Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma

  • Authors:
    • Y.P Liu
    • B.E. Shan
    • X.L. Wang
    • L. Ma
  • View Affiliations

  • Published online on: February 7, 2012     https://doi.org/10.3892/etm.2012.475
  • Pages: 745-749
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Abstract

The aim of this study was to clarify the clinicopathological outcome and prognostic significance of metastasis-associated gene 2 (MTA2) in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining for MTA2 was performed on surgical specimens obtained from 162 patients with ESCC. Relationships between MTA2 expression and clinicopathological factors, including prognosis, were analyzed. Significant correlations were noted among MTA2 overexpression and TNM clinical classification staging, depth of invasion, presence of regional lymph node metastasis, presence of distant metastasis, lymphatic invasion, blood-vessel invasion and the 5-year survival rates. The expression of MTA2 protein was correlated with tumour progression. Patients with MTA2 overexpression tended to have poor prognosis compared to patients with MTA2 underexpression.
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April 2012
Volume 3 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Y, Shan B, Wang X and Ma L: Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma. Exp Ther Med 3: 745-749, 2012
APA
Liu, Y., Shan, B., Wang, X., & Ma, L. (2012). Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 3, 745-749. https://doi.org/10.3892/etm.2012.475
MLA
Liu, Y., Shan, B., Wang, X., Ma, L."Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 3.4 (2012): 745-749.
Chicago
Liu, Y., Shan, B., Wang, X., Ma, L."Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 3, no. 4 (2012): 745-749. https://doi.org/10.3892/etm.2012.475