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Article

Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population

  • Authors:
    • Hua Yuan
    • Huizhang Li
    • Hongxia Ma
    • Yuming Niu
    • Yunong Wu
    • Shangyue Zhang
    • Zhibin Hu
    • Hongbing Shen
    • Ning Chen
  • View Affiliations / Copyright

    Affiliations: Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Huai'an No. 1 Hospital, Huai'an, Jiangsu 223300, P.R. China
  • Pages: 719-724
    |
    Published online on: February 9, 2012
       https://doi.org/10.3892/etm.2012.476
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Abstract

Although tobacco and alcohol consumption are the major risk factors of head and neck cancer (HNC), genetic variations of genes involved in several biological pathways, such as DNA repair genes, may affect an individual's susceptibility to HNC. However, few studies have investigated the associations between polymorphisms in DNA repair genes and HNC risk in the Chinese population. Thus, we genotyped five common, non-synonymous single-nucleotide polymorphisms (SNPs) [APEX1 (Asp148Glu), XRCC1 (Arg399Gln), ADPRT (Val762Ala), XPD (Lys751Gln) and XPG (His1104Asp)] in a hospital-based, case-control study of 397 HNC cases and 900 cancer-free controls in China. The results showed that none of the five SNPs in the DNA repair pathway was significantly associated with HNC risk, suggesting that these polymorphisms may not play a major role in HNC susceptibility in this Chinese population.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan H, Li H, Ma H, Niu Y, Wu Y, Zhang S, Hu Z, Shen H and Chen N: Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Exp Ther Med 3: 719-724, 2012.
APA
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S. ... Chen, N. (2012). Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Experimental and Therapeutic Medicine, 3, 719-724. https://doi.org/10.3892/etm.2012.476
MLA
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S., Hu, Z., Shen, H., Chen, N."Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population". Experimental and Therapeutic Medicine 3.4 (2012): 719-724.
Chicago
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S., Hu, Z., Shen, H., Chen, N."Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population". Experimental and Therapeutic Medicine 3, no. 4 (2012): 719-724. https://doi.org/10.3892/etm.2012.476
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan H, Li H, Ma H, Niu Y, Wu Y, Zhang S, Hu Z, Shen H and Chen N: Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Exp Ther Med 3: 719-724, 2012.
APA
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S. ... Chen, N. (2012). Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Experimental and Therapeutic Medicine, 3, 719-724. https://doi.org/10.3892/etm.2012.476
MLA
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S., Hu, Z., Shen, H., Chen, N."Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population". Experimental and Therapeutic Medicine 3.4 (2012): 719-724.
Chicago
Yuan, H., Li, H., Ma, H., Niu, Y., Wu, Y., Zhang, S., Hu, Z., Shen, H., Chen, N."Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population". Experimental and Therapeutic Medicine 3, no. 4 (2012): 719-724. https://doi.org/10.3892/etm.2012.476
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