xiao
- Zhenqiang Bi
View Affiliations / Copyright

Affiliations: Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China, Shandong Center for Disease Control and Prevention, Jinan, Shandong 250014, P.R. China
Pages: 673-676
|
Published online on: January 13, 2012

https://doi.org/10.3892/etm.2012.453
Expand metrics +

Abstract

Vascular endothelial growth factor (VEGF) is a potent angiogenic mediator. The present study investigated the relationship between genetic polymorphisms of VEGF and susceptibility to lung cancer in a Han ethnic group of North China. The genotypes in the -2578C and 936C loci of VEGF gene were determined using PCR-RFLP method in 150 patients with lung cancers and 150 healthy individuals. Software PHASE 1.0 was used to analyze the experimental data. The non-conditional logistic regression model was used to analyze the statistical association of genotypes and susceptibility in the two groups adjusted by multiple factors. VEGF polymorphisms were found to be a critical risk for the genetic susceptibility to lung cancers in the ethnic Han group of North China. SNP polymorphisms at the -2578C and 936C loci of the VEGF gene were detected by the RFLP-PCR method. High rates of a single-base C-to-A alteration at the -2578 locus and high rates of a single-base C-to-T alteration at the 936 locus of both alleles were correlated with the occurrence of lung cancer. The SNP markers at the -2578C and 936C loci of the VEGF gene may serve as biological markers of lung cancer.

View Figures

View References

1.	Shibuya M and Claesson-Welsh L: Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 312:549–560. 2006. View Article : Google Scholar : PubMed/NCBI
2.	Gotink KJ and Verheul HMW: Antiangiogenic tyrosine kinase inhibitors: What is their mechanism of action? Angiogenesis. 13:1–14. 2010. View Article : Google Scholar : PubMed/NCBI
3.	O’Byrne KJ, Koukourakis MI, Giatromanolaki A, et al: Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small cell cancer. Br J Cancer. 82:1427–1432. 2000.PubMed/NCBI
4.	Lee SJ, Lee SY, Jeon HS, et al: Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 14:571–575. 2005. View Article : Google Scholar : PubMed/NCBI
5.	Baillie R, Harada K, Carlile J, Macluskey M, Schor SL and Schor AM: Expression of vascular endothelial growth factor in normal and tumor oral tissues with different antibodies. Histochem J. 33:287–294. 2001. View Article : Google Scholar : PubMed/NCBI
6.	Salven P, Ruotsalainen T, Mattson K and Joensuu H: High pretreatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int J Cancer. 79:144–146. 2000. View Article : Google Scholar : PubMed/NCBI
7.	Sheng H, Aoe M, Doihara H, Andou A and Shimizu N: Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma. Acta Med Okayama. 54:119–126. 2000.PubMed/NCBI
8.	Yuan A, Yu CJ, Chen WJ, Lin FY, Kuo SH, Luh KT and Yang PC: Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small cell lung cancer. Int J Cancer. 89:475–483. 2000. View Article : Google Scholar : PubMed/NCBI
9.	Oshika Y, Nakamura M, Tokunaga T, et al: Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer. Int J Oncol. 12:541–544. 1998.PubMed/NCBI
10.	Collins FS, Patrinos A, Jordan E, Chakravarti A, Gesteland R and Walters L: New goals for the U.S. Human Genome Project: 1998–2003. Science. 282:682–689. 1998.PubMed/NCBI
11.	Wang DG, Fan JB, Siao CJ, et al: Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 280:1077–1082. 1998. View Article : Google Scholar : PubMed/NCBI
12.	Roses AD: Pharmacogenetics and the practice of medicine. Nature. 405:857–865. 2000. View Article : Google Scholar : PubMed/NCBI
13.	Kruglyak L and Nickerson DA: Variation is the spice of life. Nat Genet. 27:234–236. 2001. View Article : Google Scholar
14.	Przeworski M, Hudson RR and di Rienzo A: Adjusting the focus on human variation. Trends Genet. 16:296–302. 2000. View Article : Google Scholar
15.	Jacobs EJ, Feigelson HS, Bain EB, et al: Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort. Breast Cancer Res. 8:222006. View Article : Google Scholar : PubMed/NCBI
16.	Jin Q, Hemminki K, Enquist K, et al: Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer Res. 11:3647–3653. 2005. View Article : Google Scholar : PubMed/NCBI
17.	Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B and Pilger E: A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res. 37:443–448. 2000. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation of polymorphisms of the vascular endothelial growth factor gene and the risk of lung cancer in an ethnic Han group of North China

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles