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Article

Sodium aescinate ameliorates liver injury induced by methyl parathion in rats

  • Authors:
    • Yuan Du
    • Tian Wang
    • Na Jiang
    • Ru-Tong Ren
    • Chong Li
    • Chang-Kun Li
    • Feng-Hua Fu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China
  • Pages: 818-822
    |
    Published online on: February 13, 2012
       https://doi.org/10.3892/etm.2012.479
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Abstract

Methyl parathion, a highly cytotoxic insecticide, has been used in agricultural pest control for several years. The present study investigated the protective effect of sodium aescinate (SA, the sodium salt of aescin) against liver injury induced by methyl parathion. Forty male Sprague-Dawley rats were randomly divided into 5 groups of 8 animals: the control group; the methyl parathion (15 mg/kg) poisoning (MP) group; and the MP plus SA at doses of 0.45, 0.9 and 1.8 mg/kg groups. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and acetylcholinesterase (AChE) in the plasma were assayed. Nitric oxide (NO) and antioxidative parameters were measured. Histopathological examination of the liver was also performed. The results revealed that SA had no effect on AChE. Treatment with SA decreased the activities of ALT and AST, and the levels of malondialdehyde and NO. Treatment with SA also increased the level of glutathione and the activities of superoxide dismutase and glutathione peroxidase. SA administration also ameliorated liver injury induced by methyl parathion poisoning. The findings indicate that SA protects against liver injury induced by methyl parathion and that the mechanism of action is related to the antioxidative and anti-inflammatory effects of SA.
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Copy and paste a formatted citation
Spandidos Publications style
Du Y, Wang T, Jiang N, Ren R, Li C, Li C and Fu F: Sodium aescinate ameliorates liver injury induced by methyl parathion in rats. Exp Ther Med 3: 818-822, 2012.
APA
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., & Fu, F. (2012). Sodium aescinate ameliorates liver injury induced by methyl parathion in rats. Experimental and Therapeutic Medicine, 3, 818-822. https://doi.org/10.3892/etm.2012.479
MLA
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., Fu, F."Sodium aescinate ameliorates liver injury induced by methyl parathion in rats". Experimental and Therapeutic Medicine 3.5 (2012): 818-822.
Chicago
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., Fu, F."Sodium aescinate ameliorates liver injury induced by methyl parathion in rats". Experimental and Therapeutic Medicine 3, no. 5 (2012): 818-822. https://doi.org/10.3892/etm.2012.479
Copy and paste a formatted citation
x
Spandidos Publications style
Du Y, Wang T, Jiang N, Ren R, Li C, Li C and Fu F: Sodium aescinate ameliorates liver injury induced by methyl parathion in rats. Exp Ther Med 3: 818-822, 2012.
APA
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., & Fu, F. (2012). Sodium aescinate ameliorates liver injury induced by methyl parathion in rats. Experimental and Therapeutic Medicine, 3, 818-822. https://doi.org/10.3892/etm.2012.479
MLA
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., Fu, F."Sodium aescinate ameliorates liver injury induced by methyl parathion in rats". Experimental and Therapeutic Medicine 3.5 (2012): 818-822.
Chicago
Du, Y., Wang, T., Jiang, N., Ren, R., Li, C., Li, C., Fu, F."Sodium aescinate ameliorates liver injury induced by methyl parathion in rats". Experimental and Therapeutic Medicine 3, no. 5 (2012): 818-822. https://doi.org/10.3892/etm.2012.479
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