Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma

Liu,Y.P; Shan,B.E.; Wang,X.L.; Ma,L.

doi:10.3892/etm.2012.475

April 2012 Volume 3 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April 2012 Volume 3 Issue 4

Full Size Image

Article

Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma

Authors:
- Y.P Liu
- B.E. Shan
- X.L. Wang
- L. Ma
View Affiliations / Copyright

Affiliations: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Scientific Research Center, Institute of the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Surgery, Institute of the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
Pages: 745-749
|
Published online on: February 7, 2012

https://doi.org/10.3892/etm.2012.475
Expand metrics +

Abstract

The aim of this study was to clarify the clinicopathological outcome and prognostic significance of metastasis-associated gene 2 (MTA2) in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining for MTA2 was performed on surgical specimens obtained from 162 patients with ESCC. Relationships between MTA2 expression and clinicopathological factors, including prognosis, were analyzed. Significant correlations were noted among MTA2 overexpression and TNM clinical classification staging, depth of invasion, presence of regional lymph node metastasis, presence of distant metastasis, lymphatic invasion, blood-vessel invasion and the 5-year survival rates. The expression of MTA2 protein was correlated with tumour progression. Patients with MTA2 overexpression tended to have poor prognosis compared to patients with MTA2 underexpression.

View Figures

View References

1.	Shappell SB, Olson SJ, Hannah SE, et al: Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. Cancer Res. 63:2256–2267. 2003.PubMed/NCBI
2.	Toh Y, Kuninaka S, Endo K, et al: Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1. J Exp Clin Cancer Res. 19:105–111. 2000.PubMed/NCBI
3.	Cui Y, Niu A, Pestell R, et al: Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol. 20:2020–2035. 2006. View Article : Google Scholar
4.	Nicolson GL, Nawa A, Toh Y, et al: Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis. 20:19–24. 2003. View Article : Google Scholar : PubMed/NCBI
5.	Saito M and Ishikawa F: The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem. 277:35434–35439. 2002. View Article : Google Scholar : PubMed/NCBI
6.	Wong JJ, Hawkins NJ and Ward RL: Colorectal cancer: a model for epigenetic tumorigenesis. Gut. 56:140–148. 2007. View Article : Google Scholar : PubMed/NCBI
7.	Yao YL and Yang WM: The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J Biol Chem. 278:42560–42568. 2003. View Article : Google Scholar : PubMed/NCBI
8.	Kumar R, Wang RA and Bagheri-Yarmand R: Emerging roles of MTA family members in human cancers. Semin Oncol. 30:30–37. 2003. View Article : Google Scholar : PubMed/NCBI
9.	Liu YP, Ma L, Wang SJ, et al: Prognostic value of lymph node metastases and lymph node ratio in esophageal squamous cell carcinoma. EJSO. 36:155–159. 2010. View Article : Google Scholar : PubMed/NCBI
10.	Zhang H, Stephens C and Kumar R: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res. 12:1479–1486. 2006. View Article : Google Scholar : PubMed/NCBI
11.	Fujita N, Kajita M, Taysavang P, et al: Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. Mol Endocrinol. 18:2937–2949. 2004. View Article : Google Scholar : PubMed/NCBI
12.	Park SI, Zhang J, Phillips KA, et al: Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res. 68:3323–3333. 2008. View Article : Google Scholar : PubMed/NCBI
13.	Manavathi B, Singh K and Kumar R: MTA family of coregulators in nuclear receptor biology and pathology. Nucl Recept Signal. 5:e0102007.PubMed/NCBI
14.	Li W, Zhang J, Liu X, Xu R and Zhang Y: Correlation of appearance of metastasis-associated protein1 (Mta1) with spermatogenesis in developing mouse testis. Cell Tissue Res. 329:351–362. 2007. View Article : Google Scholar : PubMed/NCBI
15.	Adjei AA: Pemetrexed in the treatment of selected solid tumors. Semin Oncol. 29:50–53. 2002. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles