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Article

Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals

  • Authors:
    • Reng-Yun Liu
    • Xiaoxue Song
    • Ping Chen
    • Zhe Lei
    • Jingcheng Miao
    • Nengjun Yi
    • Kui Zhang
    • Boris Pasche
    • Hong-Tao Zhang
  • View Affiliations / Copyright

    Affiliations: Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China, Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, FIN-00014, Finland, Department of Cellular and Molecular Biology, Medical College of Soochow University, Suzhou 215123, P.R. China, Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA, Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, NP 2566 Birmingham, AL 35294-3300, USA
  • Pages: 655-664
    |
    Published online on: January 13, 2012
       https://doi.org/10.3892/etm.2012.454
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Abstract

Interleukin-6 (IL6) is a pleiotropic inflammatory cytokine, which is implicated in the development and progression of several types of cancer. The -174G/C polymorphism of the IL6 gene controls serum levels of IL6 and may be associated with cancer risk, but the results from the published studies on the association between this polymorphism and cancer risk are conflicting. A comprehensive meta-analysis was conducted to assess the association of IL6 -174G/C with cancer risk. Studies were identified by searches of MEDLINE and HuGE Published Literature databases, with no restrictions. An eligible 83 articles involving 44,735 cancer patients and 60,747 controls were included. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association between the IL6 -174 G/C polymorphism and cancer risk. Potential sources of heterogeneity were explored by meta-regression and sensitivity analysis. Overall, the IL6 -174G/C polymorphism was not significantly associated with cancer risk. However, cancer risk was increased for individuals with the CC genotype compared to those carrying the GG genotype in African populations (OR=1.83, 95% CI 1.26-2.67, P=0.002), but not in Caucasian populations (OR=1.00, 95% CI 0.92-1.08, P=0.938). The present meta-analysis provides the first evidence of the ethnic-specific association of the IL6 -174G/C polymorphism with cancer risk. Further investigations with a large number of cases and controls are required to confirm the associations between this polymorphism and cancer in Africans.
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Copy and paste a formatted citation
Spandidos Publications style
Liu R, Song X, Chen P, Lei Z, Miao J, Yi N, Zhang K, Pasche B and Zhang H: Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals. Exp Ther Med 3: 655-664, 2012.
APA
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N. ... Zhang, H. (2012). Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals. Experimental and Therapeutic Medicine, 3, 655-664. https://doi.org/10.3892/etm.2012.454
MLA
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N., Zhang, K., Pasche, B., Zhang, H."Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals". Experimental and Therapeutic Medicine 3.4 (2012): 655-664.
Chicago
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N., Zhang, K., Pasche, B., Zhang, H."Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals". Experimental and Therapeutic Medicine 3, no. 4 (2012): 655-664. https://doi.org/10.3892/etm.2012.454
Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Song X, Chen P, Lei Z, Miao J, Yi N, Zhang K, Pasche B and Zhang H: Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals. Exp Ther Med 3: 655-664, 2012.
APA
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N. ... Zhang, H. (2012). Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals. Experimental and Therapeutic Medicine, 3, 655-664. https://doi.org/10.3892/etm.2012.454
MLA
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N., Zhang, K., Pasche, B., Zhang, H."Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals". Experimental and Therapeutic Medicine 3.4 (2012): 655-664.
Chicago
Liu, R., Song, X., Chen, P., Lei, Z., Miao, J., Yi, N., Zhang, K., Pasche, B., Zhang, H."Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals". Experimental and Therapeutic Medicine 3, no. 4 (2012): 655-664. https://doi.org/10.3892/etm.2012.454
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